Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer

International Journal of Colorectal Disease

Volumn 16, Issue 1, 2001, Pages 38-45

  De Angelis, Paula M ^a   Stokke, Trond ^a   Beigi, Marzieh ^a   Mjåland, Odd ^b   Clausen, Ole Petter F ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Chromosomal gains losses; Colorectal tumors; Comparative genomic hybridization; Survival

Indexed keywords

DNA; PROTEIN P53;

AGED; ANEUPLOIDY; ARTICLE; CANCER GROWTH; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME 13Q; CHROMOSOME 14Q; CHROMOSOME 18Q; CHROMOSOME 1P; CHROMOSOME 20Q; CHROMOSOME 4Q; CHROMOSOME 8P; CHROMOSOME ABERRATION; CHROMOSOME ARM; CHROMOSOME LOSS; COLORECTAL CANCER; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT CANCER; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE;

ADULT; AGED; ANALYSIS OF VARIANCE; BIOPSY, NEEDLE; CHROMOSOME ABERRATIONS; COLORECTAL NEOPLASMS; CULTURE TECHNIQUES; FEMALE; HISTOLOGY, COMPARATIVE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NUCLEIC ACID HYBRIDIZATION; PROBABILITY; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECURRENCE; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS;

EID: 0035100615     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003840000275     Document Type: Article

References (41)

1. Genetic alterations during colorectal tumor development
2. Cytogenetics of colorectal adeno-carcinomas
3. Karyotypic characterization of colorectal adenocarcinomas
4. Genetic pathways in colorectal cancer
5. Genetic prognostic markers in colorectal cancer
6. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors
7. Genetic changes in primary colorectal cancer by comparative genomic hybridization
8. Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridization
9. Analysis of colorectal cancer by comparative genomic hybridization: Evidence for induction of the metastatic phenotype by loss of tumor suppressor genes
10. Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
11. Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases
12. Recurrent deletions involving chromosomes 1:5, 17, and 18 in colorectal carcinoma: Possible role in biological and clinical behavior of tumors
13. Prognostic value of chromosome 1p allelic loss in colon cancer
14. Tracking recurrent quantitative genomic alterations in colorectal cancer: Allelic losses in chromosome 4 correlate with tumor aggressiveness
15. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers
16. Allelic loss of chromosome 18q and prognosis in colorectal cancer
17. Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator
18. Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer
19. Morphological and genetic abnormalities in prediction of recurrence in radically operated colorectal cancer
20. Prognostic significance of allelic loss at chromosome 18q21 for stage II colorectal cancer
21. Near diploid large bowel carcinomas have better five-year survival than aneuploid ones
22. Flow cytometric DNA index in the prognosis of colorectal cancer
23. Overexpression of p53 and long-term survival in colon carcinoma
24. Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon
25. Prognostic significance of p53 abnormalities in colorectal carcinoma detected by PCR-SSCP and immunohistochemical analysis
26. Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma
27. Prognostic value of p53 genetic changes in colorectal cancer
28. Apoptosis and expression of bax, bcl-x, and bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and associations with TP53 genotype/phenotype
29. Deletion mapping in colorectal cancer of a putative tumor suppressor gene in 8p22-p21.3
30. Evidence for the presence of two tumor suppressor genes on chromosome 8p for colorectal carcinoma
31. Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumor suppressor loci involved in colorectal cancer
32. Functional evidence for a colorectal cancer tumor suppressor gene at chromosome 8p22-23 by monochromosome transfer
33. Chromosome 8 losses in colorectal carcinoma: Localization and correlation with invasive disease
34. Deletion mapping of the tumor suppressor locus involved in colorectal cancer on chromosome band 8p21
35. Loss of heterozygosity of 14q32 in colorectal carcinomas
36. Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization
37. MADR2 maps to 18q21 and encodes a TGFβb-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
38. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
39. Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers
40. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
41. Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas