Synthesis of carbonyl-bridged peptides containing an α-fluoroglycine residue

Chemical Communications

Volumn , Issue 9, 2000, Pages 785-786

  Takeuchi, Yoshio ^a   Kirihara, Kiyotoshi ^a   Kirk, Kenneth L ^b   Shibata, Norio ^a  

^a Med and Pharmaceutical University   (Japan)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; FLUOROACETIC ACID; GLYCINE; PEPTIDE;

AMINO ACID SYNTHESIS; ARTICLE; CHEMICAL REACTION; DIASTEREOISOMER; FLUORINATION; PROTON TRANSPORT; SYNTHESIS;

EID: 0034616523     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b001265n     Document Type: Article

References (13)

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11. 4. The solvent was removed under reduced pressure to give an oil that was purified by column chromatography on silica gel eluting with 60% ethyl acetate in hexane to give 4a (128 mg, 91%) as a colorless oil.
12. Dipeptides 4d-1 were the 1:1 mixtures of diastereomers, which were not separated.
13. A recent publication of similar types of bridged compounds; P. D. Bailey, A. N. Boe, S. R. Baker, J. Clayson, E. J. Murray and G. M. Rosair, Tetrahedron Lett., 1999, 40, 7557.