Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells

Current Biology

Volumn 8, Issue 24, 1998, Pages 1331-1334

  Rosen, Kirill ^a   Rak, Janusz ^a   Jin, Jing ^b   Kerbel, Robert S ^a   Newman, Michael J ^c   Filmus, Jorge ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Ontogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0032481146     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(07)00564-7     Document Type: Article

References (16)

1. Ruoslahti E, Reed JC: Anchorage dependence, integrins, and apoptosis. Cell 1994, 77:477-478.
2. Frisch SM, Ruoslahti E: Integrins and anoikis. Curr Opin Cell Biol 1997, 9:701-706.
3. Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994, 124:619-626.
4. Rak J, Mitsuhashi Y, Erdos V, Huang S-N, Filmus J, Kerbel RS: Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant C-H-ras oncogene. J Cell Biol 1995, 131:1587-1598.
5. Krajewska M, Moss SF, Krajewski S, Song K, Holt PR, Reed JC: Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 1996, 56:2422-2427.
6. Krajewski S, Krajewska M, Reed JC: Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. Cancer Res 1996, 56:2849-2855.
7. Moss SF, Agarwal B, Arber N, Guan RJ, Krajewska M, Krajewski S, et al.: Increased intestinal Bak expression results in apoptosis. Biochem Biophys Res Commun 1996, 223:199-203.
8. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J: Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 1997, 16:2783-2793.
9. Filmus J, Zhao J, Buick RN: Overexpression of H-ras oncogene induces resistance to the growth inhibitory action of transforming growth factor beta-1 (TGF-β1) and alters the number and type of TGF-β1 receptors in rat intestinal epithelial cell clones. Oncogene 1992, 7:521-526.
10. Filmus J, Robles AI, Shi W, Wong MJ, Colombo LL, Conti CJ: Induction of cyclin D1 overexpression by activated ras. Oncogene 1994, 9:3627-3633.
11. Shirasawa AS, Furuse M, Yokoyama N, Sasazuki T: Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 1993, 260:85-88.
12. Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994, 269:5241-5248.
13. Allesi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR: PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995, 270:27489-27495.
14. Pang L, Sawada T, Decker SJ, Saltiel AR: Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 1995, 270:13585-13588.
15. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al.: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
16. Del Peso L, Gonzales-Garcia M, Page C, Herrera R, Nunez G: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278:687-689.