Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110α and WRN during fibroblast aging in vitro

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1401, Issue 2, 1998, Pages 211-215

  Matuoka, Koozi ^a   Takenawa, Tadaomi ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cell density; Cell growth; Cellular aging; MRNA; RT PCR; Signal transduction

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

AGING; ARTICLE; CELL DENSITY; DOWN REGULATION; ENZYME INDUCTION; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BLOTTING, NORTHERN; CELL AGING; CELLS, CULTURED; DNA HELICASES; DOWN-REGULATION; FIBROBLASTS; GENE EXPRESSION REGULATION; GRB2 ADAPTOR PROTEIN; HUMANS; ONCOGENE PROTEINS; POLYMERASE CHAIN REACTION; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CRK; RECQ HELICASES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0032481342     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(97)00133-X     Document Type: Article

References (20)

1. Smith J.R., Pereira S.O. Science. 273:1996;63-67.
2. Cristofalo V.J., Pignolo R.J. Exp. Gerontol. 31:1996;111-123.
3. Vojta P.J., Barrett J.C. Biochim. Biophys. Acta. 1242:1995;29-41.
4. Autexier C., Greider C.W. Trends Biochem. Sci. 21:1996;387-391.
5. Hannun Y.A. Science. 274:1996;1855-1859.
6. Pang J.H., Chen K.Y. J. Cell. Physiol. 160:1994;531-538.
7. Linskens M.H., Feng J., Andrews W.H., Enlow B.E., Saati S.M., Tonkin L.A., Funk W.D., Villeponteau B. Nucl. Acids Res. 23:1995;3244-3251.
8. Pawson T. Nature. 373:1995;573-580.
9. Hunter T. Cell. 88:1997;333-346.
10. Matuoka K., Mitsui Y. Mech. Age. Develop. 15:1981;153-163.
11. Matuoka K., Mitsui Y., Murota S. Cell Struct. Funct. 9:1984;357-367.
12. Strohman R.C., Moss P.S., Micou E.J., Spector D., Przybyla A., Paterson B. Cell. 10:1977;265-273.
13. Matuoka K., Shibata M., Yamakawa A., Takenawa T. Proc. Nat. Acad. Sci. USA. 89:1992;9015-9019.
14. Hamilton J.W., Louis C.A., Doherty K.A., Hunt S.R., Reed M.J., Treadwell M.D. Mol. Carcinogen. 8:1993;34-43.
15. Chang H.W., Aoki M., Fruman D., Auger K.R., Bellacosa A., Tsichlis P.N., Cantley L.C., Roberts T.M., Vogt P.K. Science. 276:1997;1848-1850.
16. Yu C.E., Oshima J., Fu Y.H., Wijsman E.M., Hisama F., Alisch R., Matthews S., Nakura J., Miki T., Ouais S., Martin G.M., Mulligan J., Schellenberg G.D. Science. 272:1996;258-262.
17. Morris J.Z., Tissenbaum H.A., Ruvkun G. Nature. 382:1996;536-539.
18. Namba M., Nishitani K., Kimoto T. Gann. 71:1980;300-307.
19. van der Geer P., Wiley S., Lai V.K., Olivier J.P., Gish G.D., Stephens R., Kaplan D., Shoelson S., Pawson T. Curr. Biol. 5:1995;404-412.
20. Matsuda M., Tanaka S., Nagata S., Kojima A., Kurata T., Shibuya M. Mol. Cell. Biol. 12:1992;3482-3489.