Improving the nicotinic pharmacophore with a series of (isoxazole)methylene-1-azacyclic compounds: Synthesis, structure-activity relationship, and molecular modeling

Journal of Medicinal Chemistry

Volumn 42, Issue 24, 1999, Pages 4970-4980

  Tønder, Janne E ^a   Hansen, John Bondo ^a   Begtrup, Mikael ^b   Pettersson, Ingrid ^a   Rimvall, Karin ^a   Christensen, Birgitte ^a   Ehrbar, Ulrich ^a   Olesen, Preben H ^a  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTISINE; EPIBATIDINE; ISOXAZOLE DERIVATIVE; METHYL IODIDE; MUSCARINIC RECEPTOR; MUSCARONE; NICOTINE; NICOTINIC RECEPTOR;

ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; PHARMACOPHORE; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CEREBRAL CORTEX; CHEMISTRY, PHYSICAL; ELECTROSTATICS; HYDROGEN BONDING; ISOXAZOLES; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NICOTINE; NITROGEN; QUINUCLIDINES; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0033518276     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9910627     Document Type: Article

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