메뉴 건너뛰기




Volumn 3, Issue 3, 2003, Pages 227-232

The eosinophil as a therapeutic target in asthma: Beginning of the end, or end of the beginning?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; CHEMOKINE RECEPTOR CCR3; CORTICOSTEROID; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 5 ANTIBODY; MEPOLIZUMAB; SNARE PROTEIN;

EID: 0037502796     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(03)00040-7     Document Type: Review
Times cited : (32)

References (52)
  • 2
    • 0029782335 scopus 로고    scopus 로고
    • Pathology of mild, severe, and fatal asthma
    • Kay A.B. Pathology of mild, severe, and fatal asthma Am J Respir Crit Care Med 154 1996 S66-S69
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154
    • Kay, A.B.1
  • 3
    • 0030878829 scopus 로고    scopus 로고
    • Complexity and redundancy in the pathogenesis of asthma: Reassessing the roles of mast cells and T cells
    • Galli S.J. Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells J Exp Med 186 1997 343-347
    • (1997) J. Exp. Med. , vol.186 , pp. 343-347
    • Galli, S.J.1
  • 5
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness Annu Rev Immunol 17 1999 255-281
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 7
    • 0026068637 scopus 로고
    • Allergen-induced asthmatic responses. Relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors
    • Gibson P.G. Manning P.J. O'Byrne P.M. Girgis-Gabardo A. Dolovich J. Denburg J.A. Hargreave F.E. Allergen-induced asthmatic responses. Relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors Am Rev Respir Dis 143 1991 331-335
    • (1991) Am. Rev. Respir. Dis. , vol.143 , pp. 331-335
    • Gibson, P.G.1    Manning, P.J.2    O'Byrne, P.M.3    Girgis-Gabardo, A.4    Dolovich, J.5    Denburg, J.A.6    Hargreave, F.E.7
  • 8
    • 0032752344 scopus 로고    scopus 로고
    • Degranulation in eosinophils in human, but not in mouse, airways
    • Persson C.G. Erjefalt J.S. Degranulation in eosinophils in human, but not in mouse, airways Allergy 54 1999 1230-1232
    • (1999) Allergy , vol.54 , pp. 1230-1232
    • Persson, C.G.1    Erjefalt, J.S.2
  • 13
    • 0031135675 scopus 로고    scopus 로고
    • Asthma: Does IL-5 have a more provocative role?
    • Lee N.A. Lee J.J. Asthma: does IL-5 have a more provocative role? Am J Respir Cell Mol Biol 16 1997 497-500
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.16 , pp. 497-500
    • Lee, N.A.1    Lee, J.J.2
  • 17
    • 0037120054 scopus 로고    scopus 로고
    • Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion
    • Bandeira-Melo C. Woods L.J. Phoofolo M. Weller P.F. Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion J Exp Med 196 2002 841-850
    • (2002) J. Exp. Med. , vol.196 , pp. 841-850
    • Bandeira-Melo, C.1    Woods, L.J.2    Phoofolo, M.3    Weller, P.F.4
  • 19
    • 0031445441 scopus 로고    scopus 로고
    • Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells
    • Ying S. Robinson D.S. Meng Q. Rottman J. Kennedy R. Ringler D.J. Mackay C.R. Daugherty B.L. Springer M.S. Durham S.R. et al. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells Eur J Immunol 27 1997 3507-3516
    • (1997) Eur. J. Immunol. , vol.27 , pp. 3507-3516
    • Ying, S.1    Robinson, D.S.2    Meng, Q.3    Rottman, J.4    Kennedy, R.5    Ringler, D.J.6    Mackay, C.R.7    Daugherty, B.L.8    Springer, M.S.9    Durham, S.R.10
  • 20
    • 0031317530 scopus 로고    scopus 로고
    • Eokines: Synthesis, storage and release from human eosinophils
    • Lacy P. Moqbel R. Eokines: synthesis, storage and release from human eosinophils Mem Inst Oswaldo Cruz 92 Suppl 2 1997 125-133
    • (1997) Mem. Inst. Oswaldo Cruz , vol.92 , Issue.SUPPL. 2 , pp. 125-133
    • Lacy, P.1    Moqbel, R.2
  • 21
    • 0037108493 scopus 로고    scopus 로고
    • The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin
    • Phipps S. Ying S. Wangoo A. Ong Y.E. Levi-Schaffer F. Kay A.B. The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin J Immunol 169 2002 4604-4612
    • (2002) J. Immunol. , vol.169 , pp. 4604-4612
    • Phipps, S.1    Ying, S.2    Wangoo, A.3    Ong, Y.E.4    Levi-Schaffer, F.5    Kay, A.B.6
  • 22
    • 0036419905 scopus 로고    scopus 로고
    • What's in the pipeline? Prospects for monoclonal antibodies (mAbs) as therapies for lung diseases
    • Li L. Das A.M. Torphy T.J. Griswold D.E. What's in the pipeline? Prospects for monoclonal antibodies (mAbs) as therapies for lung diseases Pulm Pharmacol Ther 15 2002 409-416
    • (2002) Pulm. Pharmacol. Ther. , vol.15 , pp. 409-416
    • Li, L.1    Das, A.M.2    Torphy, T.J.3    Griswold, D.E.4
  • 25
    • 0034780052 scopus 로고    scopus 로고
    • The trials and tribulations of IL-5, eosinophils, and allergic asthma
    • O'Byrne P.M. Inman M.D. Parameswaran K. The trials and tribulations of IL-5, eosinophils, and allergic asthma J Allergy Clin Immunol 108 2001 503-508
    • (2001) J. Allergy Clin. Immunol. , vol.108 , pp. 503-508
    • O'Byrne, P.M.1    Inman, M.D.2    Parameswaran, K.3
  • 26
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page P.T. Menzies-Gow A.N. Kay A.B. Robinson D.S. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway Am J Respir Crit Care Med 167 2003 199-204
    • (2003) Am. J. Respir. Crit Care Med. , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 27
    • 0036884942 scopus 로고    scopus 로고
    • Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge
    • Liu L.Y. Sedgwick J.B. Bates M.E. Vrtis R.F. Gern J.E. Kita H. Jarjour N.N. Busse W.W. Kelly E.A. Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge J Immunol 169 2002 6452-6458
    • (2002) J. Immunol. , vol.169 , pp. 6452-6458
    • Liu, L.Y.1    Sedgwick, J.B.2    Bates, M.E.3    Vrtis, R.F.4    Gern, J.E.5    Kita, H.6    Jarjour, N.N.7    Busse, W.W.8    Kelly, E.A.9
  • 33
    • 0035185559 scopus 로고    scopus 로고
    • Multiple mechanisms of reflex bronchospasm in guinea-pigs
    • Canning B.J. Reynolds S.M. Mazzone S.B. Multiple mechanisms of reflex bronchospasm in guinea-pigs J Appl Physiol 91 2001 2642-2653
    • (2001) J. Appl. Physiol. , vol.91 , pp. 2642-2653
    • Canning, B.J.1    Reynolds, S.M.2    Mazzone, S.B.3
  • 34
    • 0033010930 scopus 로고    scopus 로고
    • Muscarinic blockade of methacholine induced airway and parenchymal lung responses in anaesthetised rats
    • Tulic M.K. Wale J.L. Petak F. Sly P.D. Muscarinic blockade of methacholine induced airway and parenchymal lung responses in anaesthetised rats Thorax 54 1999 531-537
    • (1999) Thorax , vol.54 , pp. 531-537
    • Tulic, M.K.1    Wale, J.L.2    Petak, F.3    Sly, P.D.4
  • 35
    • 0017229586 scopus 로고
    • Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection
    • Empey D.W. Laitinen L.A. Jacobs L. Gold W.M. Nadel J.A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection Am Rev Respir Dis 113 1976 131-139
    • (1976) Am. Rev. Respir. Dis. , vol.113 , pp. 131-139
    • Empey, D.W.1    Laitinen, L.A.2    Jacobs, L.3    Gold, W.M.4    Nadel, J.A.5
  • 36
    • 0024850599 scopus 로고
    • A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects
    • Minette P.A. Lammers J.W. Dixon C.M. McCusker M.T. Barnes P.J. A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects J Appl Physiol 67 1989 2461-2465
    • (1989) J. Appl. Physiol. , vol.67 , pp. 2461-2465
    • Minette, P.A.1    Lammers, J.W.2    Dixon, C.M.3    McCusker, M.T.4    Barnes, P.J.5
  • 37
    • 0021682569 scopus 로고
    • Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig
    • Fryer A.D. Maclagan J.Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig Br J Pharmacol 83 1984 973-978
    • (1984) Br. J. Pharmacol. , vol.83 , pp. 973-978
    • Fryer, A.D.1    Maclagan, J.2
  • 39
    • 0030671371 scopus 로고    scopus 로고
    • Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea-pigs
    • Evans C.M. Fryer A.D. Jacoby D.B. Gleich G.J. Costello R.W. Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea-pigs J Clin Invest 100 1997 2254-2262
    • (1997) J. Clin. Invest. , vol.100 , pp. 2254-2262
    • Evans, C.M.1    Fryer, A.D.2    Jacoby, D.B.3    Gleich, G.J.4    Costello, R.W.5
  • 40
    • 0033571468 scopus 로고    scopus 로고
    • Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection
    • Adamko D.J. Yost B.L. Gleich G.J. Fryer A.D. Jacoby D.B. Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection. Eosinophils mediate airway hyperresponsiveness, m(2) muscarinic receptor dysfunction, and antiviral effects J Exp Med 190 1999 1465-1478
    • (1999) J. Exp. Med. , vol.190 , pp. 1465-1478
    • Adamko, D.J.1    Yost, B.L.2    Gleich, G.J.3    Fryer, A.D.4    Jacoby, D.B.5
  • 43
    • 0025824513 scopus 로고
    • Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils
    • Moqbel R. Hamid Q. Ying S. Barkans J. Hartnell A. Tsicopoulos A. Wardlaw A.J. Kay A.B. Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils J Exp Med 174 1991 749-752
    • (1991) J. Exp. Med. , vol.174 , pp. 749-752
    • Moqbel, R.1    Hamid, Q.2    Ying, S.3    Barkans, J.4    Hartnell, A.5    Tsicopoulos, A.6    Wardlaw, A.J.7    Kay, A.B.8
  • 45
    • 0028933074 scopus 로고
    • Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils
    • Levi-Schaffer F. Lacy P. Severs N.J. Newman T.M. North J. Gomperts B. Kay A.B. Moqbel R. Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils Blood 85 1995 2579-2586
    • (1995) Blood , vol.85 , pp. 2579-2586
    • Levi-Schaffer, F.1    Lacy, P.2    Severs, N.J.3    Newman, T.M.4    North, J.5    Gomperts, B.6    Kay, A.B.7    Moqbel, R.8
  • 47
    • 0032773835 scopus 로고    scopus 로고
    • Exocytotic events in eosinophils and mast cells
    • Moqbel R. Lacy P. Exocytotic events in eosinophils and mast cells Clin Exp Allergy 29 1999 1017-1022
    • (1999) Clin. Exp. Allergy. , vol.29 , pp. 1017-1022
    • Moqbel, R.1    Lacy, P.2
  • 48
    • 0033168291 scopus 로고    scopus 로고
    • Rapid mobilization of intracellularly stored RANTES in response to interferon-gamma in human eosinophils
    • Lacy P. Mahmudi-Azer S. Bablitz B. Hagen S.C. Velazquez J.R. Man S.F. Moqbel R. Rapid mobilization of intracellularly stored RANTES in response to interferon-gamma in human eosinophils Blood 94 1999 23-32
    • (1999) Blood , vol.94 , pp. 23-32
    • Lacy, P.1    Mahmudi-Azer, S.2    Bablitz, B.3    Hagen, S.C.4    Velazquez, J.R.5    Man, S.F.6    Moqbel, R.7
  • 49
    • 0035038737 scopus 로고    scopus 로고
    • Fusion protein vesicle-associated membrane protein 2 is implicated in IFN-gamma-induced piecemeal degranulation in human eosinophils from atopic individuals
    • Lacy P. Logan M.R. Bablitz B. Moqbel R. Fusion protein vesicle-associated membrane protein 2 is implicated in IFN-gamma-induced piecemeal degranulation in human eosinophils from atopic individuals J Allergy Clin Immunol 107 2001 671-678
    • (2001) J. Allergy Clin. Immunol. , vol.107 , pp. 671-678
    • Lacy, P.1    Logan, M.R.2    Bablitz, B.3    Moqbel, R.4
  • 50
    • 0036170805 scopus 로고    scopus 로고
    • Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis
    • Logan M.R. Lacy P. Bablitz B. Moqbel R. Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis J Allergy Clin Immunol 109 2002 299-306
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 299-306
    • Logan, M.R.1    Lacy, P.2    Bablitz, B.3    Moqbel, R.4
  • 51
    • 0036625065 scopus 로고    scopus 로고
    • Translocation of the tetraspanin CD63 in association with human eosinophil mediator release
    • Mahmudi-Azer S. Downey G.P. Moqbel R. Translocation of the tetraspanin CD63 in association with human eosinophil mediator release Blood 99 2002 4039-4047
    • (2002) Blood , vol.99 , pp. 4039-4047
    • Mahmudi-Azer, S.1    Downey, G.P.2    Moqbel, R.3
  • 52
    • 0027376537 scopus 로고
    • Efficacy and safety of inhaled corticosteroids in asthma. Report of a workshop held in Eze, France, October 1992
    • Barnes P.J. Pedersen S. Efficacy and safety of inhaled corticosteroids in asthma. Report of a workshop held in Eze, France, October 1992 Am Rev Respir Dis 148 1993 S1-S26
    • (1993) Am. Rev. Respir. Dis. , vol.148
    • Barnes, P.J.1    Pedersen, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.