Effects of haloperidol and SCH 23390 on acoustic startle in animals depleted of dopamine as neonates: Implications for neuropsychiatric syndromes

Psychopharmacology

Volumn 123, Issue 3, 1996, Pages 258-266

  Schwarzkopf, S B ^a,b   Bruno, J P ^c   Mitra, T ^c   Ison, J R ^b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Acoustic startle reflex; D1 D2 receptors; Dopamine; Neonatal; Schizophrenia

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; APOMORPHINE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; OXIDOPAMINE;

ACOUSTIC REFLEX; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG SENSITIVITY; MALE; MONOAMINE METABOLISM; NEUROPSYCHIATRY; NEWBORN; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; ANIMALS, NEWBORN; DOPAMINE; HALOPERIDOL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA; STARTLE REACTION;

EID: 0030044471     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246580     Document Type: Article

References (65)

1. 2 receptor mediation in rats depleted of dopamine as neonates. Dev Psychobiol 25: 475-495
2. Bakshi VP, Swerdlow NR, Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271: 787-794
3. Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47: 181-188
4. Braff DL, Stone C, Callaway E, Geyer MA, Glick ID, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15: 339-343
5. Breese GR, Traylor TD (1971) Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine. Br J Pharmacol 42: 88-99
6. Breese GR, Baumeister AA, McCown TJ, Emerick SG, Frye GD, Crotty K, Mueller RA (1984) Behavioral difference between neonatal and adult 6-hydroxy-dopamine-treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine. J Pharmacol Exp Ther 231: 343-354
7. Breese GR, Napier TC, Mueller RA (1985) Dopamine agonist-induced locomotor activity in rats treated with 6-hydroxydopamine at differing ages: functional supersensitivity of D-1 receptors in neonatally lesioned rats. J Pharmacol Exp Ther 234: 447-455
8. 2 receptors in rats depleted of dopamine as neonates Psychopharmacology (in press)
9. Brus R, Kostrzewa RM, Perry KW, Fuller RW (1994) Supersensitization of the oral response to SKF 38393 neonatal 6-hydroxydopamine-lesioned rats is eliminated by neonatal 5,7-dihydroxytryptamine treatment. J Pharmacol Exp Ther 268: 231-237
10. Buchsbaum MS, Ingvar DH, Kessler R, Waters RN, Cappelletti J, van Kammen DP, King AC, Johnson JL, Manning RG, Flynn RW, Mann LS, Bunney WE, Sokoloff L (1982) Cerebral glucography with positron tomography. Use in normal subjects and in patients with schizophrenia. Arch Gen Psychiatry 39: 251-259
11. Butler RW, Jenkins MA, Geyer MA, Braff DL (1991) Wisconsin card sorting deficits and diminished sensorimotor gating in a discrete subgroup of schizophrenic patients. In: Tamminga CA, Schulz SC (eds) Advances in neuropsychiatry and psychopharmacology, vol. 1: schizophrenia research. Raven Press, New York, pp 163-168
12. Cadenhead KS, Geyer MA, Braff DL (1993) Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am J Psychiatry 150: 1862-1867
13. Castaneda E, Whishaw IQ, Lermer L, Robinson TE (1990) Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood. Brain Res 508: 30-39
14. Council for International Organizations of Medical Sciences (1985) International guiding principles for biomedical research involving animals. CIOMS, Geneva. Reprinted in: Beauchamp TL, Walters L (eds) Contemporary issues in bioethics, 3rd edn. Wadsworth, Belmont, Calif., pp 423-424
15. Council for International Organizations of Medical Sciences (1985) International guiding principles for biomedical research involving animals. CIOMS, Geneva. Reprinted in: Beauchamp TL, Walters L (eds) Contemporary issues in bioethics, 3rd edn. Wadsworth, Belmont, Calif., pp 423-424
16. 2 dopamine receptor classification and its functional implications. Synapse 1: 347-388
17. 1-dopamine agonist following repeated administration to neonatal 6-OHDA-lesioned rats. J Neurosci 9: 125-133
18. 1 dopamine receptors. Neuropsychopharmacology 7: 95-103
19. 2 receptors. Psychopharmacology 74: 122-124
20. Davis M, Aghajanian GK, (1976) Effects of apomorphine and haloperidol on the acoustic startle response in rats. Psychopharmacology 47: 217-223
21. Davis M, Mansbach RS, Swerdlow NR, Campeau S, Braff DL, Geyer MA (1990) Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats. Psychopharmacology 102: 1-4
22. Dawson ME, Hazlett EA, Filion DL, Nuechterlein KH, Schell AM (1993) Attention and schizophrenia: impaired modulation of the startle reflex. J Abnorm Psychol 102: 633-641
23. Duncan GE, Criswell HE, McCown TJ, Paul IA, Mueller RA, Breese GR (1987) Behavioral and neurochemical responses to haloperidol and SCH-23390 in rats treated neonatally or as adults with 6-hydroxydopamine. J Pharmacol Exp Ther 243: 1027-1034
24. 2 receptor in PET study of schizophrenia. Arch Gen Psychiatry 44: 671-672
25. 2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology 99: S28-S31
26. Farkas T, Wolf AP, Jaeger J, Brodie JD, Christman DR, Fowler JS (1984) Regional Brain glucose metabolism in chronic schizophrenia: a positron emission transaxial tomographic study. Arch Gen Psychiatry 41: 293-300
27. Geyer MA, Braff DL (1982) Habitation of the blink reflex in normals and schizophrenic patients. Psychophysiology 19: 1-6
28. Geyer MA, Braff DL (1987) Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophr Bull 13: 643-667
29. Glowinski J, Tassin JP, Thierry AM (1984) The mesocortico-prefrontal dopaminergic neurons. Trends Neurosci 7: 415-418
30. Grace AA (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41: 1-24
31. Graham F (1975) The more or less startling effects of weak prestimuli. Psychophysiology 12: 238-248
32. Grillon C, Ameli R, Charney DS, Krystal J, Braff DL (1992) Startle gating deficits occur across prepulse in schizophrenic patients. Biol Psychiatry 32: 939-943
33. 1 receptor antagonism in schizophrenia: is there reduced risk of extrapyramidal side-effects. Trends Pharmacol Sci 11: 406-410
34. Hoffman DC, Donovan H (1994) D-1 and D-2 dopamine receptor antagonists reverse prepulse inhibition deficits in an animal model of schizophrenia. Psychopharmacology 115: 447-453
35. Houston JP, Maas JW, Bowden CL, Contreras SA, McIntyre KL, Javors M (1986) Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia. Psychiatry Res 19: 207-214
36. Ison JR, Hammond GR (1971) Modification of the startle reflex in the rat by changes in the auditory and visual environments. J Comp Physiol Psychol 75: 435-452
37. Ison JR (1990) Behavioral methods applicable to laboratory animals and humans. In: Johnson BL, Anger WK, Durao A, Xintaras C (eds) Advances in neurobehavioral toxicology: applications in environmental and occupational health. Lewis Publishers, Chelsea, Mich., pp 389-401
38. 2 receptor contributions to ingestive and locomotor behavior are altered after dopamine depletions in neonatal rats. Neurosci Lett 118: 120-123
39. Keppel G (1982) Design and analysis of experiments: a researcher's handbook, 2nd edn. Prentice-Hall, Englewood Cliffs, New Jersey, pp 144-166
40. Kostrzewa RM, Gong L, Brus R (1993) Serotonin (5-HT) systems mediate dopamine (DA) receptor supersensitivity. Acta Neurobiol Exp 53: 31-41
41. Lindstrom LH (1985) Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: correlations to symptomatology and family history. Psychiatry Res 14: 265-273
42. Manshach RS (1991) Effects of NMDA receptor ligands on sensorimotor gating in the rat. Eur J Pharmacol 202: 61-66
43. Mansbach RS, Geyer MA (1991) Parametric determinants in prestimulus modification of acoustic startle: interaction with ketamine. Psychopharmacology 105: 162-168
44. Mansbach RS, Geyer MA, Braff DL (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94: 507-514
45. 2 receptor agonist disrupts sensorimotor gating in rats: implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology 3: 211-218
46. Perry W, Braff DL (1994) Information-processing deficits and thought disorder in schizophrenia. Am J Psychiatry 151: 363-367
47. Potter BM, Bruno JP (1991) Infant rats depleted of brain dopamine as neonates exhibit normal independent. Dev Psychobiol 24: 65-79
48. Rigdon GC, Viik K (1991) Prepulse inhibition as a screening test for potential antipsychotics. Drug Dev Res 23: 91-99
49. SAS Institute (1985) SAS/STAT guide for personal computers, Version 6.03 Edition. SAS Institute Inc., Cary, North Carolina
50. Schallen T, Petrie BF, Whishaw IQ (1989) Neonatal dopamine depletion: spared and unspared sensorimotor and attentional disorders and effects of further depletion in adulthood. Psychobiology 17: 386-396
51. Schwarzkopf SB, Mitra T, Bruno JP (1992) Sensory gating in rats depleted of dopamine as neonates: potential relevance to findings in schizophrenic patients. Biol Psychiatry 31: 759-773
52. Schwarzkopf SB, Bruno JP, Mitra T (1993) Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions. Prog Neuropsychopharmacol Biol Psychiatry 17: 1023-1036
53. Seeman P, Ulpian C, Bergeron C, Riederer P, Jellinger K, Gabriel E, Reynolds BP, Tourtellotte WW (1984) Bimodal distribution of dopamine receptor densities in brains of schizophrenics. Science 225: 728-731
54. 2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain. Proc Natl Acad Sci USA 86: 10156-10160
55. 4 receptors elevated in schizophrenia. Nature 365: 441-445
56. Swerdlow NR, Braff DL, Geyer MA, Koob GF (1986) Central dopamine hyperactivity in rats mimics abnormal sensory gating of the acoustic startle response in schizophrenics. Biol Psychiatry 21: 23-33
57. Swerdlow NR, Braff DL, Masten VL, Geyer MA (1990) Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology 101: 414-420
58. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994) Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51: 139-154
59. van Kammen DP, van Kammen WB, Mann LS, Seppda T, Linnoila M (1986) Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy. Arch Gen Psychiatry 43: 978-983
60. 2-like dopamine receptor systems. In: Niznik HB (ed) Dopamine receptors and transporters: pharmacology, structure, and function. Marcel Dekker, New York, pp 511-537
61. Weihmuller FB, Bruno JP (1989) Drinking behavior and motor function in rat pups depleted of brain dopamine during development. Dev Psychobiol 22: 101-113
62. Weinberger DR (1987) Implication of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660-668
63. Weinberger DR, Berman KF, Zec RF (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43: 114-124
64. 2 dopamine receptors in drug-naive schizophrenics. Science 234: 1558-1563
65. Young KA, Ranall PK, Wilcox RE (1991) Dose and time response analysis of apomorphine's effect on prepulse inhibition of acoustic startle. Behav Brain Res 42: 43-48