Design and synthesis of pseudo-Symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-Hydrazide isostere

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 93-96

  Hidaka, Koushi ^a   Kimura, Tooru ^a   Hayashi, Yoshio ^a   McDaniel, Keith F ^b   Dekhtyar, Tatyana ^b   Colletti, Lynn ^b   Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDRAZIDE DERIVATIVE; KNI 1166; KNI 1167; KNI 1224; KNI 1276; KNI 1277; KNI 1278; KNI 1279; KNI 1289; KNI 577; KNI 727; KNI 764; KYNOSTATIN 272; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; HYDRAZINE; HYDRAZINE DERIVATIVE; OLIGOPEPTIDE; PROTEINASE;

ARTICLE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PROTEINASE INHIBITION; CHEMISTRY; DRUG EFFECT; HUMAN; IC 50; MOLECULAR MIMICRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; HYDRAZINES; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037421005     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00848-X     Document Type: Article

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