Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: Correlation with asymmetric dimethylarginine levels

Circulation

Volumn 107, Issue 3, 2003, Pages 429-436

  Piatti, PierMarco ^a,e   Fragasso, Gabriele ^c   Monti, Lucilla D ^a   Setola, Emanuela ^a   Lucotti, Pietro ^a   Fermo, Isabella ^d   Paroni, Rita ^d   Galluccio, Elena ^a   Pozza, Guido ^b   Chierchia, Sergio ^c   Margonato, Alberto ^c  

^a Divisione di Medicina Generale   (Italy)

^b Cattedra Clin Medica Generale   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d Laboratorio di Tecniche Separative   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Amino acids; Angina; Arteries; Endothelin; Nitric oxide

Indexed keywords

ARGININE; CYCLIC GMP; ENDOTHELIN 1; ERGOMETRINE; GLUCOSE; INSULIN; N(G),N(G) DIMETHYLARGININE; NITRATE; NITRITE; SODIUM CHLORIDE;

ADULT; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD VESSEL REACTIVITY; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG INFUSION; ENDOTHELIUM CELL; ENZYME INHIBITION; FEMALE; FOREARM BLOOD FLOW; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNDROME X; TREATMENT OUTCOME;

ANGINA PECTORIS; ARGININE; BLOOD PRESSURE; CORONARY ANGIOGRAPHY; CYCLIC GMP; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; MALE; MIDDLE AGED; NITRIC OXIDE; REGIONAL BLOOD FLOW; SYNDROME;

EID: 0037469213     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000046489.24563.79     Document Type: Article

References (48)

1. Vanhoutte PM. The endothelium: modulator of vascular smooth muscle tone. N Engl J Med. 1988;319:512-513.
2. Baron AD. The coupling of glucose metabolism and perfusion in human skeletal muscle: the potential role of endothelium-derived nitric oxide. Diabetes. 1996;45:S105-S109.
3. Steinberg HO, Brechtel G, Johnson A, et al. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94:1172-1179.
4. Piatti PM, Fragasso G, Monti LD, et al. Endothelial and metabolic characteristics of patients with angina and angiographically normal arteries: comparison with subjects with insulin resistance syndrome and normal controls. J Am Coll Cardiol. 1999;34:1452-1460.
5. Egashira K, Inou T, Hirooka Y, et al. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. N Engl J Med. 1993;328:1659-1664.
6. Egashira K, Hirooka Y, Takeshi K, et al. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation. 1996;94:130-134.
7. Bottcher M, Botker HE, Sonne H, et al. Endothelium-dependent and -independent perfusion reserve and effect of L-arginine on myocardial perfusion in patients with syndrome X. Circulation. 1999;99:1795-1801.
8. Vallance P, Leone A, Calver A, et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 1992;339:572-575.
9. Boger RH, Bode-Boger SM, Szuba A, et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98:1842-1847.
10. Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol. 2000;20:2032-2037.
11. Chan JR, Boger RH, Bode-Boger SM, et al. Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Arterioscler Thromb Vasc Biol. 2000;20:1183-1197.
12. Jun T, Wennmalm A. NO-dependent and -independent elevation of plasma levels of insulin and glucose in rats by L-arginine. Br J Pharmacol. 1994;113:345-348.
13. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest. 1996;97:1989-1994.
14. Theilmeier G, Chan JR, Zalpour C, et al. Adhesiveness of mononuclear cells in hypercholesterolemic humans in normalized by dietary L-arginine. Arterioscler Thromb Vasc Biol. 1997;17:3557-3564.
15. Tsao PS, Theilmeier G, Singer AH, et al. L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler Thromb. 1994;14:1529-1533.
16. Tsao PS, McEvoy LM, Drexler H, et al. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation. 1994;89:2176-2182.
17. Cooke PJ, Singer AH, Tsao PS, et al. Anti-atherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest. 1992;90:1168-1172.
18. Piatti PM, Monti LD, Conti M, et al. Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans. Diabetes. 1996;45:316-321.
19. Van Haeften TW, Voetberg GA, Gerich JE, et al. Dose-response characteristics for arginine-stimulated insulin release in man and influence of hyperglycemia. J Clin Endocrinol Metab. 1989;69:1059-1064.
20. Piatti PM, Monti LD, Davis SN, et al. Effects of an acute decrease in nonesterified fatty acid levels on muscle glucose utilization and forearm indirect calorimetry in lean NIDDM patients. Diabetologia. 1996;39:103-112.
21. Capaldo B, Guardasole V, Pardo F, et al. Abnormal vascular reactivity in growth hormone deficiency. Circulation. 2001;103:520-524.
22. Verdon CP, Burto BA, Prior RL. Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite. Anal Biochem. 1995;224:502-508.
23. Pettersson A, Uggla L, Backman V. Determination of dimethylated arginines in human plasma by high performance liquid chromatography. J Chromatogr B. 1997;692:257-262.
24. Pi J, Kumagai Y, Sun G, et al. Improved method for simultaneous determination of L-arginine and its mono- and dimethylated metabolites in biological samples by high performance liquid chromatography. J Chromatogr B. 2000:742:199-203.
25. Vallance P. Importance of asymmetrical dimethylarginine in cardiovascular risk. Lancet. 2001;358:2096-2097.
26. Stuhlinger MC, Abbasi F, Chu JW, et al. Relationship between insulin resistance and endogenous nitric oxide synthase inhibitor. JAMA. 2002;287:1420-1426.
27. Beppu M, Obayashi S, Aso T, et al. Endogenous nitric oxide inhibitors in endothelial cell, endothelin-1 within the vessel wall, and intimal hyperplasia in perimenopausal human uterine arteries. J Cardiovasc Pharmacol. 2002;39:192-200.
28. Buffon A, Rigattieri S, Santini SA, et al. Myocardial ischemiareperfusion damage after pacing induced tachycardia in patients with cardiac syndrome X. Am J Physiol Heart Circ Physiol. 2000;279: H2627-H2633.
29. Giuliano D, Marfella R, Verrazzo G, et al. The vascular effects of L-arginine in humans. J Clin Invest. 1997;99:433-438.
30. Lerman A, Burnett JC, Higano ST, et al. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 1998;97:2123-2128.
31. Kaski JC, Elliott PM, Salomone O, et al. Concentration of circulating plasma endothelin in patients with angina and normal coronary angiograms. Br Heart J. 1995;74:620-624.
32. Cox ID, Botker HE, Bagger JP, et al. Elevated endothelin concentrations are associated with reduced coronary vasomotor responses in patients with chest pain and normal coronary arteriograms. J Am Cardiol. 1999;34:455-460.
33. Lerman A, Holmes DR Jr, Bell MR, et al. Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans. Circulation. 1995;92:2426-2431.
34. Ikeda U, Yamamoto K, Maeda Y, et al. Endothelin-1 inhibits nitric oxide synthesis in vascular smooth muscle cells. Hypertension. 1997;29:65-69.
35. Luscher TF, Yang Z, Tschudi M, et al. Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins. Circ Res. 1990;66:1088-1094.
36. Di Luozzo G, Bhargava J, Powell RJ. Vascular smooth cell effect on endothelial cell endothelin-1 production. J Vasc Surg. 2000;31:781-789.
37. Verhaar MC, Strachan FE, Newby DE, et al. Endothelin-A receptor antagonist-mediated vasodilation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation. 1998;97:752-756.
38. Hirata Y, Yoshimi H, Takaichi S, et al. Binding and receptor down-regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. FEBS Lett. 1988;239:13-17.
39. Newby DE, Flint LL, Fox KAA, et al. Reduced responsiveness to endothelin-I in peripheral resistance vessels of patients with syndrome X. J Am Coll Cardiol. 1998;31:1585-1590.
40. Saito Y, Nakao K, Mukoyama M, et al. Increased plasma endothelin-1 in patients with essential hypertension. N Engl J Med. 1990;322:205. Letter.
41. Piatti PM, Monti LD, Galli L, et al. Relationship between endothelin-1 concentration and metabolic alterations typical of the insulin resistance syndrome. Metabolism. 2000;49:748-752.
42. Miyauchi T, Yanagishawa M, Tomizawa T, et al. Increased plasma concentration of endothelin-1 and big endothelin-1 in acute myocardial infarction. Lancet. 1989;2:53-54.
43. Lerman A, Edwards BS, Hallett JW, et al. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med. 1991;325:997-1001.
44. Drexler H, Zeiher AM, Meinzer K, et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet. 1991;338:1546-1550.
45. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 1997:80:331-333.
46. Blum A, Hathaway L, Mincemoyer R, et al. Oral L-arginine in patients with coronary artery disease on medical management. Circulation. 2000;101:2160-2170.
47. Pritchard KA, Groszek L, Smalley DM, et al. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res. 1995;77:510-518.
48. Kamada Y, Nagaretani H, Tamura S, et al. Vascular endothelial dysfunction resulting from L-arginine deficiency in patients with lysinuric protein intolerance. J Clin Invest. 2001;108:717-724.