Differential DNA damage in response to the neonatal and adult excitotoxic hippocampal lesion in rats

European Journal of Neuroscience

Volumn 12, Issue 12, 2000, Pages 4424-4433

  Khaing, Z Z ^a   Weickert, C S ^a   Weinberger, D R ^a   Lipska, B K ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Animal model; Cell death; Ibotenic acid; Schizophrenia

Indexed keywords

DNA FRAGMENT; EXCITOTOXIN;

ADULTHOOD; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; DNA DAMAGE; HIPPOCAMPUS; HISTOLOGY; NEUROTOXICITY; NEWBORN; NICK END LABELING; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SURVIVAL TIME;

AGING; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CORPUS STRIATUM; DNA DAMAGE; DNA FRAGMENTATION; HIPPOCAMPUS; IBOTENIC ACID; IN SITU NICK-END LABELING; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034517412     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2000.01320.x     Document Type: Article

References (47)

1. Exaggerated MK-801-induced motor hyperactivity in rats with the neonatal lesion of the ventral hippocampus
2. Hippocampal formation
3. Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain
4. A role for N-methyl-D-Aspartate receptors in the regulation of synaptogenesis and expression of the polysialylated form of the neural cell adhesion molecule in the developing striatum
5. Apoptosis and necrosis after reversible focal ischemia: An in situ DNA fragmentation analysis
6. Naturally occurring cell death in the developing cerebral cortex of the rat. Evidence of apoptosis-associated internucleosomal DNA fragmentation
7. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
8. Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity
9. Disruption of latent inhibition in rats with postnatal hippocampal lesions
10. Rapid transneuronal degeneration and death of cortical neurons following removal of the olfactory bulb in adult rats
11. Regulation of N-methyl-D-aspartate (NMDA) receptor function during the rearrangement of developing neuronal connections
12. Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-D-aspartate neurotoxicity
13. Cortical reorganization of motor function: Studies on series of monkeys of various ages from infancy to maturity
14. Definition and incidence of apoptosis: A historical perspective
15. Sparing of function after neonatal frontal lesions correlates with increased cortical dendritic branching: A possible mechanism for the Kennard effect
16. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp 70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase
17. Prefrontal cortical and hippocampal modulation of haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat
18. Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat
19. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal hippocampal damage: A potential animal model of schizophrenia
20. Neonatal excitotoxic hippocampal damage in rats causes postpubertal. Changes in prepulse inhibition of startle and its disruption by apomorphine
21. Gonadectomy does not prevent novelty- or drug-induced hyperresponsiveness in rats with neonatal excitotoxic hippocampal damage
22. Subchronic treatment with haloperidol or clozapine in rats with neonatal excitotoxic hippocampal damage
23. To model a psychiatric disorder in animals: Schizophrenia as a reality test
24. Apoptosis in substantia nigra following developmental striatal excitotoxic injury
25. Differential brain area vulnerability to long-term subcortical excitotoxic lesions
26. Apoptosis, oncosis, and necrosis. An overview of cell death
27. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
28. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system
29. Neuronal death, a tradition of dying
30. Kainate-induced apoptotic cell death in hippocampal neurons
31. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
32. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
33. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
34. Programmed cell death and the control of cell survival: Lessons from the nervous system
35. Anchorage dependence, integrins, and apoptosis
36. Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood
37. In vitro and in vivo pharmacology of trans- and cis-l-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects
38. Necrosis and apoptosis: Distinct modes of cell death with fundamentally different significance
39. The limbic region. I. The septohippocampal system
40. Increased sensitivity to the sensorimotor gating disruptive effects of apomorphine after lesions of frontal cortex or hippocampus in adult rats
41. Apoptosis and its relation to the cell cycle in the developing cerebral cortex
42. Quinolinate-induced injury is enhanced in developing rat brain
43. Glutamate metabotropic receptor agonist 1S,3R-ACPD induces internucleosomal DNA fragmentation and cell death in rat striatum
44. Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
45. Heterogeneity in the dorsal subiculum of the rat: Distinct neuronal zones project to different cortical and subcortical targets
46. Behavioral changes in rats with early ventral hippocampal damage vary with age at damage