Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression

Infection and Immunity

Volumn 64, Issue 3, 1996, Pages 913-918

  Gong, Jian Hua ^a   Zhang, Ming ^a   Modlin, Robert L ^b   Linsley, Peter S ^c   Iyer, Dinaker ^a   Lin, Yuanguang ^a   Barnes, Peter F ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; NEUTRALIZING ANTIBODY; RECOMBINANT INTERLEUKIN 12; THY 1 ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; DISEASE SEVERITY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS;

EID: 0030043392     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.3.913-918.1996     Document Type: Article

References (30)

1. Barnes, P. F., D. Chatterjee, J. S. Abrams, S. Lu, E. Wang, M. Yamamura, P. J. Brennan, and R. L. Modlin. 1992. Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J. Immunol. 149:541-547.
2. Barnes, P. F., S. D. Mistry, C. L. Cooper, C. Pirmez, T. H. Rea, and R. L. Modlin. 1989. Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculosis pleuritis. J. Immunol 142:1114-1119
3. Barnes, P. F., R. L. Modlin, and J. J. Ellner. 1994 T-cell responses and cytokines, p. 417-435. In B. R. Bloom (ed.). Tuberculosis: pathogenesis, protection, and control. American Society for Microbiology, Washington, D.C.
4. Bertagnolli, M. M., B. Lin, D. Young, and S. H. Herrmann. 1992. IL-12 augments antigen-dependent proliferation of activated T lymphocytes. J. Immunol. 149:3778-3783.
5. Bogdan, C., Y. Vodovotz, and C. Nathan. 1991. Macrophage deactivation by interleukin 10. J. Exp. Med. 174:1549-1555.
6. Carvalho, E. M., O. Bacellar, C. Brownell, T. Regis, R. L. Coffman, and S. Reed. 1994. Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis J. Immunol 152:5949-5956.
7. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/ IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041-1048.
8. de Waal Malefyt, R., J. Abrams, B. Bennett, C. Figdor, and J. E. De Vries. 1991. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp Med. 174:1209-1220.
9. de Waal Malefyt, R., J. Haanen, H. Spits, M. Roncarlo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. E. De Vries. 1991. Interleukin-10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915-924.
10. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol 147:3815-3822.
11. Flores Villanueva, P. O., H. Reiser, and M. J. Stadecker. 1994. Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of R7 and B7-2 costimulatory molecules by macrophages. J. Immunol. 153:5190-5199.
12. Ghalib, H. W., M. R. Piuvezam, Y. A. W. Skeiky, M. Siddig, F. A. Hashim, A. M. El-Hassan, D. M. Russo, and S. G. Reed. 1993. Interleukin-10 production correlates with pathology in human Leishmania donovani infections. J. Clin. Invest. 92:324-329.
13. Holaday, B. J., M. M. de Lima Pompeu, S. Jeronimo, M. J. Texeira, A. de Queiroz Sousa, A. W. Vasconcelos, R. D. Pearson, J. S. Abrams, and R. M. Locksley. 1993. Potential role for interleukin-10 in the immunosuppression associated with kala azar J. Clin. Invest. 92:2626-2632
14. Holland, S. M., E. M. Eisenstein, D. B. Kuhns, M. L. Turner, T. A. Fleisher, W. Strober, and J. I. Gallin. 1994. Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. N. Engl. J Med. 33:1348-1355.
15. Kaufmann, S. H. E. 1995 Immunity to intracellular microbial pathogens. Immunol. Today 16:338-342.
16. Leung, H. T., J. Bradshaw, J. S. Cleaveland, and P. S. Linsley, Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail J. Biol. Chem., in press.
17. Linsley, P. S., W. Brady, M. Urnes, L. S. Grosmaire, N. K. Damle, and J. A. Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174:561-569.
18. Linsley, P. S., J. L. Greene, P. Tan, J. Bradshaw, J. A. Ledbetter, C. Anasetti, and N. K. Damle. 1992 Coexpression of functional cooperation of CTLA-4 and CD28 in activated T lymphocytes. J. Exp. Med. 176:1595-1604
19. Nathan, C. F., G. Kaplan, W. R. Leris, A. Nusrat, M. D. Witmer, S. A. Sherwin, C. K. Job, C. R. Horowitz, R. M. Steinman, and Z. A. Cohn. 1986. Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N Engl. J. Med. 315:6-15.
20. Sampaio, E. P., A. L. Moreira, E. N. Sarno, A. M. Malta, and G. Kaplan. 1992 Prolonged treatment with recombinant interferon gamma induces erythema nodosum leprosum in lepromatous leprosy patients. J. Exp. Med. 175:1729-1737.
21. Sanchez, F. O., J. I. Rodriguez, G. Agudelo, and L. F. Garcia. 1994. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls Infect Immun. 62:5673-5678.
22. Sieling, P. A., J. S. Abrams, M. Yamamura, P. Salgame, B. R. Bloom, T. H. Rea, and R. L. Modlin. 1993. Immunosuppressive roles for interleukin-10 and interleukin-4 in human infection: in vitro modulation of T cell responses in leprosy. J. Immunol. 150:5501-5510.
23. Sieling, P. A., X. H. Wang, M. K. Gately, J. L. Oliveros, T. McHugh, P. F. Barnes, S. F. Wolf, L. Golkar, M. Yamamura, Y. Yogi, K. Uyemura, T. H. Rea, and R. L. Modlin. 1994. IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J. Immunol. 153:3639-3647.
24. Sundar, S., F. Rosenkaimer, M. L. Lesser, and H. W. Murray. 1995. Immunochemotherapy for a systemic intracellular infection: accelerated response using interferon-gamma in visceral leishmaniasis. J Infect. Dis. 171:992-996.
25. Toossi, Z., P. Gogate, H. Shiratsuchi, T. Young, and J. J. Ellner. 1995. Enhanced production of TGF-β by blood monocytes from patients with active tuberculosis and presence of TGF-β in tuberculous granulomatous lung lesions. J. Immunol. 154:465-473.
26. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277-279.
27. + T cells promptly produce interleukin 4 in response to in vivo challange with anti-CD3. J. Exp. Med. 179:1285-1295.
28. Zhang, M., M. K. Gately, E. Wang, S. F. Wolf, S. Lu, R. L. Moddin, and P. F. Barnes. 1994. Interleukin-12 at the site of disease in tuberculosis. J. Clin. Invest. 93:1733-1739.
29. Zhang, M., J. Gong, D. V. Iyer, B. E. Jones, R. L. Modlin, and P. F. Barnes. 1994. T cell cytokine responses in persons, with tuberculosis and human immunodeficiency virus infection. J. Clin. Invest. 94:2435-2442.
30. Zhang, M., Y. Lin, D. V. Iyer, J. Gong, J. S. Abrams, and P. F. Barnes. 1995. T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect. Immun. 63:3231-3234.