Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

EMBO Journal

Volumn 21, Issue 24, 2002, Pages 6721-6732

  Shen, Yuequan ^a   Lee, Young Sam ^a   Soelaiman, Sandriyana ^a   Bergson, Pamela ^a   Lu, Dan ^a   Chen, Alice ^a   Beckingham, Kathy ^b   Grabarek, Zenon ^c   Mrksich, Milan ^a   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b RICE UNIVERSITY   (United States)

^c BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Adenylyl cyclase exotoxin; Anthrax edema factor; Ca2+ calmodulin; CyaA; Enzyme activation

Indexed keywords

ADENYLATE CYCLASE; BACTERIAL TOXIN; CALCIUM; CALMODULIN; EXOTOXIN;

ANTHRAX; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; INHIBITION KINETICS; PERTUSSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; REGULATORY MECHANISM; SURFACE PLASMON RESONANCE; TOXIN ANALYSIS;

NON-PROGRAMMATIC;

ADENYLATE CYCLASE; BINDING SITES; CALCIUM; CALMODULIN; CATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ESCHERICHIA COLI; EXOTOXINS; MAGNESIUM; MODELS, MOLECULAR; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; VIPER VENOMS;

ANTHRAX; BACTERIA (MICROORGANISMS);

EID: 12244306922     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf681     Document Type: Article

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