Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome

Journal of the American College of Cardiology

Volumn 41, Issue 4, 2003, Pages 633-642

  Shimizu, Wataru ^a   Noda, Takashi ^a   Takaki, Hiroshi ^a   Kurita, Takashi ^a   Nagaya, Noritoshi ^a   Satomi, Kazuhiro ^a   Suyama, Kazuhiro ^a   Aihara, Naohiko ^a   Kamakura, Shiro ^a   Sunagawa, Kenji ^a   Echigo, Shigeyuki ^a   Nakamura, Kazufumi ^b   Ohe, Tohru ^b   Towbin, Jeffrey A ^c   Napolitano, Carlo ^d   Priori, Silvia G ^d  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN;

ACCURACY; ADOLESCENT; ADRENERGIC STIMULATION; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC APPROACH ROUTE; DRUG MECHANISM; ELECTROCARDIOGRAPHY; FEMALE; GENETIC DISORDER; HETEROZYGOTE; HUMAN; INFUSION; LONG QT SYNDROME; MALE; MUTATION; PRIORITY JOURNAL; QT INTERVAL;

EID: 0037454077     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(02)02850-4     Document Type: Article

References (21)

1. Zareba W, Moss AJ, Schwartz PJ, et al. Influence of the genotype on the clinical course of the long-QT syndrome. N Engl J Med 1998;339:960-5.
2. Moss AJ, Robinson JL, Gessman L, et al. Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome. Am J Cardiol 1999;84:876-9.
3. Ackerman MJ, Tester DJ, Porter CJ, Edwards WD. Molecular diagnosis of the inherited long-QT syndrome in a woman who died after near-drowning. N Engl J Med 1999;341:1121-5.
4. Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.
5. Priori SG, Napolitano C, Schwartz PJ. Low penetrance in the long-QT syndrome. Clinical impact. Circulation 1999;99:529-33.
6. Schechter E, Freeman CC, Lazzara R. After depolarizations as a mechanism for the long QT syndrome: electrophysiologic studies of a case. J Am Coll Cardiol 1984;3:1556-61.
7. Noda T, Takaki H, Kurita T, et al. Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. Eur Heart J 2002;23:975-83.
8. Ackerman MJ, Khositseth A, Tester DJ, Hejlik JB, Shen WK, Porter CB. Epinephrine-induced QT interval prolongation: a gene-specific paradoxical response in congenital long QT syndrome. Mayo Clin Proc 2002;77:413-21.
9. Keating M, Atkinson D, Dunn C, Timothy K, Vincent GM, Leppert M. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science 1991;252:704-6.
10. Schwartz PJ, Moss AJ, Vincent GM, Crampton RS. Diagnostic criteria for the long QT syndrome: an update. Circulation 1993;88:782-4.
11. Zhang L, Timothy KW, Vincent GM, et al. Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation 2000;102:2849-55.
12. Moss AJ, Schwartz PJ, Crampton RS, et al. The long QT syndrome: prospective longitudinal study of 328 families. Circulation 1991;84:1136-44.
13. Vincent GM, Timothy KW, Leppert M, Keating MT. The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome. N Engl J Med 1992;327:846-52.
14. Swan H, Saarinen K, Kontula K, Toivonen L, Viitasalo M. Evaluation of QT interval duration and dispersion and proposed clinical criteria in diagnosis of long QT syndrome in patients with a genetically uniform type of LQT1. J Am Coll Cardiol 1998;32:486-91.
15. Napolitano C, Schwartz PJ, Brown AM, et al. Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. J Cardiovasc Electrophysiol 2000;11:691-6.
16. Darbar D, Smith M, Morike K, Roden DM. Epinephrine-induced changes in serum potassium and cardiac repolarization and effects of pretreatment with propranolol and diltiazem. Am J Cardiol 1996;77:1351-5.
17. Brown MJ, Brown DC, Murphy MB. Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med 1983;309:1414-9.
18. Shimizu W, Antzelevitch C. Differential response to beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 2000;35:778-86.
19. Moss AJ, Zareba W, Hall WJ, et al. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation 2000;101:616-23.
20. Shimizu W, Tanabe Y, Aiba T, et al. Differential effects of beta-blockade on dispersion of repolarization in absence and presence of sympathetic stimulation between LQT1 and LQT2 forms of congenital long QT syndrome. J Am Coll Cardiol 2002;39:1984-91.
21. Burnes JE, Ghanem RN, Waldo AL, Rudy Y. Imaging dispersion of myocardial repolarization, I: comparison of body-surface and epicardial measures. Circulation 2001;104:1299-305.