Inhibitory effects of the antiangiogenic agent TNP-470 on establishment and growth of hematogenous metastasis of human pancreatic carcinoma in SCID beige mice in vivo

Pancreas

Volumn 15, Issue 3, 1997, Pages 251-257

  Kawarada, You ^a   Ishikura, Hiroshi ^b   Kishimoto, Takashi ^b   Saito, Katsunori ^a   Takahashi, Toshiyuki ^b   Kato, Hiroyuki ^b   Yoshiki, Takashi ^a  

^a Department of Pathology ^*  (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Hepatic metastasis; Pancreatic carcinoma; SClD beige mouse; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; CYCLINE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; FUMAGILLOL CHLOROACETYLCARBAMATE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; LIVER METASTASIS; MALE; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; SCID MOUSE; SUBCUTANEOUS DRUG ADMINISTRATION; UMBILICAL VEIN;

EID: 0030781206     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199710000-00006     Document Type: Article

References (18)

1. Folkman J. Tumor angiogenesis. Adv Cancer Res 1985;43:175203.
2. Ingber D, Fujita T, Kishimoto S, et al. Synthetic analogues of fumagiliin that inhibit angiogenesis and suppress tumor growth. Nature 1990:348:555-7.
3. Yamaoka M, Yamamoto T, Ikeyama S, Sudo K, Fujita T. Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Cancer Res 1993;53:5233-6.
4. Yanase T, Masaki T, Fujita K, Kodama S, Tanaka K. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 1993;53:2566-70.
5. Tanaka T, Konno H, Matsuda I, Nakamura S, Baba S. Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470. Cancer Res I995;55:836-9.
6. Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastasis: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med 1995;l:149-53.
7. Yamaoka M, Yamamoto T, Masaki T, Ikeyama S, Sudo K, Fujita T. Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbomonyl)fumagillol (TNP-470; AGM-1470). Cancer Res 1993;53:4262-7.
8. Tsujimoto H, Hagiwara A, Osaki K, et al. Therapeutic effects of the angiogenesis inhibitor TNP-470 against carcinomatous peritonitis in mice. Anti-Cancer Drugs 1995;6:438 t2.
9. Takahashi T, Ishikura H, Iwai K, et al. Cytokine regulation of cell-to-cell interactions in LAK cell cytotoxicity in vitro. Cancer Immunol Jmmiinother 1993;36:76-82.
10. Iwai K, Ishikura H, Kaji M, et al. Importance of E-selectin (ELAM-1) and sialyl Lewis3 in the adhesion of pancreatic carcinoma cells to activated endothelium. Int J Cancer 1993;54: 972-7.
11. Sugiura H, Ishikura H, Omi M, et al. Lymphokine-activated killer cytotoxicity against pancreas adenocarcinoma cell lines and vascular endothelial cells. Pailiol Int 1994;44:688-96.
12. Kishimoto T, Ishikura H, Kimura C, Takahashi T, Kato H, Yoshiki T. Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis3 antigen. Int J Cancer Pred Oncot 1996;69:290-4.
13. Enzmann H, Edler L, Bannasch P. Simple elementary method for the quantification of focal liver lesions induced by carcinogens. Carcinogenesis 1987:8:231-5.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;! 19:493-501.
15. Kusaka M, Sudo K, Matsutani E, et al. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br] Cancer 1994;69:212-6.
16. Yamamoto T, Sudo K, Fujita T. Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470). Anticancer Res 1994;14:l^t.
17. Abe J, Zhou W, Takuwa N, et al. A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Res 1994;54:340712.
18. Folkman J. Angiogenesis in cancer, vascular rheumatoid and other disease. Nature Med 1995;1:27-31.