Type II topoisomerase mutations in fluoroquinolone-resistant clinical strains of Pseudomonas aeruginosa isolated in 1998 and 1999: Role of target enzyme in mechanism of fluoroquinolone resistance

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 8, 2001, Pages 2263-2268

  Akasaka, T ^a   Tanaka, M ^a   Yamaguchi, A ^a   Sato, K ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; DNA TOPOISOMERASE IV; LEVOFLOXACIN; PROTEIN GYRC; PROTEIN GYRE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SITAFLOXACIN; SPARFLOXACIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; CONTROLLED STUDY; DRUG POTENCY; ENZYME MODIFICATION; GENE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRAIN DIFFERENCE;

ANTI-INFECTIVE AGENTS; DNA PRIMERS; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; FLUOROQUINOLONES; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA;

EID: 0034924146     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.8.2263-2268.2001     Document Type: Article

References (34)

1. Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV
2. Ouinolone resistance locus nfxD of Escherichia coli is a mutant allele of the pare gene encoding a subunit of topoisomerase IV
3. Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem
4. DNA gyrase, topoisomerase IV, and the 4-quinolones
5. nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa
6. A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium
7. Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria
8. Clinical applications of quinolones
9. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
10. Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa
11. Activities of newer fluoroquinolones against Streptococcus pneumoniae clinical isolates, including those with mutations in the gyrA, parC, and parE loci
12. New topoisomerase essential for chromosome segregation in E. coli
13. Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa
14. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa
15. Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa
16. Cloning and nucleotide sequence of Pseudomonas aeruginosa DNA gyrase gyrA gene from strain PAO1 and quinolone-resistant clinical isolates
17. DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities
18. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa
19. Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa
20. Mutations in the gyrA and parc genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa
21. Characterization of a mutation in the pare gene that confers fluoroquinolone resistance in Streptococcus pneumoniae
22. Mechanisms of fluoroquinolone resistance: An update, 1994-1998
23. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa
24. Multiple antibiotic resistance in Pseudomonas aeruginosa: Evidence for involvement of an efflux operon
25. Detection of gyrA mutations among 335 Pseudomonas aeruginosa strains isolated in Japan and their susceptibilities to fluoroquinolones
26. Quinolone resistance mutations in the GrlB protein of Staphylococcus aureus
27. Mutagenesis of E477 or K505 in the B′ domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage
28. Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli
29. Activities of antimicrobial agents against 5,180 clinical isolates obtained from 26 medical institutions during 1998 in Japan
30. DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa
31. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli
32. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli
33. Quinolone resistant mutations of the gyrA gene of Escherichia coli