Effects of kappa-opioid receptor agonists on responses to colorectal distension in rats with and without acute colonic inflammation

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 707-715

  Burton, Maureen B ^a,b   Gebhart, G F ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (3,4 DICHLORO N METHYLPHENYLACETAMIDO) 2 (1 PYRROLIDINYL)ETHYL]PHENOXYACETIC ACID; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ACETIC ACID; ASIMADOLINE; ENADOLINE; KAPPA OPIATE RECEPTOR AGONIST; MORPHINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; NORBINALTORPHIMINE; SODIUM CHLORIDE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; COLITIS; COLON DILATATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; ELECTROMYOGRAM; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; VISCERAL PAIN;

ACUTE DISEASE; ANALGESICS, OPIOID; ANIMALS; COLITIS; COLON; ELECTROMYOGRAPHY; MALE; NALOXONE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; RECTUM;

EID: 0031836946     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Andreev N, Urban L and Dray A (1994) Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation. Neuroscience 58:793-798.
2. Antonijevic I, Mousa SA, Schafer M and Stein C (1995) Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci 15:165-172.
3. Bagnol D, Mansour A, Akil H and Watson SJ (1997) Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience 81:579-591.
4. Borgbjerg FM, Frigast C, Madsen JB and Mikkelsen LF (1996) The effect of intrathecal opioid receptor agonists on visceral noxious stimulation in rabbits. Castroenterology 110:139-146.
5. Burton MB and Gebhart GF (1995a) K-Opioid receptor agonists attenuate responses to colorectal distension in rats with normal or inflamed colons. Neurosci Abs 21:1170.
6. Burton MB and Gebhart GF (1995b) Effects of intracolonic acetic acid on responses to colorectal distension in the rat. Brain Res 672:77-82.
7. Butelman ER, Negus SS, Ai Y, de Costa BR and Woods JH (1993) Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys. J Pharm Exp Ther 267:1269-1276.
8. Chang A-C, Takemori AE, Ojala WH, Gleason WB and Portoghese PS (1994) κ opioid receptor selective affinity labels: Electrophilic benzacetamides as κ-selective opioid antagonists. J Med Chem 37:4490-4498.
9. 3 subtype. J Pharm Exp Ther 251:461-468.
10. Danzebrink RM and Gebhart GF (1990) Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception. J Pharmacol Exp Ther 253:698-705.
11. Danzebrink RM, Green SA and Gebhart GF (1995) Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat. Pain 63:39-47.
12. Diop L, Riviere PJM, Pascaud X and Junien J-L (1994a) Peripheral κ-opioid receptors mediate the antinociceptive effect of fetodizine on the duodenal pain reflex in the rat. Eur J Pharmacol 271:65-71.
13. Diop L, Riviere PJM, Pascaud X, Dassaud M and Junien J-L (1994b) Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonie pain reflex. Eur J Pharmacol 257:181-187.
14. Dong X-W, Parsons CG and Headley PM (1991) Effects of intravenous μ and κ opioid receptor agonists on sensory responses of convergent neurons in the dorsal horn of spinalized rats. Br J Pharmacol 103:1230-1236.
15. Fretland EJ, Djuric SW and Gaginella TS (1990) Eicosanoids and inflammatory bowel disease: Regulation and prospects for therapy. Prostagfandins Leukotrienes Essential Fatty Acids 41:215-233.
16. Gebhart GF and Sengupta JN (1995) Evaluation of visceral pain, in Handbook of Methods in Gastrointestinal Pharmacology (Gaginella T ed) pp 359-373, CRC Press. Boca Raton, FL.
17. George SR, Zastawny RL, Briones-Urbina R, Cheng R, Nguyen T, Heiber M, Kouvelas A, Chan AS and O'Dowd BF (1994) Distinct distributions of mu, delta, and kappa opioid receptor mRNA in rat brain. Biochem Biophys Res Commun 205:1438-1444.
18. 5) enkephalin, or intravenous U50,488H on the visceromotor response to colorectal distension in the rat. Anesthesiology 83:336-343.
19. Hassan AHS, Pzewlocki R, Herz A and Stein C (1992) Dynorphin, a preferential ligand for κ-opioid receptors, is present in nerve fibers and immune cells within inflamed tissue of the rat. Neurosci Lett 140:85-88.
20. Herraro JF and Headley PM (1993) Functional evidence for multiple receptor activation by κ-ligands in the inhibition of spinal nociceptive reflexes in the rat. Br J Pharmacol 110:303-309.
21. Herraro JF and Headley PM (1991) The effects of sham and full spinalization on the systemic potency of μ- and κ-opioids on spinal and nociceptive reflexes in rats. Br J Pharmacol 104:166-170.
22. Horan P, de Costa BR, Rice KC and Porecca F (1991) Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)UPHIT: Evidence of kappa opioid receptor multiplicity in mice. J Pharm Exp Ther 257:1154-1161.
23. Hunter JC, Leighton GE, Meecham KG, Boyle SJ, Howell DC, Rees DC, and Hughes J (1990) CI-977, a novel and selective agonist for the κ-opioid receptor. Br J Pharmacol 101:183-189.
24. Idänpään-Heikkilä JJ, Kalso EA and Seppälä T (1994) Antinociceptive actions of dexmedetomidine and the kappa-opioid agonist U50,488H against noxious thermal, mechanical and inflammatory stimuli. J Pharm Exp Ther 271:1306-1313.
25. Ji R-R, Zhang Q, Law P-Y, Low HH, Elde R and Hokfelt T (1995) Expression of μ-, δ-, and κ-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J Neurosci 15:8156-8166.
26. Këita H, Kayser V and Guilbaud G (1995) Antinociceptive effect of a κ-opioid receptor aponist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur J Pharm 277:275-280.
27. Kosterlitz HW, Parterson Sj and Robson LE (1981) Characterization of the kappa-subtype of the opiate receptor in the guinea pig brain. Br J Pharmacol 73:939-949.
28. Langlois A, Diop L, Rivière PJM, Pascaud X, Junien J-L (1994) Effect of fedotozine on the cardiovascular pain reflex induced by distension of the irritated rat colon in the anesthetized rat. Eur J Pharmacol 271:245-251.
29. Lauritsen IC, Laursen L, Bukhare IC and Rask-Madsen J (1988) In vivo profiles of eicosanoids in ulcerative colitiis and clostridium difficile colitis. Gastroenterology 95:11-17.
30. Leighton GE, Rodriguez RE, Hill RG and Hughes J (1988) κ-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat. Br J Pharmacol 93:553-560.
31. MacPherson BR and Pfeiffer KCJ (1978 ) Experimental production of diffuse colitis in rats. Digestion 17:135-150.
32. Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H and Watson SJ (1994) Mu, delta, and kappa, opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. J Comp Neurol 350:412-438.
33. Mansour A, Khachaturian H, Lewis ME, Akil H and Watson SJ (1987) Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosci: 7:2445-2464.
34. Mayer EA and Gebhart GF (1994) Basic and clinical aspects of visceral hyperalgesia. Gastroenterologe 107:271-293.
35. Minami M, Maekawa K, Yabuuchi K and Satoh M (1995) Double in situ hybridization study on coexistence of μ-, δ-, and κ-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia. Mol Brain Res 30:203-210.
36. Ness TJ and Gebhart GF (1988a) Colorectal distension as a noxious visceral stimulus: Physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Br Res 450:153-169.
37. Ness TJ and Gebhart GF (1988) Characterization of neurons responsive to noxious colorectal distension in the TI3-L2 spinal cord of the rat. J Neurophysiol 60:1419-143.
38. Ness TJ, Metcalf AM and Gebhart GF (1990) A psychophysiological study in humans using phasic colonie distension as a noxious visceral stimulus. Pain 43:377-386.
39. Parsons CG and Headley PM (1989) Spinal antinociceptive actions of μ- and κ-opioids: the importance of stimulus intensity in determining 'selectivity' between refelxes to different modalities of noxious stimulus. Br J Pharmacol 98:523-532.
40. Rothman RB (1994) Evidence for heterogeneity of kappa-opioid binding sites: a review of data obtained using brain membranes depleted of mu and delta binding sites with irreversible agents. Analgesia 1:27-49.
41. Schafer MK-H, Bette M, Romeo H, Schwaeble W and Weihe E (1994) Localization of κ-opioid receptor mRNA in neuronal subpopulations of rat sensory ganglia and spinal cord. Neurosci Lett 167:137-140.
42. Sengupta JN, Snider A and Gebhart GF (1997) Effect of morphine and a peripherally acting kappa-opioid receptor agonist on the visceromotor response to colonie distension in the rat. Suppl Gastroenterol 112:828.
43. Sengupta JN, Su X and Gebhart GF (1996) Kappa, but not mu or delta opioids attenuate responses to distension of pelvic nerve afferents innervating the colon of the rat. Gastroenterology 111:968-980.
44. Stein C (1993) Peripheral mechanisms of opioid analgesia. Anesth Analg 76:182-191.
45. Stein C, Millan MJ, Yassoudris A and Herz A (1988) Antinociceptive effects of μ- and κ-agonists in inflammation are enjanced by a peripheral opioid receptor-specific mechanism. Eur J Pharm 155:255-264.
46. Stevens CW and Yaksh TL (1986) Dynorphin A and related peptides administered intrathecally in the rat: A search for putative kappa opiate receptor activity. J Pharm Exp Ther 238:833-838.
47. Su X, Sengupta JS and Gebhart GF (1997a) Effects of opioids on mechanosensitive pelvic nerve afferent fibers innervating the urinary bladder of the rat. J Neurophysiol 77:1566-1580.
48. Su X, Sengupta JS and Gebhart GF (1997b) Effects of kappa opioid receptor agonists on mechanosensitive pelvic nerve afferent innervating colon of the rat. J Neurophysiol 78:1003-1012.
49. Takemori AE, Ho BY, Naeseth JS and Portoghese PS (1988) Nor-binaitorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Exp Ther 246:255-258.
50. Tempel A and Zukin RS (1987) Neuroanatomical patterns of the μ, δ, and κ opioid receptors of rat brain as determined by quantitative in vitro autoradiography. Proc Natl Acad Sci USA 84:4308-4312.
51. 2 opioid receptors. Proc Natl Acad Sci USA 85:4061-4065.