Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat

Experimental Neurology

Volumn 167, Issue 2, 2001, Pages 227-241

  Dubé, Céline ^a   Boyet, Sylvette ^a   Marescaux, Christian ^a   Nehlig, Astrid ^a  

^a INSERM   (France)

Author keywords

Cerebral glucose metabolism; Chronic period; Epilepsy; Lithium pilocarpine; Neuronal damage; Postnatal development; Seizures; 14C 2 deoxyglucose

Indexed keywords

DEOXYGLUCOSE; LITHIUM; PILOCARPINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CELL LOSS; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; FEMALE; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035125554     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7561     Document Type: Article

References (61)

1. Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy
2. The lesional and epileptic consequences of lithium-pilocarpine-induced status epilepticus are affected by previous exposure to isolated seizures: Effects of amygdala kindling and maximal electroshocks
3. Topography of interictal glucose metabolism in unilateral mesiotemporal epilepsy
4. Dendritic morphology in epileptogenic cortex from TRPE patients, revealed by intracellular Lucifer Yellow microinjection and confocal laser scanning microscopy
5. Functional anatomy of limbic epilepsy: A proposal for central synchronization of a diffusely hyperexcitable network
6. Interictal spikes increase cerebral glucose metabolism and blood flow: A PET study
7. The pilocarpine model of epilepsy
8. The susceptibility of rats to pilocarpine-induced seizures is age-dependent
9. Interictal and postical hypermetabolism on positron-emission tomography
10. The functional anatomy and pathology of lithum-pilocarpine and high doses pilocarpine seizures
11. The thalamic GABAergic system in experimental chronic epilepsy in the rat
12. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
13. Hippocampal cell density and subcortical metabolism in temporal lobe epilepsy
14. Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat
15. Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes
16. Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy
17. The use of positron emission tomographic scanning in epilepsy
18. Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats
19. Correlation between hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy
20. Increase in the number of axospinous synapses with segmented postsynaptic densities following hippocampal kindling
21. 14C]glucose uptake and c-fos-like reactivity
22. 14C-deoxyglucose study in the lithium-pilocarpine model in rat
23. 14C-deoxyglucose study
24. Seizure recency and frequency effects of the probability of finding focal hypometabolism on interictal fluorodeoxyglucose PET scans in complex partial epilepsy
25. Quantifying interictal metabolic activity in human temporal lobe epilepsy
26. Interictal metabolic anatomy of mesial temporal lobe epilepsy
27. Hippocampal neuronal loss and regional metabolism in temporal lobe epilepsy
28. Progress in epilepsy research functional neuroimaging with positron emission tomography
29. Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats
30. Effects of kainic acid on seizure susceptibility in the developing brain
31. Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices
32. NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats
33. Decreased time constant in hippocampal dentate granule cells in pilocarpine-treated rats with progressive seizure frequencies
34. Thalamic glucose metabolism in temporal lobe epilepsy measured with 18-FDG positron emission tomography (PET)
35. Progressive accumulation of large aggregates of calcium-containing polysaccharides and basophilic debris within specific thalamic nuclei after lithium/pilocarpine-induced-seizures
36. The dynamics of metabolic change following seizures as measured by positron emission tomography with fluorodeoxyglucose F18
37. Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats
38. Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons
39. Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy
40. Epileptic brain damage in rats induced by sustained electrical stimulation of the perforant path II. Ultrastructural analysis of acute hippocampus pathology
41. 3H]2-deoxy-D-glucose
42. Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine
43. Changes to synaptic ultrastructure in field CA1 of the rat hippocampus following intracerebroventricular injection of kainic acid
44. Developmental aspects of the pilocarpine model of epilepsy
45. Denervation-induced dendritic alterations in CA1 pyramidal cells following kainic and hippocampal lesions in rats
46. Modification of seizure activity by electrical stimulation. II. Motor seizure
47. Cerebral metabolic topography in unilateral temporal lobe epilepsy
48. Metabolic patterns associated with non specific magnetic resonance imaging abnormalities in temporal lobe epilepsy
49. Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin
50. Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
51. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat
52. Subcortical metabolic alteration in partial epilepsy
53. Temporal lobectomy for refractory epilepsy
54. Kainic acid seizures in the developing brain: Status epilepticus and spontaneous recurrent seizures
55. 18F]-Fluorodeoxyglucose positron emission tomography in refractory complex partial seizures
56. The role of positron emission tomography in the evaluation of seizures disorders
57. Patterns of cerebral glucose metabolism in patients with partial seizures
58. Pathology of temporal lobe foci: Correlation with CT, MRI and PET
59. Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
60. Spontaneous paroxysmal electroclinical patterns in rat: A model of generalized nonconvulsive epilepsy