iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 275, Issue 3 38-3, 1998, Pages

  Binion, David G ^a   Fu, Sidong ^b   Ramanujam, Kalathur S ^b   Chai, Yuh Cherng ^c   Dweik, Raed A ^c   Drazba, Judith A ^c   Wade, Justin G ^a   Ziats, Nicholas P ^d   Erzurum, Serpil C ^c   Wilson, Keith T ^b  

^a FROEDTERT MEMORIAL LUTHERAN HOSPITAL   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Endothelium; Inflammatory bowel disease; Intestinal mucosa; Vascular; Vascular cell adhesion molecule 1

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE; LYSINE DERIVATIVE; N IMINOETHYLLYSINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENTERITIS; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

EID: 0031659995     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.275.3.g592     Document Type: Article

References (53)

1. Ades, E. W., F. J. Candal, R. A. Swerlick, V. G. George, S. Summers, D. C. Bosse, and T. J. Lawley. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Invest. Dermatol. 99: 683-690, 1992.
2. Arndt, H., J. B. Russell, I. Kurose, P. Kubes, and D. N. Granger. Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Gastroenterology 105: 675-680, 1993.
3. Binion, D. G., Y. C. Chai, J. A. Drazba, J. G. Wade, and K. T. Wilson. Vitamin E pretreatment of human intestinal microvascular endothelial cells (HIMEC) inhibits leukocyte adhesion: a therapeutic role for antioxidants in intestinal inflammation? (Abstract). Gastroenterology 114: A933, 1998.
4. Binion, D. G., S. Kugathasan, C. J. Wilbur, G. A. West, K. A. Miller, N. P. Ziats, A. D. Levine, and C. Fiocchi. Differential production of chemokines MCP-1 and IL-8 between human intestinal microvascular (HIMEC) and large vessel endothelial cells (Abstract). Gastroenterology 112: A936, 1997.
5. Binion, D. G., D. E. Orosz, S. Kugathasan, K. A. Miller, S. Fu, K. T. Wilson, N. P. Ziats, S. E. Emancipator, J. W. Jacobberger, G. T. Keusch, and C. Fiocchi. Generation and characterization of immortalized human intestinal microvascular endothelial cell lines (HIMEC-CMVT) (Abstract). Gastroenterology 112: A936, 1997.
6. Binion, D. G., G. A. West, K. Ina, N. P. Ziats, S. N. Emancipator, and C. Fiocchi. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 112: 1895-1907, 1997.
7. Bonmann, E., C. Suschek, M. Spranger, and V. Kolb-Bachofen. The dominant role of exogenous or endogenous interleukin-1β on expression and activity of inducible nitric oxide synthase in rat microvascular brain endothelial cells. Neurosci. Lett. 230: 109-112, 1997.
8. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
9. Buttery, L. D., T. J. Evans, D. R. Springall, A. Carpenter, J. Cohen, and J. M. Polak. Immunochemical localization of inducible nitric oxide synthase in endotoxin-treated rats. Lab. Invest. 71: 755-764, 1994.
10. Darley-Usmar, V., and R. White. Disruption of vascular signaling by the reaction of nitric oxide with superoxide: implications for cardiovascular disease. Exp. Physiol. 82: 305-316, 1997.
11. DeCaterina, R., P. Libby, H. B. Peng, V. J. Thannickal, T. B. Rajavashisth, J. M. A. Gimbrone, W. S. Shin, and J. K. Liao. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J. Clin. Invest. 96: 60-68, 1995.
12. DiCorleto, P. E., and C. A. de la Motte. Characterization of the adhesion of the human monocytic cell line U-937 to cultured endothelial cells. J. Clin. Invest. 75: 1153-1161, 1985.
13. Faruqi, R., C. de la Motte, and P. E. DiCorleto. α-Tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J. Clin. Invest. 94: 592-600, 1994.
14. Fukahori, M., K. Ichimori, H. Ishida, H. Nakagawa, and H. Okino. Nitric oxide reversibly suppresses xanthine oxidase activity. Free Radic. Res. 21: 203-212, 1994.
15. Furchgott, R. F., and P. M. Vanhoutte. Endothelium-derived relaxing and contracting factors. FASEB J. 3: 2007-2018, 1989.
16. Granger, D. N., and P. Kubes. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J. Leukoc. Biol. 55: 662-675, 1994.
17. Grisham, M. B. Interaction between nitric oxide and superoxide: role in modulating leukocyte adhesion in the postischemic microvasculature. Transplant. Proc. 27: 2842-2843, 1995.
18. Grisham, M. B. Oxidants and free radicals in inflammatory bowel disease. Lancet 344: 859-861, 1994.
19. Gross, S. S., E. A. Jaffe, R. Levi, and R. G. Kilbourn. Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. Biochem. Biophys. Res. Commun. 178: 823-829, 1991.
20. Hickey, M. J., K. A. Sharkey, E. G. Sihota, P. H. Reinhardt, J. D. Macmicking, C. Nathan, and P. Kubes. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J. 11: 955-964, 1997.
21. Hogaboam, C. M., K. Jacobson, S. M. Collins, and M. G. Blennerhassett. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G673-G684, 1995.
22. Janssens, S. P., A. Shimouchi, T. Quertermous, D. B. Bloch, and K. D. Bloch. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J. Biol. Chem. 267: 14519-14522, 1992.
23. Kaku, Y., H. Nanri, T. Sakimura, K. Ejima, A. Kuroiwa, and M. Ikeda. Differential induction of constitutive and inducible nitric oxide synthases by distinct inflammatory stimuli in bovine aortic endothelial cells. Biochim. Biophys. Acta 1356: 43-52, 1997.
24. Kubes, P., and D. N. Granger. Nitric oxide modulates microvascular permeability. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H611-H615, 1992.
25. Kubes, P., M. Suzuki, and D. N. Granger. Nitric oxide - an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88: 4651-4655, 1991.
26. Kurose, I., R. Wolf, M. B. Grisham, T. Y. Aw, R. D. Specian, and D. N. Granger. Microvascular responses to inhibition of nitric oxide production. Circ. Res. 76: 30-39, 1995.
27. Lowenstein, C. J., C. S. Glatt, D. S. Bredt, and S. H. Snyder. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89: 6711-6715, 1992.
28. Marks, R. M., M. Czerniecki, and R. Penny. Human dermal microvascular endothelial cells: an improved method for tissue culture and a description of some singular properties in culture. In Vitro Cell. Dev. Biol. 21: 627-635, 1985.
29. McCafferty, D. M., J. S. Mudgett, M. G. Swain, and P. Kubes. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 112: 1022-1027, 1997.
30. McKinney, J. S., K. A. Willoughby, S. Liang, and E. F. Ellis. Stretch-induced injury of cultured neuronal, glial, and endothelial cells. Effect of polyethylene glycol-conjugated superoxide dismutase. Stroke 27: 934-940, 1996.
31. Miles, A. M., D. S. Bohle, P. A. Glassbrenner, B. Hansert, D. A. Wink, and M. B. Grisham. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide J. Biol. Chem. 271: 40-47, 1996.
32. Miller, M. J., H. Sadowska-Krowicka, S. Chotinaruemol, J. L. Kakkis, and D. A. Clark. Amelioration of chronic ileitis by nitric oxide synthase inhibition. J. Pharmacol. Exp. Ther. 2664-11-16, 1993.
33. Miller, M. J. S., J. H. Thompson, X.-J. Zhang, H. Sadowskakrowicka, J. L. Kakkis, U. K. Munshi, M. Sandoval, J. L. Rossi, S. Elobychildress, J. S. Beckman, Y. Z. Ye, C. P. Rodi, P. T. Manning, M. G. Currie, and D. A. Clark. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109: 1475-1483, 1995.
34. Moore, W. M., R. K. Webber, K. F. Fok, G. M. Jerome, C. M. Kornmeier, F. S. Tjoeng, and M. G. Currie. Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element. Bioorg. Med. Chem. 4: 1559-1564, 1996.
35. Niu, X. F., C. W. Smith, and P. Kubes. Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ. Res. 74: 1133-1140, 1994.
36. Pober, J. S., and R. S. Cotran. The role of endothelial cells in inflammation. Transplantation 50: 537-544, 1990.
37. Pou, S., W. S. Pou, D. S. Bredt, S. H. Snyder, and G. M. Rosen. Generation of superoxide by purified brain nitric oxide synthase. J. Biol. Chem. 267: 24173-24176, 1992.
38. Rachmeliwitz, D., J. S. Stamler, F. Karmeli, M. E. Mullins, D. J. Singel, J. Loscalzo, R. J. Xavier, and D. K. Podolsky. Peroxynitrite-induced rat colitis - a new model of colonic inflammation. Gastroenterology 105: 1681-1688, 1993.
39. Radi, R., J. S. Beckman, K. M. Bush, and B. A. Freeman. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys. 288: 481-487, 1991.
40. Rosenkranz-Weiss, P., W. C. Sessa, S. Milstien, S. Kaufman, C. A. Watson, and J. S. Pober. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J. Clin. Invest. 93: 2236-2243, 1994.
41. Rubbo, H., V. Darley-Usmar, and B. A. Freeman. Nitric oxide regulation of tissue free radical injury. Chem. Res. Toxicol. 9: 809-820, 1996.
42. Schini-Kerth, V., A. Bara, A. Mulsch, and R. Busse. Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur. J. Pharmacol. 265: 83-87, 1994.
43. Shears, L. J., N. Kawaharada, E. Tzeng, T. R. Billiar, S. C. Watkins, I. Kovesdi, A. Lizonova, and S. M. Pham. Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis. J. Clin. Invest. 100: 2035-2042, 1997.
44. Sherman, P. A., V. E. Laubach, B. R. Reep, and E. R. Wood. Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry 32: 11600-11605, 1993.
45. Shibutani, T., T.M. Johnson, Z.X. Yu, V.J. Ferrans, J. Moss, and S. E. Epstein. Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by Cytomegalovirus infection of smooth muscle cells. J. Clin. Invest. 100: 2054-2061, 1997.
46. Singer, I. I., D. W. Kawaka, S. Scott, J. R. Weidner, R. A. Mumford, T. E. Riehl, and W. F. Stenson. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 111: 871-875, 1996.
47. 2 for platelet-derived growth factor signal transduction. Science 270: 13585-13588, 1995.
48. Suzuki, M., M. B. Grisham, and D. N. Granger. Leukocyte-endothelial cell adhesive interactions: role of xanthine oxidase-derived oxidants. J. Leukoc. Biol. 50: 488-494, 1991.
49. Varilek, G. W., F. Yang, K. S. Ramanujam, W. J. S. de Villiers, and K. T. Wilson. Inducible nitric oxide synthase activity is protective in the enterocolitis of IL-10 knock-out mice (Abstract). Gastroenterology 114: A1107, 1998.
50. Wilson, K. T., R. F. Musselman, L. E. Mahdi, and R. T. Jones. Immunohistochemical detection of inducible nitric oxide synthase in Helicobacter pylori gastritis (Abstract). Gastroenterology 108: A942, 1995.
51. Wilson, K. T., K. S. Ramanujam, H. L. Mobley, R. F. Musselman, S. P. James, and S. J. Meltzer. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology 111: 1524-1533, 1996.
52. Wink, D. A., I. Hanbauer, M. C. Krishna, W. DeGraff, J. Gamson, and J. B. Mitchell. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc. Natl. Acad. Sci. USA 90: 9813-9817, 1993.
53. Xie, Q. W, H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256: 225-228, 1992.