The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor pravastatin reduces disease activity and inflammation in dextran-sulfate induced colitis

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 1, 2003, Pages 78-85

  Sasaki, Makoto ^a   Bharwani, Sulaiman ^a   Jordan, Paul ^a   Joh, Takashi ^b   Manas, Kenneth ^a   Warren, April ^a   Harada, Hirohisa ^a   Carter, Patsy ^a   Elrod, John W ^a   Wolcott, Michael ^a   Grisham, Matthew B ^a   Alexander, J Steven ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DEXTRAN SULFATE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; NITRIC OXIDE SYNTHASE; PRAVASTATIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CACHEXIA; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; COLITIS; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG POTENCY; ENTERITIS; HISTOPATHOLOGY; INTESTINE EPITHELIUM; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; LEUKOCYTE ADHERENCE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYMPTOMATOLOGY;

ANIMALS; CELL ADHESION MOLECULES; CELL MEMBRANE PERMEABILITY; CHOLESTEROL; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPITHELIAL CELLS; GENE EXPRESSION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOPROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PRAVASTATIN; RNA, MESSENGER;

EID: 0037382469     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.044099     Document Type: Article

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