Design and synthesis of novel fluoropeptidomimetics as potential mimics of the transition state during peptide hydrolysis

Journal of Organic Chemistry

Volumn 68, Issue 3, 2003, Pages 1043-1049

  Annedi, Subhash C ^a   Li, Weiyong ^a   Samson, Sheeba ^a   Kotra, Lakshmi P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; ALKALINITY; ENZYME INHIBITION; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

POTENTIAL MIMICS;

AMINO ACIDS;

ALPHA FLUORO BETA AMINOETHANETHIOL DERIVATIVE; ALPHA FLUOROGLYCINE DERIVATIVE; CYSTEAMINE DERIVATIVE; FLUORINE DERIVATIVE; FLUOROPEPTIDOMIMETIC DERIVATIVE; GLYCINE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; AQUEOUS SOLUTION; ARTICLE; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; HYDROLYSIS; PEPTIDE ANALYSIS;

AMINO ACIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HYDROCARBONS, FLUORINATED; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PEPTIDES; PROTEASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037423176     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo026310c     Document Type: Article

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