Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome

American Journal of Cardiology

Volumn 84, Issue 8, 1999, Pages 876-879

  Moss, Arthur J ^a   Robinson, Jennifer L ^a   Gessman, Laura ^b   Gillespie, Robert ^c   Zareba, Wojciech ^a   Schwartz, Peter J ^d   Vincent, G Michael ^e   Benhorin, Jesaia ^f   Heilbron, Emanuela Locati ^g   Towbin, Jeffrey A ^h   Priori, Silvia G ^d   Napolitano, Carlo ^d   Zhang, Li ^e   Medina, Aharon ^f   Andrews, Mark L ^a   Timothy, Katherine ^e  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c MIDDLEBURY COLLEGE   (United States)

^d UNIVERSITY OF PAVIA   (Italy)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f BIKUR CHOLIM HOSPITAL   (Israel)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

^h Dept Clin Med Pathol P ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUDITORY STIMULATION; COMPARATIVE STUDY; EVOKED AUDITORY RESPONSE; EXPERIENCE; FEMALE; GENETIC ANALYSIS; GENOTYPE; HUMAN; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; STIMULUS RESPONSE; SWIMMING;

ACOUSTIC STIMULATION; ADULT; CHI-SQUARE DISTRIBUTION; DEATH, SUDDEN, CARDIAC; FEMALE; GENOTYPE; HEART ARREST; HUMANS; LONG QT SYNDROME; MALE; PROSPECTIVE STUDIES; REGISTRIES; SWIMMING; SYNCOPE;

EID: 0032874978     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(99)00458-0     Document Type: Article

References (25)

1. Jervell A., Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J. 54:1957;59-68.
2. Schwartz PJ, Zaza A, Locati E, Moss AJ. Stress and sudden death. Circulation 1991;83(suppl II):II-71-II-80.
3. Wellens H.J.J.J., Vermeulen A., Durrer D. Ventricular fibrillation occurring on arousal from sleep by auditory stimuli. Circulation. 46:1972;661-665.
4. Schwartz P.J., Periti M., Malliani A. The long QT syndrome. Am Heart J. 89:1975;378-390.
5. Moss AJ, Robinson J. Clinical features of idiopathic long QT syndrome. Circulation 1992;85(suppl I)I-140-I-144.
6. Garson A.J. Jr, Dick M.I. II, Fournier A., Gillette P.C., Hamilton R., Kugler J.D., Van Hare G.F., Vetter V., Vick G.W. The long QT syndrome in children an international study of 287 patients . Circulation. 87:1993;1866-1872.
7. Schwartz P.J., Locati E., Priori S.G., Zaza A. The idiopathic long QT syndrome. Zipes D.P., Jalife J. Cardiac Electrophysiology From Cell to Bedside . 1990;589-609 WB Saunders Co, Philadelphia, PA.
8. Ackerman M.J. The long QT syndrome ion channel diseases of the heart . Mayo Clin Proc. 73:1998;250-269.
9. Schwartz P.J., Bonazzi O., Locati E., Napolitano C., Sala S. Pathogenesis and therapy of the long QT syndrome. Ann NY Acad Sci. 644:1992;112-141.
10. Wang W., Curran M.E., Splawski I., Burn T.C., Millholland J.M., VanRaay T.J., Shen J., Timothy K.W., Vincent G.M., de Jager T., et al. Positional cloning of a novel potassium channel gene KVLQT1 mutations cause cardiac arrhythmias . Nat Genet. 12:1996;17-23.
11. Curran M.E., Splawski I., Timothy K., Vincent G.M., Green E., Keating M.T. A molecular basis for cardiac arrhythmia HERG mutations cause long QT syndrome . Cell. 80:1995;795-803.
12. Wang Q., Shen J., Splawski I., Atkinson D., Li Z., Robinson J.L., Moss A.J., Towbin J.A., Keating M.T. SCN5A mutations cause an inherited cardiac arrhythmia, long QT syndrome. Cell. 80:1995;805-811.
13. Ks. Nature Genetics. 17:1997;338-340.
14. Moss A.J., Zareba W., Benhorin J., Locati E.H., Hall W.J., Robinson J.L., Schwartz P.J., Towbin J.A., Vincent G.M., Lehmann M.H., et al. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation. 92:1995;2929-2934.
15. + channel blockade and to increases in heart rate implications for gene-specific therapy . Circulation. 92:1995;3381-3386.
16. Wilde A.A.M., Jongbloed R.J.E., Doevendans P.A., Duren D.R., Hauer R.N.W., van Langen I.M., vanTintelen J.P., Meyer H., Smeets H.J.M., Geelen J.L.M.C. Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol. 33:1999;327-332.
17. Vincent G.M., Timothy K.W., Leppert M., Keating M. The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome. N Engl J Med. 327:1992;846-852.
18. Zareba W., Moss A.J., Schwartz P.J., Vincent G.M., Robinson J.L., Priori S.G., Benhorin J., Locati E.H., Towbin J.A., Keating M.T., Lehmann M.H., Hall W.J. Influence of the genotype on the clinical course of the long QT syndrome. N Engl J Med. 339:1998;960-965.
19. Moss A.J., Schwartz P.J., Crampton R.S., Locati E., Carleen E. The long QT syndrome a prospective international study . Circulation. 71:1985;17-21.
20. Moss A.J., Schwartz P.J., Crampton R.S., Tzivoni D., Locati E.H., MacCluer J., Hall W.J., Weitkamp L., Vincent M., Garson A. Jr, Robinson J.L., Benhorin J., Choi S. The long QT syndrome prospective longitudinal study of 328 families . Circulation. 84:1991;1136-1144.
21. Roden D.M., Lazzara R., Rosen M., Schwartz P.J., Towbin T., Vincent G.M. Multiple mechanisms in the long-QT syndrome current knowledge, gaps, and future direction . Circulation. 94:1996;1996-2012.
22. El-Sherif N., Craelius W., Boutjdir M., Gough W.B. Early afterdepolarizations and arrhythmogenesis. J Cardiovasc Electrophysiol. 1:1990;145-160.
23. Antzelevich C., Sicouri S. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations role of M cells in the generation of U waves, triggered activity and torsade de pointes . J Am Coll Cardiol. 23:1994;259-277.
24. Splawski I., Timothy K.W., Vincent G.M., Atkinson Dl, Keating M.T. Molecular basis of the long-QT syndrome associated with deafness. N Engl J Med. 336:1997;1562-1567.
25. Neyroud N., Tesson F., Denjoy I., Leibovici M., Donger C., Barhanin J., Faure S., Gary F., Coumel P., Petit C., Schwartz K., Guicheney P. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nature Genetics. 15:1997;186-189.