Differential cellular distribution of HIV-1 drug resistance in vivo: Evidence for infection of CD8+ T cells during HAART

Virology

Volumn 305, Issue 2, 2003, Pages 339-352

  Potter, Simon J ^a   Dwyer, Dominic E ^b   Saksena, Nitin K ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

CD8+ T cells; Compartmentalization; HAART; HIV 1; HIV 1 drug resistance

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; EFAVIRENZ; INDINAVIR; LAMIVUDINE; LOPINAVIR; NELFINAVIR; PROTEINASE; RNA DIRECTED DNA POLYMERASE; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ANALYTIC METHOD; ARTICLE; CELL COMPARTMENTALIZATION; CELL INFILTRATION; CELL SPECIFICITY; CELL TYPE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; GENE MUTATION; GENETIC ANALYSIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKOCYTE; MACROPHAGE; MONOCYTE; MONONUCLEAR CELL; PLASMA CELL; PREVALENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; T LYMPHOCYTE; VIRUS GENE; VIRUS ISOLATION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037455578     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1703     Document Type: Article

References (52)

1. Caliendo A. M., Savara A., An D., DeVore K., Kaplan J. C., D'Aquila R. T. Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication. J. Virol. 70:1996;2146-2153.
2. Chun T. W., Engel D., Mizeh S. B., Ehler L. A., Fauci A. S. Early establishment of a pool of latently infected, resting CD4+ T-cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA. 95:1998a;13193-13197.
3. Chun T. W., Engel D., Mizeh S. B., Ehler L. A., Fauci A. S. Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J. Exp. Med. 188:1998b;83-91.
4. Cocchi F., DeVico A. L., Garzino-Demo A., Arya S. K., Gallo R. C., Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 270:1995;1811-1815.
5. Collman R., Hassan N. F., Walker R., Godfrey B., Cutilli J., Hastings J. C., Friedman H., Douglas S. D., Nathanson N. Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types. J. Exp. Med. 170:1989;1149-1163.
6. Deng H., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di Marzio P., Marmon S., Sutton R. E. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 381:1996;661-666.
7. Englund G., Theodore T. S., Freed E. O., Engleman A., Martin M. A. Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J. Virol. 69:1995;3216-3219.
8. Eyre R. C., Zheng G., Kiessling A. A. Multiple drug resistance mutations in human immunodeficiency virus in semen but not blood of a man on antiretroviral therapy. Urology. 55:2000;591-598.
9. Felsenstein J. PHYLIP. Phylogeny interference package (version 3.2). Cladistics. 5:1989;164-166.
10. Finzi D., Hermankova M., Pierson T., Carruth L. M., Buck C., Chaisson R. E., Quinn T. C., Chadwick K., Margolick J., Brookmeyer R., Gallant J., Markowitz M., Ho D. D., Richman D. D., Siliciano R. F. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 278:1997;1295-1300.
11. Flamand L., Crowley R. W., Lusso P., Colombini-Hatch S., Margolis D. M., Gallo R. C. Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: Implications for HIV pathogenesis. Proc. Natl. Acad. Sci. USA. 95:1998;3111-3116.
12. Furtado M. R., Callaway D. S., Phair J. P., Kunstman K. J., Stanton J. L., Macken C. A., Perelson A. S., Wolinsky S. M. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N. Engl. J. Med. 340:1999;1614-1622.
13. Gendelman H. E., Meltzer M. S. Mononuclear phagocytes and the human immunodeficiency virus. Curr. Opin. Immunol. 2:1989-90;414-419.
14. Gulick R. M., Mellors J. W., Havlir D., Eron J. J., Gonzalez C., McMahon D., Richman D. D., Valentine F. T., Jonas L., Meibohm A., Emini E. A., Chodakewitz J. A. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N. Engl. J. Med. 337:1997;734-739.
15. Gupta P., Leroux C., Patterson B. K., Kingsley L., Rinaldo C., Ding M., Chen Y., Kulka K., Buchanan W., McKeon B., Montelaro R. Human immunodeficiency virus type 1 shedding pattern in semen correlates with the compartmentalization of viral quasi species between blood and semen. J. Infect. Dis. 182:2000;79-87.
16. Haddad D. N., Birch C., Middleton T., Dwyer D. E., Cunningham A. L., Saksena N. K. Evidence for late stage compartmentalization of HIV-1 resistance mutations between lymph node and peripheral blood mononuclear cells. AIDS. 14:2000;2273-2281.
17. Hammer S. M., Squires K. E., Hughes M. D., Grimes J. M., Demeter L. M., Currier J. S., Eron J. J. Jr., Feinberg J. E., Balfour H. H. Jr., Deyton L. R., Chodakewitz J. A., Fischl M. A. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N. Engl. J. Med. 337:1997;725-733.
18. Hirsch M. S., Conway B., D'Aquila R. T., Johnson V. A., Brun-Vezinet F., Clotet B., Demeter L. M., Hammer S. M., Jacobsen D. M., Kuritzkes D. R., Loveday C., Mellors J. W., Vella S., Richman D. D. Antiretroviral drug resistance testing in adults with HIV infection: Implications for clinical management. International AIDS Society-USA Panel. JAMA. 279:1998;1984-1991.
19. Hirschel B., Opravil M. The year in review: Antiretroviral treatment. AIDS. 13:1999;S177-S187.
20. Higgins D. G., Bleasby A. J., Fuchs R. CLUSTAL V: Improved software for multiple sequence alignment. Comput. Appl. Biosci. 8:1992;189-191.
21. Hoetelmans R. M. W. Sanctuary sites in HIV-1 infection. Antiviral Ther. 3:1998;13-17.
22. Imami N., Hardy G., Burton C., Pires A., Pido-Lopez J., Moss R., Gazzard B., Gotch F. Immune responses and reconstitution in HIV-1 infected individuals: Impact of anti-retroviral therapy, cytokines and therapeutic vaccination. Immunol. Lett. 79:2001;63-76.
23. Imlach S., McBreen S., Shirafuji T., Leen C., Bell J. E., Simmonds P. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. J. Virol. 75:2001;11555-11564.
24. Kepler T. B., Perelson A. S. Drug concentration heterogeneity facilitates the evolution of drug resistance. Proc. Natl. Acad. Sci. USA. 95:1998;11514-11519.
25. Kitchen S. G., Korin Y. D., Roth M. D., Landay A., Zack J. A. Costimulation of naïve CD8+ Lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J. Virol. 72:1998;9054-9060.
26. Kosalaraksa P., Kavlick M. F., Maroun V., Le R., Mitsuya H. Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay. J. Virol. 73:1999;5356-5363.
27. Lambotte O., Taoufik Y., De Goer M. G., Wallon C., Goujard C., Delfraissy J. F. Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy. J. Acquired Immune Defic. Syndr. 23:2000;114-119.
28. Lee S., Goldstein H., Baseler M., Adelsberger J., Golding H. Human immunodeficiency virus type 1 infection of mature CD3hiCD8+ thymocytes. J. Virol. 71:1997;6671-6676.
29. Livingstone W. J., Moore M., Innes D., Bell J. E., Simmonds P. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Lancet. 348:1996;649-654.
30. Martinez-Picado J., DePasquale M. P., Kartsonis N., Hanna G. J., Wong J., Finzi D., Rosenberg E., Gunthard H. F., Sutton L., Savara A., Petropoulos C. J., Hellmann N., Walker B. D., Richman D. D., Siliciano R., D'Aquila R. T. Antiretroviral resistance during successful therapy of HIV type 1 infection. Proc. Natl. Acad. Sci. USA. 97:2000;10948-10953.
31. McBreen S., Imlach S., Shirafuji T., Scott G. R., Leen C., Bell J. E., Simmonds P. Infection of the CD45RA+ (naive) subset of peripheral CD8+ lymphocytes by human immunodeficiency virus type 1 in vivo. J. Virol. 75:2001;4091-4102.
32. McElrath M. J., Steinman R. M., Cohn Z. A. Latent HIV-1 infection in enriched populations of blood monocytes and T cells from seropositive patients. J. Clin. Invest. 87:1991;27-30.
33. Omrani A. S., Pillay D. Multi-drug resistant HIV-1. J. Infect. 41:2000;5-11.
34. Orenstein J. M., Fox C., Wahl S. M. Macrophages as a source of HIV during opportunistic infections. Science. 276:1997;1857-1861.
35. Overbaugh J., Anderson R. J., Ndinya-Achola J. O., Kreiss J. K. Distinct but related human immunodeficiency virus type 1 variant populations in genital secretions and blood. AIDS Res. Hum. Retroviruses. 12:1996;107-115.
36. Palella F. J. Jr., Delaney K. M., Moorman A. C., Loveless M. O., Fuhrer J., Satten G. A., Aschman D. J., Holmberg S. D. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N. Engl. J. Med. 338:1998;853-860.
37. Poles M. A., Elliott J., Taing P., Anton P. A., Chen I. S. A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection. J. Virol. 75:2001;8390-8399.
38. Romano L., Venturi G., Catucci M., De Milito A., Valensin P. E., Zazzi M. Evaluation of cell-free and cell-associated peripheral blood human immunodeficiency virus type 1 RNA response to antiretroviral therapy. J. Infect. Dis. 179:1999;361-366.
39. Saha K., Zhang J., Gupta A., Dave R., Yimen M., Zerhouni B. Isolation of primary HIV-1 that target CD8+ T lymphocytes using CD8 as a receptor. Nat. Med. 7:2001;65-72.
40. Simmonds P., Zhang L. Q., McOmish F., Balfe P., Ludlam C. A., Brown A. J. Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: Implications for models of HIV pathogenesis. J. Virol. 65:1991;6266-6276.
41. Smit T. K., Wang B., Ng T., Osborne R., Brew B., Saksena N. K. Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): Evidence for neurotropic HIV variants. Virology. 279:2001;509-526.
42. Sonza S., Mutimer H. P., Oelrichs R., Jardine D., Harvey K., Dunne A., Purcell D. F., Birch C., Crowe S. M. Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy. AIDS. 15:2001;17-22.
43. Stingele K., Haas J., Zimmermann T., Stingele R., Hubsch-Muller C., Freitag M., Storch-Hagenlocher B., Hartmann M., Wildemann B. Independent HIV replication in paired CSF and blood viral isolates during antiretroviral therapy. Neurology. 56:2001;355-361.
44. Thompson J. D., Higgins D. G., Gibson T. J. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:1994;4673-4680.
45. Walker B. D., Flexner C., Birch-Limberger K., Fisher L., Paradis T. J., Aldovini A., Young R., Moss B., Schooley R. T. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA. 86:1989;9514-9518.
46. Wang Y. M., Dyer W. B., Workman C., Wang B., Sullivan J. S., Saksena N. K. Molecular evidence for drug-induced compartmentalization of HIV-1 quasispecies in a patient with periodic changes to HAART. AIDS. 14:2000;2265-2272.
47. Wong J. K., Hezareh M., Gunthard H. F., Havlir D. V., Ignacio C. C., Spina C. A., Richman D. D. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 278:1997a;1291-1295.
48. Wong J. K., Ignacio C. C., Torriani F., Havlir D., Fitch N. J., Richman D. D. In vivo compartmentalization of human immunodeficiency virus: Evidence from the examination of pol sequences from autopsy tissues. J. Virol. 71:1997b;2059-2071.
49. Yang L. P., Riley J. L., Carroll R. G., June C. H., Hoxie J., Patterson B. K., Ohshima Y., Hodes R. J., Delespesse G. Productive infection of neonatal CD8+ T lymphocytes by HIV-1. J. Exp. Med. 187:1998;1139-1144.
50. Zhang H., Dornadula G., Beumont M., Livornese L., Van Uitert B., Henning K., Pomerantz R. J. Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. N. Engl. J. Med. 339:1998;1803-1809.
51. Zhang L., Ramratnam B., Tenner-Racz K., He Y., Vesanen M., Lewin S., Talal A., Racz P., Perelson A. S., Korber B. T., Markowitz M., Ho D. D. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N. Engl. J. Med. 340:1999;1605-1613.
52. Zhu T., Muthui D., Holte S., Nickle D., Feng F., Brodie S., Hwangbo Y., Mullins J. I., Corey L. Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J. Virol. 76:2002;707-716.