Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor

JAMA

Volumn 287, Issue 11, 2002, Pages 1420-1426

  Stühlinger, Markus C ^a,b   Abbasi, Fahim ^a   Chu, James W ^a   Lamendola, Cindy ^a   McLaughlin, Tracey L ^a   Cooke, John P ^a   Reaven, Gerald M ^a   Tsao, Philip S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; ROSIGLITAZONE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLISM; OUTCOMES RESEARCH; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0037139438     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.287.11.1420     Document Type: Article

References (44)

1. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
2. Banting lecture 1988: Role of insulin resistance in human disease
3. Hyperinsulinemia in a normal population as a predictor of noninsulin-dependent diabetes mellitus, hypertension, and coronary heart disease: The Barilla factory revisited
4. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease
5. Endothelial dysfunction in the coronary microcirculation: A new clinical entity or an experimental finding?
6. Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the syndrome of insulin resistance
7. Relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension
8. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance
9. Comparison of plasminogen activator inhibitor-1 concentration in insulin-resistant versus insulin-sensitive healthy women
10. Circulating endothelin-1 levels in obese patients with the metabolic syndrome
11. Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers
12. Mononuclear cell adherence to cultured endothelium is enhanced by hypertension and insulin resistance in healthy nondiabetic volunteers
13. Atherosclerosis: An inflammatory disease
14. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
15. Endogenous nitric oxide synthase inhibitor: A novel marker of atherosclerosis
16. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia
17. Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans
18. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
19. Adherence of mononuclear cells to endothelium in vitro is increased in patients with NIDDM
20. Resistance to insulin-stimulate-dglucose uptake in patients with hypertension
21. Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp
22. Determination of dimethylated arginines in human plasma by high-performance liquid chromatography
23. Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers
24. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus
25. Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension
26. Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: Relationship to treatment method and atherosclerotic disease
27. Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia
28. Insulin resistance of uremia
29. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study
30. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
31. Importance of asymmetrical dimethylarginine in cardiovascular risk
32. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases
33. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase
34. Homocysteine impairs the nitric oxide synthase pathway: Role of asymmetric dimethylarginine
35. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis
36. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease
37. Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans
38. Effects of some guanidino compounds on human cerebral arteries
39. Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
40. Endothelial nitric oxide production and insulin sensitivity: A physiological link with implications for pathogenesis of cardiovascular disease
41. Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes
42. Increased reduction of dimethylarginines and lowered interdialytic blood pressure by the use of biocompatible membranes
43. Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in renal failure patients
44. Concentration of dimethyl-L-arginine in the plasma of patients with endstage renal failure