Epinephrine-induced changes in serum potassium and cardiac repolarization and effects of pretreatment with propranolol and diltiazem

American Journal of Cardiology

Volumn 77, Issue 15, 1996, Pages 1351-1355

  Darbar, Dawood ^a   Smith, Martha ^a   Mörike, Klaus ^a   Roden, Dan M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CALCIUM; CATECHOLAMINE; DILTIAZEM; ELECTROLYTE; GLUCOSE; POTASSIUM; PROPRANOLOL;

ADULT; ARTICLE; CALCIUM CURRENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; HEART; HEART REPOLARIZATION; HUMAN; HUMAN EXPERIMENT; HYPOKALEMIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030585724     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(96)00204-4     Document Type: Article

References (22)

1. 1. Freedman RA, Swerdlow CD, Echt DS, Winkle RA, Soderholm-Difatte V, Mason JW. Facilitation of ventricular tachyrhythmia induction by isoproterenol, Am J Cardiol 1984;54:765-770.
2. 2. Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 1988;31:115-172.
3. 3. Morady F, Kou WH, Kadish AH, Toivonen LK, Kushner JA, Schmaltz S. Effects of epinephrine in patients with an accessory atrioventricular connection treated with quinidine. Am J Cardiol 1988;62:580-584.
4. 4. Jackman WM, Szabo B, Friday DJ, Margolis PD, Moulton K, Wang X, Patterson E, Lazzara R. Ventricular tachyarrhythmias related to early afterdepolarizations and triggered firing: relationship to QT interval prolongation and potential therapeutic role for calcium channel blocking agents. J Cardiovasc Electrophysiol 1990;1:170-195.
5. 5. Shimizu W, Ohe T, Kurita T, Tokuda T, Shimomura K. Epinephrine-induced ventricular premature complexes due to early afterdepolarizations and effects of verapamil and propranolol in a patient with congenital long QT syndrome. J Cardiovasc Electrophysiol 1994;5:438-444.
6. - channels isolated from the left ventricle of a patient with idiopathic long QT syndrome. Am Heart J 1993;126:1134-1141.
7. 7. D'Silva JL. The action of adrenaline on serum potassium. J Physiol 1934;82:393-398.
8. 8. Karlsberg RP, Cryer PE, Roberts R. Serial plasma catecholamine response early in the course of clinical acute myocardial infarction: relationship to infarct extent and mortality. Am Heart J 1981;102:24-29.
9. 2-receptor stimulation by circulating epinephrine. N Engl J Med 1983;309:1419.
10. 10. Fraser J, Nadeau JHJ, Robertson DH, Wood JJ. Regulation of human leucocyte beta receptors by endogenous catecholamines: relationship of leucocyte beta receptor density to the cardiac sensitivity to isoproterenol. J Clin Invest 1981;67:1777-1784.
11. 11. Naslund T, Silberstein DJ, Merrell, WJ, Nadeau JH, Wood AJJ. Low sodium, corrects an abnormality in beta-receptor-mediated arterial vasodilation in hypertensives: correlation with beta-receptor function in vivo. Clin Pharmacol Ther 1990;48:87-95.
12. 12. Coltart DJ, Shand DG. Plasma propranolol levels in the quantitative assessment of beta-adrenergic blockade in man. Br Med J 1970;3:731-734.
13. 13. Dean JW, Lab MJ. Effect of changes in load on monophasic action potential and segment length of pig heart in situ. Cardiovasc Res 1989;23:887-896.
14. 14. Hansen DE, Craig CS, Hondeghem, LM. Stretch-induced arrhythmias in the isolated canine ventricle: evidence for the importance of mechanoelectrical feedback. Circulation 1990;81:1094-1105.
15. 15. Cryer PE. Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system. N Engl J Med 1980;303:436-444.
16. 16. Clutter WE, Bier DM, Shah SD, Cryer PE. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hernodynamic actions in man, J Clin Invest 1980;66:94-101.
17. 17. Chistersen NJ, Vidaback J. Plasma catecholamines and carbohydrate metabolism in patients with acute myocardial infarction. J Clin Invest 1974;54:278-286.
18. 18. Yue DT, Herzig S, Marban E. Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes. Proc Nat Acad Sci 1990;87:742-747.
19. + currents in rat ventricular myocytes. Proc Nat Acad Sci 1988;84:8745-8760.
20. 20. Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PKS. Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E4031 in guinea pig myocytes: mechanism of action. Circ Res 1991;68:77-84.
21. 21. Harvey RD, Hume JR. Isoproterenol activates a chloride current, not the transient outward current, in rabbit ventricular myocytes. Am J Physiol 1989;247:C1177-C1181.
22. 22. Browne KF, Zipes DP, Heger JJ, Prystowsky EN. Influence of the autonomic nervous system on the Q-T interval in man. Am J Cardiol 1982;50:1099-1103.