A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts

Archives of Gerontology and Geriatrics

Volumn 36, Issue 3, 2003, Pages 203-219

  Matuoka, Koozi ^a,b   Chen, Kuang Yu ^b   Takenawa, Tadaomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Cellular aging; Cellular morphology; Human diploid fibroblasts; Hydrogen peroxide; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CELL ENZYME; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN SUBUNIT;

ARTICLE; CELL AGING; CELL CULTURE; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DIPLOIDY; DRUG INHIBITION; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; MORPHOGENESIS; OXIDATIVE STRESS; PERIKARYON; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SUBSPECIES;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGE FACTORS; CELL AGING; CELL CYCLE; CELL LINE; CELLS, CULTURED; CHROMATOGRAPHY, THIN LAYER; CHROMONES; CULTURE MEDIA; DENSITOMETRY; DIPLOIDY; DNA PRIMERS; FIBROBLASTS; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; MORPHOLINES; NUCLEIC ACID AMPLIFICATION TECHNIQUES; OXIDATIVE STRESS; PHENOTYPE; PHOSPHATIDYLINOSITOLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 0037405401     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(02)00151-6     Document Type: Article

References (31)

1. - free radicals in differentiation of cultured human fibroblasts. Arch. Gerontol. Geriatr. 31:2000;233-242.
2. Beckman K.B., Ames B.N. The free radical theory of aging matures. Physiol. Rev. 78:1998;547-581.
3. Cantrell D.A. Phosphoinositide 3-kinase signalling pathways. J. Cell Sci. 114:2001;1439-1445.
4. Chang Z.F., Huang D.Y. Regulation of thymidine kinase expression during cellular senescence. J. Biomed. Sci. 8:2001;176-183.
5. Chen Q., Ames B.N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. USA. 91:1994;4130-4134.
6. 2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem. J. 332:1998;43-50.
7. Chen Q.M., Prowse K.R., Tu V.C., Purdom S., Linskens M.H. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp. Cell Res. 265:2001;294-303.
8. Collado M., Medema R.H., Garcia-Cao I., Dubuisson M.L., Barradas M., Glassford J., Rivas C., Burgering B.M., Serrano M., Lam E.W. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J. Biol. Chem. 275:2000;21960-21968.
9. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., Peacock M., Campisi J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA. 92:1995;9363-9367.
10. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature. 408:2000;239-247.
11. Hiroyama M., Takenawa T. Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis. J. Biol. Chem. 274:1999;29172-29180.
12. Itoh T., Ishihara H., Shibasaki Y., Oka Y., Takenawa T. Autophosphorylation of type I phosphatidylinositol phosphate kinase regulates its lipid kinase activity. J. Biol. Chem. 275:2000;19389-19394.
13. Kim M.S., Lim W.K., Cha J.G., An N.H., Yoo S.J., Park J.H., Kim H.M., Lee Y.M. The activation of PI 3-K and PKCζ in PMA-induced differentiation of HL-60 cells. Cancer Lett. 171:2001;79-85.
14. Kim H., You S., Farris J., Kong B.W., Christman S.A., Foster L.K., Foster D.N. Expression profiles of p53-, p16(INK4a)-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cells. Exp. Cell Res. 272:2002;199-208.
15. Klesse L.J., Parada L.F. Trks: signal transduction and intracellular pathways. Microsc. Res. Tech. 45:1999;210-216.
16. 2 and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase. J. Biochem. (Tokyo). 126:1999;1136-1143.
17. Krasilnikov M.A. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry (Mosc.). 65:2000;59-67.
18. Matuoka K., Takenawa T. Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110α and WRN during fibroblast aging in vitro. Biochim. Biophys. Acta. 1401:1998;211-215.
19. Matuoka K., Chen K.Y. Possible role of subunit A of nuclear factor Y (NF-YA) in normal human diploid fibroblasts during senescence. Biogerontology. 1:2000;261-271.
20. Matuoka, K., Chen, K.Y., 2002. Telomerase positive human diploid fibroblasts are resistant to replicative senescence but not premature senescence induced by chemical reagents. Biogerontology, 3, in press.
21. Matuoka K., Chen K.Y., Takenawa T. Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation. Cell. Mol. Life Sci. 58:2001;2108-2116.
22. Morris J.Z., Tissenbaum H.A., Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 382:1996;536-539.
23. Roymans D., Slegers H. Phosphatidylinositol 3-kinases in tumor progression. Eur. J. Biochem. 268:2001;487-498.
24. Rozycka M., Lu Y.-J., Brown R.A., Lau M.R., Shipley J.M., Fry M.J. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics. 54:1998;569-574.
25. Sarner S., Kozma R., Ahmed S., Lim L. Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells. Mol. Cell. Biol. 20:2000;158-172.
26. Serunian L.A., Auger K.R., Cantley L.C. Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol. 198:1991;78-87.
27. Stephens L.R., Eguinoa A., Erdjument-Bromage H., Lui M., Cooke F., Coadwell J., Smrcka A.S., Thelen M., Cadwallader K., Tempst P., Hawkins P.T. The Gβγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 89:1997;105-114.
28. Strum J.C., Ghosh S., Bell R.M. Lipid second messengers. A role in cell growth regulation and cell cycle progression. Adv. Exp. Med. Biol. 407:1997;421-431.
29. Tresini M., Mawal-Dewan M., Cristofalo V.J., Sell C. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. Cancer Res. 58:1998;1-4.
30. Van der Kaay J., Beck M., Gray A., Downes C.P. Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses. J. Biol. Chem. 274:1999;35963-35968.
31. Wymann M.P., Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta. 1436:1998;127-150.