메뉴 건너뛰기




Volumn 19, Issue 2, 2003, Pages 159-163

The Pro12Ala PPARγ2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men

Author keywords

Genes; Hormones; Insulin; Obesity; Polymorphism; PPAR 2

Indexed keywords

ALANINE; FAT; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HORMONE; HYDROCORTISONE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROLINE; RESTRICTION ENDONUCLEASE; CELL RECEPTOR; TRANSCRIPTION FACTOR;

EID: 0037359269     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.371     Document Type: Article
Times cited : (47)

References (33)
  • 1
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-γ: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998; 47: 507-514.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 2
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature 2000; 405: 421-424.
    • (2000) Nature , vol.405 , pp. 421-424
    • Kersten, S.1    Desvergne, B.2    Wahli, W.3
  • 3
    • 0035136940 scopus 로고    scopus 로고
    • Progress in cardiovascular biology: PPAR for the course
    • Lazar MA. Progress in cardiovascular biology: PPAR for the course. Nat Med 2001; 7(1): 23-24.
    • (2001) Nat. Med. , vol.7 , Issue.1 , pp. 23-24
    • Lazar, M.A.1
  • 4
    • 0030590074 scopus 로고    scopus 로고
    • Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2
    • Elbrecht A, Chen Y, Cullinan CA, et al. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem Biophys Res Commun 1996; 224: 431-437.
    • (1996) Biochem. Biophys. Res. Commun. , vol.224 , pp. 431-437
    • Elbrecht, A.1    Chen, Y.2    Cullinan, C.A.3
  • 5
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 2000; 106: 467-472.
    • (2000) J. Clin. Invest. , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 6
    • 0031589186 scopus 로고    scopus 로고
    • Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-γ (hPPARγ) gene
    • Beamer BA, Negri C, Yen CJ, et al. Chromosomal localization and partial genomic structure of the human peroxisome proliferator activated receptor-γ (hPPARγ) gene. Biochem Biophys Res Commun 1997; 233: 756-759.
    • (1997) Biochem. Biophys. Res. Commun. , vol.233 , pp. 756-759
    • Beamer, B.A.1    Negri, C.2    Yen, C.J.3
  • 7
    • 0030835678 scopus 로고    scopus 로고
    • The organization, promoter analysis, and expression of the human PPARγ gene
    • Fajas L, Auboeuf D, Raspe E, et al. The organization, promoter analysis, and expression of the human PPARγ gene. J Biol Chem 1997; 272: 18 779-18 789.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18779-18789
    • Fajas, L.1    Auboeuf, D.2    Raspe, E.3
  • 8
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med 1998; 339: 953-959.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 9
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20: 284-287.
    • (1998) Nat. Genet. , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 10
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation
    • Yen CJ, Beamer BA, Negri C, et al. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 1997; 241: 270-274.
    • (1997) Biochem. Biophys. Res. Commun. , vol.241 , pp. 270-274
    • Yen, C.J.1    Beamer, B.A.2    Negri, C.3
  • 11
    • 0032589053 scopus 로고    scopus 로고
    • The PPARγ2 amino acid polymorphism Pro12Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
    • Koch M, Rett K, Maerker E, et al. The PPARγ2 amino acid polymorphism Pro12Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. Diabetologia 1999; 42: 758-762.
    • (1999) Diabetologia , vol.42 , pp. 758-762
    • Koch, M.1    Rett, K.2    Maerker, E.3
  • 12
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women
    • Valve R, Sivenius K, Miettinen R, et al. Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 1999; 84: 3708-3712.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3708-3712
    • Valve, R.1    Sivenius, K.2    Miettinen, R.3
  • 13
    • 0001491179 scopus 로고    scopus 로고
    • Impact of the peroxisome proliferator activated receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
    • Meirhaeghe A, Fajas L, Helbecque N, et al. Impact of the peroxisome proliferator activated receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus. Int J Obes Relat Metab Disord 2000; 24: 195-199.
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 195-199
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3
  • 14
    • 0034036693 scopus 로고    scopus 로고
    • Variation in the gene for human peroxisome proliferator activated receptor γ (PPARγ) does not play a major role in the development of morbid obesity
    • Evans D, Mann WA, Heer J, et al. Variation in the gene for human peroxisome proliferator activated receptor γ (PPARγ) does not play a major role in the development of morbid obesity. Int J Obes Relat Metab Disord 2000; 24: 647-651.
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 647-651
    • Evans, D.1    Mann, W.A.2    Heer, J.3
  • 15
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26: 76-80.
    • (2000) Nat. Genet. , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 16
    • 0004509649 scopus 로고    scopus 로고
    • The Pro115Gln and Pro12Ala PPARγ gene mutations in obesity and type 2 diabetes
    • Clement K, Hercberg S, Passinge B, et al. The Pro115Gln and Pro12Ala PPARγ gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord 2000; 24: 391-393.
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 391-393
    • Clement, K.1    Hercberg, S.2    Passinge, B.3
  • 17
    • 0035093082 scopus 로고    scopus 로고
    • Effect of the peroxisome proliferator-activated receptor-γ2 Pro12Ala variant on obesity, glucose homeostasis, and blood pressure in members of familial Type 2 diabetic kindreds
    • Hasstedt SJ, Ren Q-F, Teng K, Elbein SC. Effect of the peroxisome proliferator-activated receptor-γ2 Pro12Ala variant on obesity, glucose homeostasis, and blood pressure in members of familial Type 2 diabetic kindreds. J Clin Endocrinol Metab 2001; 86: 536-541.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 536-541
    • Hasstedt, S.J.1    Ren, Q.-F.2    Teng, K.3    Elbein, S.C.4
  • 18
    • 0031732443 scopus 로고    scopus 로고
    • Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities
    • Rosmond R, Dallman MF, Björntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 1998; 83: 1853-1859.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1853-1859
    • Rosmond, R.1    Dallman, M.F.2    Björntorp, P.3
  • 19
    • 0033694380 scopus 로고    scopus 로고
    • Hypertension in obesity and the leptin receptor gene locus
    • Rosmond R, Chagnon YC, Holm G, et al. Hypertension in obesity and the leptin receptor gene locus. J Clin Endocrinol Metab 2000; 85: 3126-3131.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3126-3131
    • Rosmond, R.1    Chagnon, Y.C.2    Holm, G.3
  • 20
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 21
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63.
    • (2000) Diabetes Care , vol.23 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3
  • 22
    • 0032781890 scopus 로고    scopus 로고
    • Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-γ2 (PPAR-γ2): Divergent modulating effects on body mass index in obese and lean Caucasian men
    • Ek J, Urhammer SA, Sorensen TI, Andersen T, Auwerx J, Pedersen O. Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-γ2 (PPAR-γ2): divergent modulating effects on body mass index in obese and lean Caucasian men. Diabetologia 1999; 42: 892-895.
    • (1999) Diabetologia , vol.42 , pp. 892-895
    • Ek, J.1    Urhammer, S.A.2    Sorensen, T.I.3    Andersen, T.4    Auwerx, J.5    Pedersen, O.6
  • 23
    • 0039379120 scopus 로고    scopus 로고
    • Obesity
    • Björntorp P. Obesity. Lancet 1997; 350: 423-426.
    • (1997) Lancet , vol.350 , pp. 423-426
    • Björntorp, P.1
  • 24
    • 0000862587 scopus 로고    scopus 로고
    • The sagittal diameter is a valid marker of the visceral adipose tissue volume
    • Angel A, Andersson H, Bouchard C, Lau L, Leiter L, Mendelson R (eds). John Libbey & Co: London
    • Sjöström L, Lönn L, Chowdhury B, et al. The sagittal diameter is a valid marker of the visceral adipose tissue volume. In Progress in Obesity Research: 7, Angel A, Andersson H, Bouchard C, Lau L, Leiter L, Mendelson R (eds). John Libbey & Co: London, 1996; 309-319.
    • (1996) Progress in Obesity Research: 7 , pp. 309-319
    • Sjöström, L.1    Lönn, L.2    Chowdhury, B.3
  • 25
    • 13144307062 scopus 로고    scopus 로고
    • Endocrine and metabolic aberrations in men with abdominal obesity in relation to anxio-depressive infirmity
    • Rosmond R, Björntorp P. Endocrine and metabolic aberrations in men with abdominal obesity in relation to anxio-depressive infirmity. Metabolism 1998; 47: 1187-1193.
    • (1998) Metabolism , vol.47 , pp. 1187-1193
    • Rosmond, R.1    Björntorp, P.2
  • 26
    • 0031736272 scopus 로고    scopus 로고
    • The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men
    • Rosmond R, Björntorp P. The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men. Int J Obes Relat Metab Disord 1998; 22: 1184-1196.
    • (1998) Int. J. Obes. Relat. Metab. Disord. , vol.22 , pp. 1184-1196
    • Rosmond, R.1    Björntorp, P.2
  • 27
    • 0033849842 scopus 로고    scopus 로고
    • Insights into insulin resistance and type 2 diabetes from knockout mouse models
    • Kadowaki T. Insights into insulin resistance and type 2 diabetes from knockout mouse models. J Clin Invest 2000; 106: 459-465.
    • (2000) J. Clin. Invest. , vol.106 , pp. 459-465
    • Kadowaki, T.1
  • 28
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
    • Barroso I, Gurnell M, Crowley VE, et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999; 402: 880-883.
    • (1999) Nature , vol.402 , pp. 880-883
    • Barroso, I.1    Gurnell, M.2    Crowley, V.E.3
  • 29
    • 0034099418 scopus 로고    scopus 로고
    • Analysis of the peroxisome proliferator activated receptor γ (PPARγ) gene in HAIRAN syndrome with obesity
    • Globerman H, Zauberman Y, Makarov T, et al. Analysis of the peroxisome proliferator activated receptor γ (PPARγ) gene in HAIRAN syndrome with obesity. Clin Endocrinol (Oxf) 2000; 52: 479-485.
    • (2000) Clin. Endocrinol. (Oxf) , vol.52 , pp. 479-485
    • Globerman, H.1    Zauberman, Y.2    Makarov, T.3
  • 30
    • 0345363159 scopus 로고    scopus 로고
    • Missense variants in the human peroxisome proliferator-activated receptor-γ2 gene in lean and obese subjects
    • Hamann A, Munzberg H, Buttron P, et al. Missense variants in the human peroxisome proliferator-activated receptor-γ2 gene in lean and obese subjects. Eur J Endocrinol 1999; 141: 90-92.
    • (1999) Eur. J. Endocrinol. , vol.141 , pp. 90-92
    • Hamann, A.1    Munzberg, H.2    Buttron, P.3
  • 31
    • 0033582258 scopus 로고    scopus 로고
    • Pro12Ala missense mutation of the peroxisome proliferator activated receptor γ and diabetes mellitus
    • Ringel J, Engeli S, Distler A, Sharma AM. Pro12Ala missense mutation of the peroxisome proliferator activated receptor γ and diabetes mellitus. Biochem Biophys Res Commun 1999; 254: 450-453.
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 450-453
    • Ringel, J.1    Engeli, S.2    Distler, A.3    Sharma, A.M.4
  • 32
    • 0036557328 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity
    • Celi FS, Shuldiner AR. The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity. Curr Diabetes Rep 2002; 2: 179-185.
    • (2002) Curr. Diabetes Rep. , vol.2 , pp. 179-185
    • Celi, F.S.1    Shuldiner, A.R.2
  • 33
    • 0034741548 scopus 로고    scopus 로고
    • 3-adrenergic receptor and peroxisome proliferator-activated receptor-γ2 genes and obesity
    • 3-adrenergic receptor and peroxisome proliferator-activated receptor-γ2 genes and obesity. Diabetes Care 2001; 24: 672-677.
    • (2001) Diabetes Care , vol.24 , pp. 672-677
    • Hsueh, W.C.1    Cole, S.A.2    Shuldiner, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.