Involvement of vacuolar H+-ATPase in incorporation of risedronate into osteoclasts

Bone

Volumn 32, Issue 4, 2003, Pages 341-349

  Takami, M ^a   Suda, K ^a,b   Sahara, T ^a   Itoh, K ^a   Nagai, K ^b,c   Sasaki, T ^a   Udagawa, N ^d   Takahashi, N ^d  

^a SHOWA UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c CHUBU UNIVERSITY   (Japan)

^d MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Acidification; Actin ring; Bisphosphonate; Osteoclast; Ruffled border; Vacuolar H+ ATPase

Indexed keywords

BAFILOMYCIN A1; CALCITONIN; ETIDRONIC ACID; MATRIX PROTEIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RISEDRONIC ACID;

ANIMAL CELL; ARTICLE; BONE DEMINERALIZATION; CELL ACTIVITY; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENTIN; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; MALE; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST;

EID: 0037384718     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(03)00024-3     Document Type: Article

References (46)

1. Chambers T.J. Regulation of the differentiation and function of osteoclasts. J Pathol. 192:2000;4-13.
2. Teitelbaum S.L. Bone resorption by osteoclasts. Science. 289:2000;1504-1508.
3. Roodman G.D. Cell biology of the osteoclast. Exp Hematol. 27:1999;1229-1241.
4. Lakkakorpi P.T., Horton M.A., Helfrich M.H., Karhukorpi E.K., Väänänen H.K. Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface. J Cell Biol. 115:1991;1179-1186.
5. Duong L.T., Lakkakorpi P., Nakamura I., Rodan G.A. Integrins and signaling in osteoclast function. Matrix Biol. 19:2000;97-105.
6. 3 integrin in osteoclast migration and formation of the sealing zone. J Cell Sci. 112:1999;3985-3993.
7. Blair H.C., Teitelbaum S.L., Ghiselli R., Gluck S. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 245:1989;855-857.
8. +-ATPase type in the ruffled borders of osteoclasts. J Cell Biol. 111:1990;1305-1311.
9. Tezuka K., Nemoto K., Tezuka Y., Sato T., Ikeda Y., Kobori M., Eguchi H H., Hakeda Y., Kumegawa M. Identification of matrix metalloproteinase 9 in rabbit osteoclasts. J Biol Chem. 269:1994;15006-15009.
10. Dodds R.A., Connor J.R., Drake F.H., Gowen M. Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues. Arthritis Rheum. 42:1999;1588-1593.
11. Sasaki T., Ueno-Matsuda E. Cysteine-proteinase localization in osteoclasts an immunocytochemical study . Cell Tissue Res. 271:1993;177-179.
12. Nesbitt S.A., Horton M.A. Trafficking of matrix collagens through bone-resorbing osteoclasts. Science. 276:1997;266-269.
13. Salo J., Lehenkari P., Mulari M., Metsikko K., Väänänen H.K. Removal of osteoclast bone resorption products by transcytosis. Science. 276:1997;270-273.
14. Väänänen H.K., Horton M. The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. J Cell Sci. 108:1995;2729-2732.
15. Nakamura I., Takahashi N., Sasaki T., Jimi E., Kurokawa T., Suda T. Chemical and physical properties of the extracellular matrix are required for the actin ring formation in osteoclasts. J Bone Miner Res. 11:1996;1873-1879.
16. Suzuki H., Nakamura I., Takahashi N., Ikuhara T., Matsuzaki K., Isogai Y., Hori M., Suda T. Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Endocrinology. 137:1996;4685-4690.
17. Murakami H., Takahashi N., Sasaki T., Udagawa N., Tanaka S., Nakamura I., Zhang D., Barbier A., Suda T. A possible mechanism of the specific action of bisphosphonates on osteoclasts tiludronate preferentially affects polarized osteoclasts having ruffled borders . Bone. 17:1995;137-144.
18. Suda T., Nakamura I., Jimi E., Takahashi N. Regulation of osteoclast function. J Bone Miner Res. 12:1997;869-879.
19. Burgess T.L., Qian Y., Kaufman S., Ring B.D., Van G., Capparelli C., Kelley M., Hsu H., Boyle W.J., Dunstan C.R., Hu S., Lacey D.L. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol. 145:1999;527-538.
20. Fleisch H. Bisphosphonates mechanisms of action . Endocr Rev. 19:1998;80-100.
21. Russell R.G., Rogers M.J. Bisphosphonates from the laboratory to the clinic and back again . Bone. 25:1999;97-106.
22. Sato M., Grasser W., Endo N., Akins R., Simmons H., Thompson D.D., Golub E., Rodan G.A. Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest. 88:1991;2095-2105.
23. Watanabe J., Amizuka N., Noda T., Ozawa H. Cytochemical and ultrastructural examination of apoptotic odontoclasts induced by bisphosphonate administration. Cell Tissue Res. 301:2000;375-387.
24. Hughes D.E., Wright K.R., Uy H.L., Sasaki A., Yoneda T., Roodman G.D., Mundy G.R., Boyce B.F. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res. 10:1995;1478-1487.
25. +-ATPase in osteoclasts and its role in resorption. Cell Tissue Res. 278:1994;265-271.
26. Inoue M., Yoshida H., Akisaka T. Visualization of acidic compartments in cultured osteoclasts by use of an acidotrophic amine as a marker for low pH. Cell Tissue Res. 298:1999;527-537.
27. +-ATPase. J Exp Biol. 203:2000;127-135.
28. Futai M., Oka T., Sun-Wada G., Moriyama Y., Kanazawa H., Wada Y. Luminal acidification of diverse organelles by V-ATPase in animal cells. J Exp Biol. 203:2000;107-116.
29. Scimeca J.C., Franchi A., Trojani C., Parrinello H., Grosgeorge J., Robert C., Jaillon O., Poirier C., Gaudray P., Carle G.F. The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants. Bone. 26:2000;207-213.
30. +-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation. J Biol Chem. 275:2000;8760-8765.
31. Nakamura I., Takahashi N., Udagawa N., Moriyama Y., Kurokawa T., Jimi E., Sasaki T., Suda T. Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice. FEBS Lett. 401:1997;207-212.
32. 3 in osteoclast differentiation and function. Methods Enzymol. 282:1997;223-235.
33. Luckman S.P., Hughes D.E., Coxon F.P., Graham R., Russell G., Rogers M.J. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res. 13:1998;581-589.
34. Fisher J.E., Rogers M.J., Halasy J.M., Luckman S.P., Hughes D.E., Masarachia P.J., Wesolowski G., Russell R.G., Rodan G.A., Reszka A.A. Alendronate mechanism of action geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro . Proc Natl Acad Sci USA. 96:1999;133-138.
35. Fisher J.E., Rodan G.A., Reszka A.A. In vivo effects of bisphosphonates on the osteoclast mevalonate pathway. Endocrinology. 141:2000;4793-4796.
36. Coxon F.P., Helfrich M.H., Van't Hof R., Sebti S., Ralston S.H., Hamilton A., Rogers M.J. Protein geranylgeranylation is required for osteoclast formation, function, and survival inhibition by bisphosphonates and GGTI-298 . J Bone Miner Res. 15:2000;1467-1476.
37. Sasaki T. Recent advances in the ultrastructural assessment of osteoclastic resorptive functions. Microsc Res Tech. 33:1996;182-191.
38. Li Y.P., Chen W., Liang Y., Li E., Stashenko P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 23:1999;447-451.
39. +-ATPase cause infantile malignant osteopetrosis. Hum Mol Genet. 9:2000;2059-2063.
40. +-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis. Bone. 30:2002;436-439.
41. Ito M., Amizuka N., Nakajima T., Ozawa H. Bisphosphonate acts on osteoclasts independent of ruffled borders in osteosclerotic (oc/oc) mice. Bone. 28:2001;609-616.
42. Halasy-Nagy J.M., Rodan G.A., Reszka A.A. Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis. Bone. 29:2001;553-559.
43. +-ATPase and microfilaments during osteoclast activation. J Biol Chem. 274:1999;29164-29171.
44. +-ATPase contains a filamentous actin binding site. J Biol Chem. 275:2000;32331-32337.
45. +-ATPase trigger apoptotic cell death of osteoclasts. J Bone Miner Res. 12:1997;1116-1123.
46. Silver I.A., Murrills R.J., Etherington D.J.I. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res. 175:1988;266-276.