Stabilization of salmon calcitonin by polystyrene nanoparticles having surface hydrophilic polymeric chains, against enzymatic degradation

International Journal of Pharmaceutics

Volumn 159, Issue 2, 1997, Pages 181-189

  Sakuma, Shinji ^a   Ishida, Yoshimasa ^b   Sudo, Rika ^a   Suzuki, Norio ^a   Kikuchi, Hiroshi ^a   Hiwatari, Ken Ichiro ^c   Kishida, Akio ^c   Akashi, Mitsuru ^c   Hayashi, Masahiro ^b  

^a DAIICHI SANKYO CO   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Absorption enhancement; Nanoparticle; Pepsin; Salmon calcitonin; Stabilization; Trypsin

Indexed keywords

NANOPARTICLE; PEPSIN A; POLY(N ISOPROPYLACRYLAMIDE); POLYMER; POLYSTYRENE DERIVATIVE; SALCATONIN; TRYPSIN;

ARTICLE; DRUG ABSORPTION; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; ENZYME DEGRADATION; GASTROINTESTINAL TRACT; PRIORITY JOURNAL;

EID: 0031574414     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00284-6     Document Type: Article

References (23)

1. Akashi M., Kirikihara I., Miyauchi N. Synthesis and polymerization of a styryl terminated oligovinylpyrrolidone macromonomer. Angew. Macromol. Chem. 132:1985;81-89.
2. Akashi M., Wada M., Yanase S., Miyauchi N. Polymer drugs and polymeric drugs, II. Synthesis of water dispersible microspheres having 5-fluorouracil and theophylline using a water soluble macromonomer. J. Polym. Sci. Polym. Lett. 27:1989;377-380.
3. Akashi M., Yanagi T., Yashima E., Miyauchi N. Graft copolymers having hydrophobic backbone and hydrophilic branches, HIV. A copolymerization study of water-soluble oligovinylpyrrolidone macromonomers. J. Poly. Sci. Polym. Chem. 27:1989;3521-3530.
4. Akashi M., Chao D., Yashima E., Miyauchi N. Graft copolymers having hydrophobic backbone and hydrophilic branches, V. Microspheres obtained by the copolymerization of poly(ethylene glycol) macromonomer with methyl methacrylate. J. Appl. Polym. Sci. 39:1990;2027-2030.
5. Ammoury N., Fessi H., Devissaguet J.P., Dubrasquet M., Benita S. Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(D,L-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats. Pharm. Res. 8:1991;101-105.
6. Borchard, G., Lueßen, H.L., de Boer, A.G., Verhoef, J.C., Lehr, C.M., Junginger, H.E., 1996. The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J. Control. Rel. 39, 131-138.
7. Capek I., Akashi M. On the kinetics of free radical polymerization of macromonomers. J. Macromol. Sci.-Rev. Macromol. Chem. Phys. C33:1993;369-436.
8. Chen M.Q., Kishida A., Akashi M. Graft copolymers having hydrophobic backbone and hydrophilic branches, XI. Preparation and thermosensitive properties of polystyrene microspheres having poly(N-isopropylacrylamide) branches on their surfaces. J. Polym. Sci. Polym. Chem. 34:1996;2213-2220.
9. Couvreur P., Puisieux F. Nano- and microparticles for the delivery of polypeptides and proteins. Adv. Drug Deliv. Rev. 10:1993;141-162.
10. Couvreur P., Dubernat C., Puisieux F. Controlled drug delivery with nanoparticles: current possibilities and future trends. Eur. J. Pharm. Biopharm. 41:1995;2-13.
11. Eldridge J.H., Hammond C.J., Meulbroek J.A., Staas J.K., Gilley R.M., Tice T.R. Controlled vaccine release in the gut-associated lymphoid tissues, I. Orally administered biodegradable microspheres target the Peyer's patches. J. Control. Rel. 11:1990;205-214.
12. Florence A.T., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Rel. 36:1995;39-46.
13. Haeberlin B., Gengenbacher T., Meinzer A., Fricker G. Cyclodextrins - useful excipients for oral peptide administration? Int. J. Pharm. 137:1996;103-110.
14. Hubert B., Atkinson J., Guerret M., Hoffman M., Devissaguet J.P., Maincent M. The preparation and acute antihypertensive effects of a nanocapsular form of darodipine, a dihydropyridine calcium entry blocker. Pharm Res. 8:1991;734-738.
15. Kreuter J. Peroral administration of nanoparticles. Adv. Drug Deliv. Rev. 7:1991;71-86.
16. Lueßen, H.L., Bohner, V., Pérard, D., Langguth, P., Verhoef, J.C., de Boer, A.G., Merkle, H.P., Junginger, H.E., 1996. Mucoadhesive polymers in peroral peptide drug delivery. V. Effect of poly(acrylates) on the enzymatic degradation of peptide drugs by intestinal brush border membrane vesicles. Int. J. Pharm. 141, 39-52.
17. Riza M., Tokura S., Iwasaki M., Yashima E., Kishida A., Akashi M. Graft copolymers having hydrophobic backbone and hydrophilic branches, X. Preparation and properties of water-dispersible polyanionic microspheres having poly(methacrylic acid) branches on their surfaces. J. Polym. Sci. Polym. Chem. 33:1995;1219-1225.
18. Roques M., Damgé C., Michel C., Staedel C., Cremel G., Hubert P. Encapsulation of insulin for oral administration preserves interaction of the hormone with its receptor in vitro. Diahetes. 41:1992;451-456.
19. Sakuma S., Suzuki N., Kikuchi H., Hiwatari K., Arikawa K., Kishida A., Akashi M. Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches. Int. J. Pharm. 149:1997;93-106.
20. Sakuma S., Suzuki N., Kikuchi H., Hiwatari K., Arikawa K., Kishida A., Akashi M. Absorption enhancement of orally administered salmon calcitonin by polystyrene nanoparticles having poly(N-isopropylacrylamide) benches on their surfaces. Int. J. Pharm. 158:1997;69-78.
21. Tomizawa H., Aramaki Y., Fujii Y., Hara T., Suzuki N., Yachi K., Kikuchi H., Tsuchiya S. Uptake of phosphatidylserine liposomes by rat Peyer's patches following intraluminal administration. Pharm. Res. 10:1993;549-552.
22. Weingarten C., Moufti A., Delattre J., Puisieux F., Couvreur P. Protection of insulin from enzymatic degradation by its association to liposomes. Int. J. Pharm. 26:1985;251-257.
23. Yamamoto A., Taniguchi T., Rikyuu K., Tsuji T., Fujita T., Murakami M., Muranishi S. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res. 11:1994;1496-1500.