Correlation study showing no concordance between EPAS-1/HIF-2α mRNA and protein expression in transitional cell cancer of the bladder

Urology

Volumn 61, Issue 4, 2003, Pages 851-857

  Ji, Pingguang ^b   Xuan, Jim W ^a   Onita, Toru ^b   Sakai, Hideki ^b   Kanetake, Hiroshi ^b   Gabril, Manal Y ^b   Sun, Yunming ^b   Moussa, Madeleine ^b   Chin, Joseph L ^b  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; COMPLEMENTARY DNA; ENDOTHELIAL PER ARNT SIM DOMAIN PROTEIN 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER PATIENT; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTECTOMY; DENSITY; DNA PROBE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; NECROSIS; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSITIONAL CELL CARCINOMA; TRANSURETHRAL RESECTION;

EID: 0037381261     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-4295(02)02405-6     Document Type: Article

References (16)

1. Tian H., McKnight S.L., Russell D.W. Endothelial PAS domain protein 1 (EPAS-1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11:1997;72-82.
2. Peng J., Zhang L., Drysdale L., et al. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci USA. 97:2000;8386-8391.
3. Wiesener M.S., Turley H., Allen W.E., et al. Induction of endothelial PAS domain protein-1 by hypoxia characterization and comparison with hypoxia-inducible factor-1alpha. Blood. 92:1998;2260-2268.
4. Jain S., Maltepe E., Lu M.M., et al. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev. 73:1998;117-123.
5. Blancher C., Harris A.L. The molecular basis of the hypoxia response pathway tumour hypoxia as a therapy target. Cancer Metastasis Rev. 17:1998;187-194.
6. Richard D.E., Berra E., Pouyssegur J. Angiogenesis how a tumor adapts to hypoxia. Biochem Biophys Res Commun. 266:1999;718-722.
7. Maxwell P.H., Dachs G.U., Gleadle J.M., et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA. 94:1997;8104-8109.
8. Talks K.L., Turley H., Gatter K.C., et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 157:2000;411-421.
9. Onita T., Ji P.G., Xuan J.W., et al. Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. Clin Cancer Res. 8:2002;471-480.
10. 2 tension. Proc Natl Acad Sci USA. 92:1995;5510-5514.
11. Huang L.E., Arany Z., Livingston D.M., et al. Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its alpha subunit. J Biol Chem. 271:1996;32253-32259.
12. Wenger R.H., Rolfs A., Marti H.H., et al. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun. 223:1996;54-61.
13. Yuan Y., Beitner-Johnson D., Millhorn D.E. Hypoxia-inducible factor 2alpha binds to cobalt in vitro. Biochem Biophys Res Commun. 288:2001;849-854.
14. Huang L.E., Gu J., Schau M., et al. Regulation of hypoxia-inducible factor 1 alpha is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA. 95:1998;7987-7992.
15. Carmeliet P., Dor Y., Herbert J.M., et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:1998;485-490.
16. Dachs G.U., Patterson A.V., Firth J.D., et al. Targeting gene expression to hypoxic tumor cells. Nat Med. 3:1997;515-520.