CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice

Atherosclerosis

Volumn 167, Issue 1, 2003, Pages 25-32

  Kuziel, William A ^a   Dawson, Tracey C ^b   Quinones, Marlon ^c   Garavito, Edgar ^c   Chenaux, George ^c   Ahuja, Seema S ^c   Reddick, Robert L ^c   Maeda, Nobuyo ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Atherosclerosis; Chemokine receptors; Inflammation; Knockout mice; Macrophages

Indexed keywords

APOLIPOPROTEIN E; CHEMOKINE RECEPTOR CCR5; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY LESION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; B LYMPHOCYTE; CONTROLLED STUDY; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; KNOCKOUT GENE; KNOCKOUT MOUSE; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RIBONUCLEASE PROTECTION ASSAY; RNA ISOLATION; T LYMPHOCYTE;

ANALYSIS OF VARIANCE; ANIMALS; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; BLOTTING, NORTHERN; CHEMOKINE CCL2; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICE, KNOCKOUT; PROBABILITY; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RNA; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 0037371464     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(02)00382-9     Document Type: Article

References (29)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
2. Ross R. Atherosclerosis-an inflammatory disease. New Engl. J. Med. 340:1999;115-126.
3. Reape T.J., Groot P.H. Chemokines and atherosclerosis. Atherosclerosis. 147:1999;213-235.
4. Glass C.K., Witztum J.L. Atherosclerosis: the road ahead. Cell. 104:2001;503-516.
5. Nie Q., Fan J., Haraoka S., Shimokama T., Watanabe T. Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies in hypercholesterolemic rats: implications of the ICAM-1 and LFA-1 pathway in atherogenesis. Lab. Invest. 77:1997;469-482.
6. Nageh M.F., Sandberg E.T., Marotti K.R., Lin A.H., Melchior E.P., Bullard D.C., Beaudet A.L. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 17:1997;1517-1520.
7. Gu L., Okada Y., Clinton S.K., Gerard C., Sukhova G.K., Libby P., Rollins B.J. Absence of monocyte chemoattractant protein 1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell. 2:1998;275-281.
8. Boring L., Gosling J., Cleary M., Charo I.F. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 394:1998;894-897.
9. Dawson T.C., Kuziel W.A., Osahar T.A., Madea N. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis. 143:1999;205-211.
10. Boisvert W.A., Santiago R., Curtiss L.K., Terkeltaub R.A. A leukocyte homologue of the IL-8 receptor CXCR2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J. Clin. Invest. 101:1998;353-363.
11. Rottman J.B., Ganley K.P., Williams K., Wu L., Mackay C.R., Ringler D.J. Cellular localization of the chemokine receptor CCR5. Am. J. Pathol. 151:1997;1341-1351.
12. Mack M., Cihak J., Simonis D., Luckow B., Proudfoot A.E.I., Plachy J., Bruhl H., Frink F., Anders H., Veilhauer V., Pfirstinger J., Stangassinger M., Schlondorff D. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J. Immunol. 166:2001;4697-4704.
13. Berger O., Gan X., Gujuluva C., Burns A.R., Sulur G., Stins M., Way D., Witte M., Weinand M., Said J., Kim K.S., Taub D., Graves M.C., Fiala M. CXC and CC chemokine receptors on coronary and brain endothelia. Mol. Med. 5:1999;795-805.
14. Schecter A.D., Calderon T.M., Berman A.B., McManus C.M., Fallon J.T., Rossikhina M., Zhou W., Christ G., Berman J.W., Taubman M.B. Human vascular smooth muscle cells possess functional CCR5. J. Biol. Chem. 275:2000;5466-5471.
15. Wilcox J.N., Nelken N.A., Coughlin S.R., Gordon D., Schall T.J. Local expression of inflammatory cytokines in human atherosclerotic plaques. J. Atheroscler. Thromb. 1:(Suppl. 1):1994;S10-S13.
16. Gonzalez P., Alvarez R., Batalla A., Reguero J.R., Alvarez V., Astudillo A., Cubero G.I., Cortina A., Coto E. Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction. Genes Immunity. 2:2001;191-195.
17. Szalai C., Duba J., Prohaszka Z., Kalina A., Szabo T., Nagy B., Horvath L., Csaszar A. Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Atherosclerosis. 158:2001;233-239.
18. Zhang S.H., Reddick R.L., Piedrahita J.A., Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 258:1992;468-471.
19. Kuziel W.A., Morgan S.J., Dawson T.C., Griffin S., Smithies O., Ley K., Maeda N. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. USA. 94:1997;12053-12058.
20. Paigen B., Morrow A., Holmes P.A., Mitchell D., Williams R.A. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 68:1987;231-240.
21. Plump A.S., Smith J.D., Hayek T., Aalto-Setala K., Walsh A., Verstuyft J.G., Rubin E.M., Breslow J.L. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 71:1992;343-353.
22. Reddick R.L., Zhang S.H., Maeda N. Atherosclerosis in mice lacking Apo E: evaluation of lesional development and progression. Arterioscler. Thromb. Vasc. Biol. 14:1994;141-147.
23. Huffnagle G.B., McNeil L.K., McDonald R.A., Murphy J.W., Toews G.B., Maeda N., Kuziel W.A. Cutting edge: role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J. Immunol. 163:1999;4642-4646.
24. Sato N., Kuziel W.A., Melby P.C., Reddick R.L., Kostechi V., Zhao W., Maeda N., Ahuja S.K., Ahuja S.S. Innate defects in the generation of IFN-γ are overcome to control infection with Leishmania donovani in C-C chemokine receptor 5-macrophage inflammatory protein-1α, or C-C chemokine receptor 2-deficient mice. J. Immunol. 163:1999;5519-5525.
25. Glass W.G., Liu M.T., Kuziel W.A., Lane T.E. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology. 288:2001;8-17.
26. Zhou Y., Kurihara T., Ryseck R.P., Yang Y., Ryan C., Loy J., Warr G., Bravo R. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J. Immunol. 160:1998;4018-4025.
27. Dansky H.M., Charlton S.A., Harper M.M., Smith J.D. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc. Natl. Acad. Sci. USA. 94:1997;4642-4646.
28. Daugherty A., Pure E., Delfel-Butteiger D., Chen S., Leferovich J., Roselaar S.E., Rader D.J. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J. Clin. Invest. 100:1997;1575-1579.
29. Johnson J.L., Jackson C.L. Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse. Atherosclerosis. 154:2001;399-406.