Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2003, Pages 921-924

  Wei, Zhi Liang ^a   Petukhov, Pavel A ^a   Xiao, Yingxian ^a   Tückmantel, Werner ^a   George, Clifford ^b   Kellar, Kenneth J ^a   Kozikowski, Alan P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIBATIDINE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE;

ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RADIOASSAY; RAT; STRUCTURE ANALYSIS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN SUBUNITS; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037435058     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm025613w     Document Type: Article

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