Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models

Epilepsy Research

Volumn 50, Issue 1-2, 2002, Pages 141-160

  Pitkänen, Asla ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Anticonvulsant; Antiepileptogenic; Epileptogenesis; Plasticity; Seizure

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; DIAZEPAM; ENFLURANE; ETHOSUXIMIDE; ETIRACETAM; ETOMIDATE; FELBAMATE; GABAPENTIN; HALOTHANE; ISOFLURANE; LAMOTRIGINE; LORAZEPAM; MIDAZOLAM; OXCARBAZEPINE; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; PROPOFOL; THIOPENTAL; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CONFERENCE PAPER; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; EPILEPSY; EPILEPTOGENESIS; HUMAN; KINDLING; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTICONVULSANTS; DISEASE PROGRESSION; EPILEPSY; HUMANS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS;

EID: 0036345477     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(02)00076-1     Document Type: Conference Paper

References (123)

1. Anticonvulsant and neonatal protective effects of propofol on experimental status epilepticus
2. Development of a new pharmacological seizure model: Effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat
3. Antiepileptic effects of topiramate on amygdaloid kindling in rats
4. Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy
5. Effect of 2.6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil
6. Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome
7. The role of epileptic activity in hippocampal and 'remote' cerebral lesions induced by kainic acid
8. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
9. Neuroprotective effects of felbamate on global ischemia in Mongolian gerbils
10. Comparison of valproate and phenobarbital treatment after status epilepticus in rats
11. Tiagabine treatment and DNA damage in rat astrocytes: An in vitro study by comet assay
12. Valproate robustly enhances AP-1 mediated gene expression
13. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
14. Anticonvulsant action and long-term effects of gabapentin in the immature brain
15. Thiopentone and methohexital, but not pentobarbitone, red early focal cerebral ischemic injury in rats
16. Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest
17. Tiagabine exerts an anti-epileptogenic effect in amygdala kindling epileptogenesis in the rat
18. Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin
19. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia
20. A DNA microarray analysis of epileptogenesis in the mouse dentate gyrus
21. The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats
22. Delayed sclerosis, neuroprotection and limbic epileptogenesis after status epilepticus in the rat
23. Dna microarray analysis indicates that extracellular matrix components sparc and SC1 are differentially regulated in the rat dentate gyrus after status epilepticus
24. Mesial temporal lobe epilepsy
25. Only certain anticonvulsants protect against kainate neurotoxicity
26. Anticonvulsant effects of the novel antiepileptic drug levetiracetam in the rat pilocarpine model of temporal lobe epilepsy
27. A permanent change in brain function resulting from daily electrical stimulation
28. Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampus
29. Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus
30. Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat
31. Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat
32. Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats
33. Insidence and prevalence
34. Relationship between the dose-response effects of diazepam and clobazam on electroencephalographic parameters and on kindled amygdaloid seizure activity in rats
35. Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats
36. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: Assessment of a rat model of temporal lobe epilepsy
37. Preventing post-traumatic epilepsy after brain injury: Weighting costs and benefits of anticonvulsant prophylaxis
38. Risk of unprovoked seizure after acute symptomatic seizure: Effect of status epilepticus
39. Effects of clobazam on amygdaloid and hippocampal kindled seizures in rats
40. Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus
41. Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells
42. Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system
43. Neurobiology of epileptogenesis in the temporal lobe
44. Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia
45. Hippocampal kindling protects several structures from the neuronal damage resulting from kainic acid-induced status epilepticus
46. A reversible type of neuronal injury following ishemia in the gerbil hippocampus
47. Effects of prolonged administration of levetiracetam on pilocarpine-induced epileptogenesis
48. Topiramate blocks perinatal hypoxia-induced seizures in rat pups
49. The effects of propofol on brain electrical activity, neurolog... outcome, and neuronal damage following incomplete ischemia in rats
50. Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: Cross-tolerance to carbamazepine but not valporate or diazepam
51. Failure of carbamazepine to prevent behavioural and histopathological sequels of experimentally induced status epilepticus
52. Protective effect of etomidate on kainic acid-induced neurotoxicity in rat hippocampus
53. Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbils
54. Distribution of early neuronal damage after status epilepticus in chronic model of TLE induced by amygdala stimulation
55. Valproic acid
56. Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats
57. Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model
58. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
59. PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat
60. Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures
61. National general practice study of epilepsy (NGPSE): Partial seizure patterns in a general population
62. Protective effects of clonazepam on ischemic brain damage induced by 10 minute bilateral carotid occlusion in Mongolian gerbils
63. Felbamate in experimental model of status epilepticus
64. Analysis of the molecular basis of kindling development
65. Phenobarbital modifies seizure-related brain injury in the developing brain
66. Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats
67. +
68. BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy
69. Anticonvulsant effect of topiramate on amygdaloid kindled seizures in cats
70. Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat
71. Topiramate reduces neuronal injury after experimental status epilepticus
72. An animal model with spontaneous seizures: A new tool for testing the effects of antiepileptic compounds
73. A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat
74. Diazepam treatment has a disease-modifying effect on the developing epilepsy after status epilepticus in rat
75. The effect of lamotrigine upon development of cortical kindled seizures in the rat
76. Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in rats
77. Zonisamide as a neuroprotective agent in an adult gerbil mo... of global forebrain ischemia: A histological, in vivo microdialysis and behavioral study
78. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus
79. Prevention of Epileptogenesis
80. Epileptogenesis related changes in gene expression in the rat model of temporal lobe epilepsy
81. Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdala
82. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus
83. Lamotrigine treatment during amygdala-kindled seizure development fails to inhibit seizures and diminishes subsequent anticonvulsant efficacy
84. Comparative study of voltage-sensitive sodium channel blockers in focal ischemia and electric convulsions in rodents
85. Anticonvulsant effect of tiagabine, a new antiepileptic drug: The profile of action in the rat kindling model of epilepsy
86. Inhibition or enhancement kindling evolution by antiepileptics
87. Oxcarbazepine: Preclinical anticonvulsant profile and putative mechanisms of action
88. Postischemic diazepam is neuroprotective in the gerbil hippocampus
89. Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum
90. Anti-seizure and anti-epileptogenic effect of γ-vinyl γ-aminobutyric acid in amygdaloid kindling
91. Does convulsive status epilepticus (SE) result in cerebral damage or affect the course of epilepsy-the epidemiological and clinical evidence?
92. Anticonvulsant drugs selectively affect kindled and penicillin epilepsy, especially during seizure-prone sleep of awakening states in cats
93. Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study
94. Neuroprotection with felbamate: A 7 and 28 days study in transient forebrain ischemia in gerbils
95. The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: A morphological study with early and delayed evaluations
96. Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy
97. Cerebroprotective effect of lamotrigine after focal ischemia in rats
98. Felbamate-mechanism of action
99. Antiepileptogenic-like effects of lamotrigine in a rat amygdala kindling model
100. Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital
101. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: Meta-analysis of controlled trials
102. 2+ decrease assessed in the hippocampus by brain dialysis
103. Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration on afterdischarges
104. Postischemic seizures and necrotizing ischemic brain damage: Neuroprotective effects of postischemic diazepam and insulin
105. Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex
106. Halothane as a neuroprotectant during constants stimulation of the perforant path
107. Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Possible influence on thermoregulation
108. Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia
109. Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia
110. Felbamate protects CA1 neurons from apoptosis in a gerbil model of global ischemia
111. Topiramate: A potent anticonvulsant in the amygdala-kindled rat
112. Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development
113. A neuropharmacological evaluation of felbamate as a novel anticonvulsant
114. Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia
115. Neuroprotective activity of tiagabine in a focal embolic model of cerebral ischemia
116. Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization
117. Dose-dependent neuroprotection with tiagabine in a focal cerebral ischemia model in rat
118. Usefulness of postischemic thrombolysis with of without neuroprotection in a focal embolic model of cerebral ischemia
119. Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy
120. Vigabatrin pre-treatment prevents hilar somatostatin cell loss and the development of interictal spiking activity following sustained stimulation of the perforant path
121. Propofol neuroprotection in a rat model of ischemia reperfusion injury