The kappa opioid receptor is associated with the perception of visceral pain

Gut

Volumn 43, Issue 3, 1998, Pages 312-313

  Black, D ^a   Trevethick, M ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; RECEPTOR SUBTYPE;

ABDOMINAL PAIN; ANALGESIA; ANIMAL EXPERIMENT; DRUG RECEPTOR BINDING; GASTROINTESTINAL DISEASE; GENE TARGETING; MOUSE; NOCICEPTION; NONHUMAN; NOTE; PAIN; PRIORITY JOURNAL; VISCERAL PAIN;

EID: 0031696394     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.43.3.312     Document Type: Note

References (8)

1. Dhawan BN, Cesselin F, Raghubir R, et al. International union of pharmacology. XII. Classification of opioid receptors. Pharmacol Rev 1996;48:567-92.
2. Rubinstein M, Mogil JF, Japon M, et al. Absence of opioid stress-induced analgesia in mice lacking β-endorphin by site-directed mutagenesis. Proc Natl Acad Sci USA 1996;93:3995-4000.
3. Konig M, Zimmer AM, Steiner H, et al. Pain responses, anxiety and aggression in mice deficient in pre-pro-enkephalin. Nature 1996;383:535-8.
4. Mattes HW, Maldonado R, Simonin F, et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid receptor. Nature 1996;383:819-23.
5. Zhu Y, King M, Schuller E, et al. Genetic disruption of the mouse δ-opioid receptor gene. Soc Neurosci Abs 1997;23:584.
6. Camilleri M, Chio M-G. Review Article: irritable bowel syndrome. Aliment Pharmcol Ther 1997;11:3-15.
7. Houghton LA, Whorwell PJ. Opening the doors of perception in the irritable bowel syndrome. Gut 1997;41:567-8.
8. Sengupta JN, Su X, Gebhart GF. κ but not μ or δ opioids attenuate responses to distension of afferent fibres innervating the rat colon. Gastroenterology 1996;111:968-80.