Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia

European Neuropsychopharmacology

Volumn 13, Issue 3, 2003, Pages 187-197

  Daenen, Elisabeth W P M ^a   Wolterink, Gerrit ^a   Van Der Heyden, Jan A ^b   Kruse, Chris G ^b   Van Ree, Jan M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Amygdala; Animal model; Hippocampus; Prepulse inhibition; Schizophrenia; Startle

Indexed keywords

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY STIMULATION; BEHAVIOR; BRAIN INJURY; BRAIN MATURATION; CONTROLLED STUDY; DISEASE MODEL; HIPPOCAMPUS; LOCOMOTION; MALE; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; STARTLE REFLEX;

EID: 0037407003     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(03)00007-5     Document Type: Article

References (36)

1. Benes F.M., Berretta S. Amygdalo-entorhinal inputs to the hippocampal formation in relation to schizophrenia. Ann. N. Y. Acad. Sci. 911:2000;293-304.
2. Bouwmeester H., Wolterink G., Van Ree J.M. Neonatal development of projections from the basolateral amygdala to prefrontal, striatal, and thalamic structures in the rat. J. Comp. Neurol. 442:2002;239-249.
3. Braff D.L., Geyer M.A. Sensorimotor gating and schizophrenia. Human and animal model studies. Arch. Gen. Psychiatry. 47:1990;181-188.
4. Daenen E.W.P.M., Van der Heyden J.A., Kruse C.G., Wolterink G., Van Ree J.M. Adaptation and habituation to an open field and responses to various stressful events in animals with neonatal lesions in the amygdala or ventral hippocampus. Brain Res. 918:2001;153-165.
5. Daenen E.W., Wolterink G., Gerrits M.A., Van Ree J.M. Amygdala or ventral hippocampal lesions at two early stages of life differentially affect open field behaviour later in life; an animal model of neurodevelopmental psychopathological disorders. Behav. Brain Res. 131:2002;67-78.
6. Domeney A., Feldon J. The disruption of prepulse inhibition by social isolation in the Wistar rat: how robust is the effect? Pharmacol. Biochem. Behav. 59:1998;883-890.
7. Ellenbroek B.A., van den Kroonenberg P.T., Cools A.R. The effects of an early stressful life event on sensorimotor gating in adult rats. Schizophr. Res. 30:1998;251-260.
8. Fendt M., Schwienbacher I., Koch M. Amygdaloid N-methyl-D-aspartate and gamma-aminobutyric acid(A) receptors regulate sensorimotor gating in a dopamine-dependent way in rats. Neuroscience. 98:2000;55-60.
9. Johansson C., Jackson D.M., Zhang J., Svensson L. Prepulse inhibition of acoustic startle, a measure of sensorimotor gating: effects of antipsychotics and other agents in rats. Pharmacol. Biochem. Behav. 52:1995;649-654.
10. Khaing Z.Z., Weickert C.S., Weinberger D.R., Lipska B.K. Differential DNA damage in response to the neonatal and adult exitotoxic hippoampal lesion in rats. Eur. J. Neurosci. 12:2000;4424-4433.
11. Lewis D.A., Lieberman J.A. Catching up on schizophrenia: natural history and neurobiology. Neuron. 28:2000;325-334.
12. Lillrank S.M., Lipska B.K., Weinberger D.R. Neurodevelopmental animal models of schizophrenia. Clin. Neurosci. 3:1995;98-104.
13. Lipska B.K., Jaskiw G.E., Weinberger D.R. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology. 9:1993;67-75.
14. Lipska B.K., Jaskiw G.E., Weinberger D.R. The effects of combined prefrontal cortical and hippocampal damage on dopamine-related behaviors in rats. Pharmacol. Biochem. Behav. 48:1994;1053-1057.
15. Lipska B.K., Swerdlow N.R., Geyer M.A., Jaskiw G.E., Braff D.L., Weinberger D.R. Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology. 122:1995;35-43.
16. Lipska B.K., Weinberger D.R. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology. 23:2000;223-239.
17. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd Edition: 1986;Academic Press, San Diego, CA.
18. Rajarethinam R., DeQuardo J.R., Miedler J., Arndt S., Kirbat R., Brunberg J.A., Tandon R. Hippocampus and amygdala in schizophrenia: assessment of the relationship of neuroanatomy to psychopathology. Psychiatry Res. 108:2001;79-87.
19. Rosen J.B., Davis M. Enhancement of acoustic startle by electrical stimulation of the amygdala. Behav. Neurosci. 102:1988;195-202.
20. Saunders R.C., Kolachana B.S., Bachevalier J., Weinberger D.R. Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine. Nature. 393:1998;169-171.
21. Schroeder H., Grecksch G., Becker A., Bogerts B., Hoellt V. Alterations of the dopaminergic and glutamatergic neurotransmission in adult rats with postnatal ibotenic acid hippocampal lesion. Psychopharmacology. 145:1999;61-66.
22. Schwarzkopf S.B., Bruno J.P., Mitra T., Ison J.R. Effects of haloperidol and SCH 23390 on acoustic startle in animals depleted of dopamine as neonates: implications for neuropsychiatric syndromes. Psychopharmacology. 123:1996;258-266.
23. Selemon L.D., Goldman-Rakic P.S. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol. Psychiatry. 45:1999;17-25.
24. Swerdlow N.R., Braff D.L., Masten V.L., Geyer M.A. Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology. 101:1990;414-420.
25. Swerdlow N.R., Caine S.B., Braff D.L., Geyer M.A. The neural substrates of sensorimotor gating to the startle reflex: a review of recent findings and their implications. J. Psychopharmacol. 6:1992;176-190.
26. Swerdlow N.R., Caine S.B., Geyer M.A. Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats. Psychopharmacology. 108:1992;189-195.
27. Swerdlow N.R., Braff D.L., Taaid N., Geyer M.A. Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch. Gen. Psychiatry. 51:1994;139-154.
28. Swerdlow N.R., Lipska B.K., Weinberger D.R., Braff D.L., Jaskiw G.E., Geyer M.A. Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology. 122:1995;27-34.
29. Swerdlow N.R., Braff D.L., Geyer M.A. Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav. Pharmacol. 11:2000;185-204.
30. Verwer R.W., Van Vulpen E.H., Van Uum J.F. Postnatal development of amygdaloid projections to the prefrontal cortex in the rat studied with retrograde and anterograde tracers. J. Comp. Neurol. 376:1996;75-96.
31. Wan F.J., Swerdlow N.R. The basolateral amygdala regulates sensorimotor gating of acoustic startle in the rat. Neuroscience. 76:1997;715-724.
32. Wan R.Q., Corbett R. Enhancement of postsynaptic sensitivity to dopaminergic agonists induced by neonatal hippocampal lesions. Neuropsychopharmacology. 16:1997;259-268.
33. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 44:1987;660-669.
34. Wolterink G., Daenen E.W.P.M., Dubbeldam S., Gerrits M.A.F.M., Van Rijn R., Van Ree J.M. Early amygdala damage in the rat as a model for neurodevelopmental psychopathological disorders. Eur. Neuropsychopharmacol. 11:2001;51-59.
35. Wood G.K., Lipska B.K., Weinberger D.R. Behavioral changes in rats with early ventral hippocampal damage vary with age at damage. Brain Res. 101:1997;17-25.
36. Yeo R.A., Hodde Vargas J., Hendren R.L., Vargas L.A., Brooks W.M., Ford C.C., Gangestad S.W., Hart B.L. Brain abnormalities in schizophrenia-spectrum children: implications for a neurodevelopmental perspective. Psychiatry Res. 76:1997;1-13.