Hydrogen bonding and protein perturbation in β-lactam acyl-enzymes of Streptococcus pneumoniae penicillin-binding protein PBP2x

Biochemical Journal

Volumn 338, Issue 1, 1999, Pages 153-159

  Chittock, Roger S ^a   Ward, Simon ^a   Wilkinson, Alan Shaun ^a   Caspers, Patrick ^b   Mensch, Barbara ^b   Page, Malcolm G P ^b   Wharton, Christopher W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antibiotic; Benzylpenicillin; Infrared spectroscopy; Transpeptidase

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE; CARBONYL DERIVATIVE; CEFALOTIN; CEFTRIAXONE; CEPHALOSPORIN; CHYMOTRYPSIN; CLOXACILLIN; GAMMA GLUTAMYLTRANSFERASE; ORGANIC SOLVENT; PENICILLIN BINDING PROTEIN; PENICILLIN G;

ARTICLE; DEACYLATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROGEN BOND; INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STREPTOCOCCUS PNEUMONIAE;

ACYLATION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CARRIER PROTEINS; ESTERS; HYDROGEN BONDING; LIGANDS; PENICILLIN AMIDASE; PENICILLIN G; PENICILLIN-BINDING PROTEINS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, INFRARED; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 0033558272     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3380153     Document Type: Article

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