-
2
-
-
0034699492
-
BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3482-3486
-
-
Babu, Y.S.1
Chand, P.2
Bantia, S.3
Kotian, P.4
Dehghani, A.5
El-Kattan, Y.6
Lin, T.-H.7
Hutchison, T.L.8
Elliott, A.J.9
Parker, C.D.10
Ananth, S.L.11
Horn, L.L.12
Laver, G.W.13
Montgomery, J.A.14
-
3
-
-
0035080983
-
Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 1162-1167
-
-
Bantia, S.1
Parker, C.D.2
Ananth, S.L.3
Horn, L.L.4
Andries, K.5
Chand, P.6
Kotian, P.L.7
Dehghani, A.8
El-Kattan, Y.9
Lin, T.10
Hutchison, T.L.11
Montgomery, J.A.12
Kellog, D.L.13
Babu, Y.S.14
-
4
-
-
0015861774
-
Relationship between the inhibition constant, Ki, and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
-
(1973)
Biochem. Pharmacol.
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.-C.1
Prusoff, W.H.2
-
6
-
-
0027154004
-
Post-antibiotic effects in experimental infection models: Relationship to in-vitro phenomena and to treatment of infections in man
-
(1993)
J. Antimicrob. Chemother.
, vol.31
, Issue.SUPPL. D
, pp. 149-158
-
-
Craig, W.A.1
-
9
-
-
0029550466
-
2,3-Didehydro-2,4-dideoxy-4-goanidino-N-acetyl-D-neuraminic acid is a slow-binding inhibitor of sialidase from both influenza A virus and influenza B virus
-
(1995)
Mol. Biol. Int.
, vol.36
, pp. 695-703
-
-
Hart, G.J.1
Bethell, R.C.2
-
13
-
-
9844220300
-
Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections
-
(1997)
New Engl. J. Med.
, vol.337
, pp. 874-880
-
-
Hayden, F.G.1
Osterhaus, A.D.M.E.2
Treanor, J.3
Fleming, D.M.4
Aoki, G.Y.5
Nicholson, K.G.6
Bohnen, A.M.7
Hirst, H.M.8
Keene, O.9
Wightman, K.10
-
14
-
-
0033530264
-
Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza
-
(1999)
JAMA
, vol.282
, pp. 1240-1246
-
-
Hayden, F.G.1
Treanor, J.J.2
Fritz, R.S.3
Lobo, M.4
Betts, R.F.5
Miller, M.6
Kinnersley, N.7
Mills, R.G.8
Ward, P.9
Straus, S.E.10
-
16
-
-
0034878865
-
Novel α- and β-amino acid inhibitors of influenza virus neuraminidase
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 2563-2570
-
-
Kati, W.M.1
Montgomery, D.2
Maring, C.3
Stoll, V.S.4
Giranda, V.5
Chen, X.6
Laver, W.G.7
Kohlbrenner, W.8
Norbeck, D.W.9
-
17
-
-
0031048319
-
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 681-690
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
Liu, H.4
Zhang, L.5
Swaminathan, S.6
Bischofberger, N.7
Chen, M.S.8
Mendel, D.B.9
Tai, C.Y.10
Laver, W.G.11
Stevens, R.C.12
-
21
-
-
0030053758
-
Generation and characterization of variants of NWS/G70c influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu-5Ac2en
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 40-46
-
-
McKimm-Breschkin, J.L.1
Blick, T.J.2
Sahasrabudhe, A.3
Tiong, T.4
Marshall, D.5
Hart, G.J.6
Bethell, R.C.7
Penn, C.R.8
-
22
-
-
0031919227
-
Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS4071 protects mice and ferrets against influenza infection
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 640-646
-
-
Mendel, D.B.1
Tai, C.Y.2
Escarpe, P.A.3
Li, W.4
Sidwell, R.W.5
Huffman, J.H.6
Sweet, C.7
Jakeman, K.J.8
Merson, J.9
Lacy, S.A.10
Lew, W.11
Williams, M.A.12
Zhang, L.13
Chen, M.S.14
Bischofberger, N.15
Kim, C.U.16
-
26
-
-
0017151109
-
Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): Mechanism of action
-
(1976)
J. Gen. Virol.
, vol.33
, pp. 159-163
-
-
Palese, P.1
Compans, R.W.2
-
29
-
-
0032512327
-
Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections
-
(1998)
Lancet
, vol.352
, pp. 1877-1881
-
-
Silagy, C.A.1
-
31
-
-
0031787185
-
Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS4071
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 3234-3241
-
-
Tai, C.Y.1
Escarpe, P.A.2
Sidwell, R.W.3
Williams, M.A.4
Lew, W.5
Wu, H.6
Kim, C.U.7
Mendel, D.B.8
-
32
-
-
17744412173
-
Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza
-
(2000)
JAMA
, vol.283
, pp. 1016-1024
-
-
Treanor, J.J.1
Hayden, F.G.2
Vrooman, P.S.3
Barbarash, R.4
Bettis, R.5
Riff, D.6
Singh, S.7
Kinnersley, N.8
Ward, P.9
Mills, R.G.10
-
33
-
-
0027287506
-
Rational design of potent sialidase-based inhibitors of influenza virus replication
-
(1993)
Nature
, vol.363
, pp. 418-423
-
-
Von Itzstein, M.1
Wu, W.-Y.2
Kok, G.B.3
Pegg, M.S.4
Dyason, J.C.5
Jin, B.6
Phan, T.V.7
Smythe, M.L.8
White, H.F.9
Oliver, S.W.10
Colman, P.M.11
Varghese, J.N.12
Ryan, D.M.13
Woods, J.M.14
Bethell, R.C.15
Hotham, V.J.16
Cameron, J.M.17
Penn, C.R.18
-
34
-
-
0035848572
-
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1192-1201
-
-
Wang, G.T.1
Chen, Y.2
Wang, S.3
Gentles, R.4
Sowin, T.5
Kati, W.6
Muchmore, S.7
Giranda, V.8
Stewart, K.9
Sham, H.10
Kempf, D.11
Laver, W.G.12
-
36
-
-
0027162942
-
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro
-
(1994)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1473-1479
-
-
Woods, J.M.1
Bethell, R.C.2
Coates, J.A.V.3
Healy, N.4
Hiscox, S.A.5
Pearson, B.A.6
Ryan, D.M.7
Ticehurst, J.8
Tilling, J.9
Walcott, S.M.10
Penn, C.R.11
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