Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential

Cancer

Volumn 77, Issue 8 SUPPL., 1996, Pages 1736-1740

  Konno, Hiroyuki ^a   Tanaka, Tatsuo ^a   Kanai, Toshikazu ^a   Maruyama, Keiji ^a   Nakamura, Satoshi ^a   Baba, Shozo ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

angiogenesis; colorectal cancer; DCC; doubling time; hepatic metastases; K ras; orthotopical transplantation; p53; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; FUMAGILLOL CHLOROACETYLCARBAMATE; MESSENGER RNA; PROTEIN P53;

ANIMAL MODEL; ANIMAL TISSUE; CANCER TRANSPLANTATION; COLORECTAL CANCER; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BODY WEIGHT; CELL CYCLE; CELL DIVISION; COLORECTAL NEOPLASMS; CYCLOHEXANES; GENES, P53; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MUTATION; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; SESQUITERPENES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0029964403     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19960415)77:8<1736::AID-CNCR48>3.0.CO;2-Y     Document Type: Conference Paper

References (23)

1. Hamilton SR. Molecular genetic alternation as potential prognostic indicators in colorectal carcinoma. Cancer 1992;69:1589-91.
2. Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, Tribolet N, Cavenee WK. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature Genetics 1994;8:171-6.
3. Kieser A, Weich HA, Brandner G, Marme D, Kolch W. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 1994;9:963-9.
4. Dameron KM, Volpert OV, Tainsky MA, Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994;265:1582-4.
5. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Bern H, et al. Synthetic analogs of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 1990;348:555-7.
6. Kusaka M, Sudo K, Fujita T, Marui S, Itoh S, Ingber D, et al. Potent anti-angiogenic action of AGM-1470: Comparison to the fumagillin parent. Biochem Biophys Res Commun 1991;174:1070-6.
7. Yamaoka M, Yamamoto T, Ikeyama S, Sudo K, Fujita T. Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Cancer Res 1993;53:5233-6.
8. Yamaoka M, Yamamoto T, Masaki T, Ikeyama S, Sudo K, Fujita T. Inhibition of tumor growth and metastasis of rodent tumor by the angiogenesis inhibitor 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470). Cancer Res 1993;53:4262-7.
9. Yanase T, Tamura M, Fujita K, Kodama S, Tanaka K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993;53:2566-70.
10. Konno H, Tanaka T, Matsuda I, Kanai T, Maruo Y, Nishino N, et al. Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and hepatic metastases of human colon cancer. Int J Cancer 1995;61:268-71.
11. Tanaka T, Konno H, Matsuda I, Nakamura S, Baba S. Prevention of hepatic metastasis of human colon cancer by angiogenesis. Cancer Res 1995;55:836-9.
12. Itoh F, Hinoda Y, One M, Ohe Y, Ban T, Endo T, et al. Decreased expression of DCC mRNA in human colorectal cancers. Int J Cancer 1993;53:260-3.
13. Igarashi H, Sugimura H, Maruyama K, Kitayama Y, Ohta I, Suzuki M, et al. Alteration of immunoreactivity by hydrated autoclaving, microwave treatment, and simple heating of paraffin-embedded tissue sections. APMIS 1994;102:295-307.
14. Morikawa K, Walker S, Nakajima M, Pathak S, Jessup JM, Filder IJ. Influence of organ environment on the growth, selection and metastasis of human colon carcinoma cells in nude mice. Cancer Res 1988;48:6863-71.
15. Fu X, Besterman JM, Monosov A, Hoffman RM. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci USA 1991;88:9345-9.
16. Furukawa T, Kubota T, Watanabe M, Kitajima M, Hoffman RM. Orthotopic transplantation of histologically intact clinical specimens of stomach cancer to nude mice: correlation of metastatic sites in mouse and individual patient donors. Int J Cancer 1993;53:608-12.
17. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
18. Volkmann M, Hofmann WJ, Muller M, Rath U, Otto G. Zentgraf H. et al. p53 overexpression is frequent in European hepatocellular carcinoma and largely independent of the codon 249 hot spot mutation. Oncogene 1994;9:195-204.
19. Liotta LA, Rao CN, Wewer UM. Biochemical interactions with the basement membranes. Ann Rev Biochem 1986;55:1037-57.
20. Folkman J. The vascularization of tumors. Sci Am 1976; 234:59-73.
21. Folkman J. What is evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6.
22. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-44.
23. Denekamp J. Vasculature as a target for tumor therapy. Prog Appl Microcirc 1984;4:28-38.