Epithelial to mesenchymal transition in madin-darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-β-induced growth arrest

Journal of Biological Chemistry

Volumn 278, Issue 5, 2003, Pages 3251-3256

  Nicolás, Francisco J ^a   Lehmann, Kerstin ^a,b   Warne, Patricia H ^a   Hill, Caroline S ^a   Downward, Julian ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b metagen GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL ACTIVATION; COMPLEXATION;

EPITHELIAL CELLS;

BIOCHEMISTRY;

MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RECEPTOR; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; DNA BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL TRANSFORMATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; KIDNEY CELL; KIDNEY EPITHELIUM; KIDNEY INTERSTITIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CYTOLOGY; DOG; DRUG EFFECT; GENETICS; KIDNEY; MESODERM; PHYSIOLOGY; UROTHELIUM;

ANIMALIA;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; DOGS; GENE EXPRESSION REGULATION; KIDNEY; MAP KINASE SIGNALING SYSTEM; MESODERM; PHENOTYPE; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; UROTHELIUM;

EID: 0037474330     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209019200     Document Type: Article

References (25)

1. Akhurst, R. J., and Derynck, R. (2001) Trends Cell Biol. 11, S44-S51
2. Derynck, R., Ackhurst, R. J., and Balmain, A. (2001) Nat. Genet. 29, 117-129
3. Wakefield, L. M., and Roberts, A. B. (2002) Curr. Opin. Genet. Dev. 12, 22-29
4. Lehmann, K., Janda, E., Pierreux, C. E., Rytömaa, M., Schulze, A., McMahon, M., Hill, C. S., Beug, H., and Downward, J. (2000) Genes Dev. 14, 2610-2622
5. Hay, E. D. (1995) Acta Anat. 154, 8-20
6. Massagué, J., and Wotton, D. (2000) EMBO J. 19, 1745-1754
7. Woods, D., Parry, D., Cherwinski, H., Bosch, E., Lees, E., and McMahon, M. (1997) Mol. Cell. Biol. 17, 5598-5611
8. Morgenstern, J. P., and Land, H. (1990) Nucleic Acids Res. 18, 3587-3596
9. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
10. Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., and Hill, C. S. (2002) Mol. Pharmacol. 62, 65-72
11. Wong, C., Rougier-Chapman, E. M., Frederick, J. P., Datto, M. B., Liberati, N. T., Li, J. M., and Wang, X. F. (1999) Mol. Cell. Biol. 19, 1821-1830
12. Khwaja, A., Hallberg, B., Warne, P. H., and Downward, J. (1996) Oncogene 12, 2491-2498
13. Pierreux, C. E., Nicolás, F. J., and Hill, C. S. (2000) Mol. Cell. Biol. 20, 9041-9054
14. Howell, M., and Hill, C. S. (1997) EMBO J. 16, 7411-7421
15. Yoshiura, K., Kanai, Y., Ochiai, A., Shimoyama, Y., Sugimura, T., and Hirai, K. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7416-7419
16. Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., and Reichmann, E. (1996) Genes Dev. 10, 2462-2477
17. Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M., and Massagué, J. (1990) Cell 62, 175-185
18. Massagué, J., Blain, S. W., and Lo, R. S. (2000) Cell 103, 295-309
19. Datto, M. B., Yu, Y., and Wang, X.-F. (1995) J. Biol. Chem. 270, 28623-28628
20. Geng, Y., and Weinberg, R. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 10315-10319
21. Ashcroft, G. S., Yang, X., Glick, A. B., Weinstein, M., Letterio, J. L., Mizel, D. E., Anzano, M., Greenwell-Wild, T., Wahl, S. M., Deng, C., and Roberts, A. B. (1999) Nat. Cell Biol. 1, 260-266
22. Piek, E., Ju, W. J., Heyer, J., Escalanate-Alcalde, D., Stewart, C. L., Weinstein, M., Deng, C., Kucherlapati, R., Böttinger, E. P., and Roberts, A. B. (2001) J. Biol. Chem. 276, 19945-19953
23. Datto, M. B., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., and Wang, X. F. (1999) Mol. Cell. Biol. 19, 2495-2504
24. Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Nature 417, 949-954
25. Woodford-Richens, K. L., Rowan, A. J., Gorman, P., Halford, S., Bicknell, D. C., Wasan, H. S., Roylance, R. R., Bodmer, W. F., and Tomlinson, I. P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9719-9723