Evidence for distinct genetic effects on obesity and lipid-related CVD risk factors in diabetic compared to nondiabetic American Indians: The Strong Heart Family Study

Diabetes/Metabolism Research and Reviews

Volumn 19, Issue 2, 2003, Pages 140-147

  North, Kari E ^a   MacCluer, Jean W ^b   Williams, Jeff T ^b   Welty, Thomas K ^g   Best, Lyle G ^c   Lee, Elisa T ^d   Fabsitz, Richard R ^e   Howard, Barbara V ^f  

^a IL   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c MISSOURI BREAKS INDUSTRIES RESEARCH INC   (United States)

^d UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^f MEDSTAR RESEARCH INSTITUTE   (United States)

^g NONE

Author keywords

American Indians; CVD risk factors; Diabetes; Genetic effects; Strong Heart Family Study

Indexed keywords

ALBUMIN; CREATININE; FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; ORAL ANTIDIABETIC AGENT; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRIACYLGLYCEROL;

ADULT; AGED; AMERICAN INDIAN; ANTHROPOMETRY; ARTICLE; BODY FAT; BODY MASS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FAMILY; FEMALE; GENE INTERACTION; GENETIC PREDISPOSITION; GENETIC SCREENING; GLUCOSE TOLERANCE TEST; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MAXIMUM LIKELIHOOD METHOD; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; URINE LEVEL;

AGED; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIANS, NORTH AMERICAN; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; RISK FACTORS;

EID: 0037359256     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.355     Document Type: Article

References (61)

1. Labarthe DR. Epidemiology and Prevention of Cardiovascular Disease: A Global Challenge, Aspen Publishers: Gaithersburg, MD, 1998.
2. Howard BV, Lee ET, Cowan LD, et al. Rising tide of cardiovascular disease in American Indians: the strong heart study. Circulation 1999; 99: 2389-2395.
3. Mitchell BD. Macrovascular disease in diabetes. In Diabetes: Clinical Science in Practice, Leslie RDG, Robbins DC (eds). Cambridge University Press: Cambridge, UK, 1995; 222-236.
4. Laakso M, Lehto S. Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance. Atherosclerosis 1998; 137(Suppl.): S65-S73.
5. Galloway JM, Alpert JS. Coronary artery disease and hypertension. In Primary care of Native American Patients: Diagnosis, Therapy, and Epidemiology, Galloway JM, Goldberg BW, Alpert JS (eds). Butterwoth-Heinemann: Woburn, MA, 1999; 125-131.
6. Welty TK, Rhoades DA, Yeh F, et al. Changes in cardiovascular disease risk factors and American Indians: the strong heart study. Ann Epidemiol 2002; 12(2): 97-106.
7. Lee ET, Cowan LD, Welty TK, et al. All-cause mortality and cardiovascular disease mortality in three American Indian populations, aged 45-74 years, 1984-88: the strong heart study. Am J Epidemiol 1998; 147(11): 995-1008.
8. North KE, Howard BV, Best L, Lee E, Fabsitz RR, MacCluer JW. The strong heart family study: genetic and environmental contributions to cardiovascular disease risk factors in American Indians. Am J Epidemiol; in press.
9. Lee ET, Welty TK, Fabsitz RR, et al. The strong heart study: a study of cardiovascular disease in American Indians: design and methods. Am J Epidemiol 1990; 132(6): 1141-1155.
10. Howard BV, Lee ET, Cowan L, et al. Coronary heart disease prevalence and its relation to heart disease in American Indians: the strong heart study. Am J Epidemiol 1995; 142: 254-268.
11. Liedtke RJ. Principles of Bioelectric Impedance Analysis [article online], 1997. Available from www.rjlsystems.com/research/bia-principles.html.
12. Howard BV, Welty TK, Fabsitz RR, et al. Risk factors for coronary heart disease in diabetic and non-diabetic native Americans: the strong heart study. Diabetes 1992; 41 (Suppl. 2): 4-11.
13. Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
14. Geffken D, Keating F, Kennedy M, Cornell E, Bovill E, Tracy R. The measurement of fibrinogen in population-based research: Studies on instrumentation and methodology. Arch Pathol Lab Med 1994; 118: 1106-1109.
15. DeClerck PJ, Alessi MC, Verstreken M, Kruithof EK, Juhan-Vague I, Collen D. Measurement of plasminogen inhibitor 1 in biologic fluids with a murine antibody-based enzyme-linked immunosorbent assay. Blood 1988; 71(1): 220-225.
16. Alberti KG, Zimmet PZ. Definition, diagnosis, and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med 1998; 15(7): 539-553.
17. Falconer DS. Introduction to Quantitative Genetics (3rd edn), Longman: Essex, UK, 1989.
18. Amos CI. Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 1994; 54: 535-543.
19. Hopper JL, Mathews JD. Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet 1982; 46: 373-383.
20. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62: 1198-1211.
21. Towne B, Blangero J, Mott GE. Genetic analysis of sexual dimorphism in serum apo A1 and HDL-C concentrations in baboons. Am J Primatol 1992; 27: 107-117.
22. Comuzzie AG, Blangero J, Mahaney MC, Mitchell BD, Stern MP, MacCluer JW. The quantitative genetics of sexual dimorphism in body fat measurements. Am J Hum Biol 1993; 5: 725-734.
23. Robertson A. The sampling variance of the genetic correlation coefficient. Biometrics 1959; 15: 469-485.
24. Eisen EJ, Legates JE. Genotype-sex interaction and the genetic correlation between the sexes for body weight in Mus musculus. Genetics 1966; 54(2): 611-623.
25. Self SG, Liang KY. Asymptotic properties of maximum likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 1987; 82: 605-610.
26. Williams JT, Van Eerdewegh P, Almasy L, Blangero J. Joint multipoint analysis of multivariate qualitative and quantitative traits. I. Likelihood formation and simulation results. Am J Hum Genet 1999; 65: 1134-1147.
27. Williams JT, Begleiter H, Porjesz B, et al. Joint multipoint analysis of multivariate qualitative and quantitative traits II. Alcoholism and event-related potentials. Am J Hum Genet 1999; 65: 1148-1160.
28. Beaty TH, Self SG, Liang KY, Connolly MA, Chase GA, Kwiterovich PO. Use of robust variance component models to analyze triglyceride data in families. Ann Hum Genet 1985; 49: 315-328.
29. Allison DB, Neale MC, Zannoli R, Schork N, Amos CI, Blangero J. Testing the robustness of the likelihood ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet 1999; 65(2): 531-544.
30. Lange KL, Little RJA, Taylor JMG. Robust statistical modeling using the t distribution. J Am Stat Assoc 1989; 85: 881-896.
31. Lee ET, Welty TK, Cowan LD, et al. Incidence of diabetes mellitus in American Indians of three geographic areas: the strong heart study. Diabetes Care 2002; 25(1): 49-54.
32. Knowler WC, Saad MF, Pettitt DJ, Nelson RG, Bennett PH. Determinants of diabetes mellitus in Pima Indians. Diabetes Care 1993; 16: 216-227.
33. Ohlson LO, Larsson B, Svardsudd K, et al. The influence of body fat distribution on the incidence of diabetes mellitus: 13.5 years of follow-up of the participants in the study of men born 1913. Diabetes 1985; 34(10): 1055-1058.
34. Ramachandran A, Snehalatha C, Satyavani K, Sivasankari S, Vijay V. Cosegregation of obesity with familial aggregation of type 2 diabetes mellitus. Diabetes Obes Metab 2000; 2(3): 149-154.
35. Fagot-Campagna A, Venkat Narayan KM, Hanson RL, et al. Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in women. Atherosclerosis 1997; 128: 113-119.
36. Legato MJ. Dyslipidemia, gender, and the role of high-density lipoprotein cholesterol: implications for therapy. Am J Cardiol 2000; 86(12; Suppl 1): 15-18.
37. Tenkanen L, Manttari M, Manninen V. Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil. Experience from the Helsinki heart study. Circulation 1995; 92(7): 1779-1785.
38. Cefalu WT. Insulin resistance: cellular and clinical concepts. Exp Biol Med 2001; 226: 13-26.
39. Kaplan NM. The deadly quartet. Upper body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989; 149: 1514-1520.
40. Howard BV. Insulin resistance and lipid metabolism. Am J Cardiol 1999; 84: J J 28-32.
41. DeFronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-194.
42. Wallenstein S, Zucker C, Fleiss J. Some statistical methods useful in circulation research. Circ Res 1980; 47: 1-9.
43. Fujii S, Goto D, Zaman T, et al. Diminished fibrinolysis and thrombosis: clinical implications for accelerated atherosclerosis. J Atheroscl Thromb 1998; 5(2): 76-81.
44. Bastard JP, Pieroni L, Hainque B. Relationship between plasma plasminogen activator inhibitor I and insulin resistance. Diabetes Metab Res Rev 2000; 16(3): 192-201.
45. Eliason M, Asplund K, Ervin PE. Regular leisure time physical activity predicts high activity of tissue plasminogen activator: the Northern Sweden MONICA study. Int J Epidemiol 1996; 25(6): 1182-1188.
46. Scarabin PY, Aillaud MF, Amouyel P, et al. Associations of fibrinogen, factor VII, and PAI-1 with baseline findings among 10,500 male participants in a prospective study of myocardial infarction: the PRIME study. Thromb Haemost 1998; 80(5): 749-756.
47. Bjorntorp P, Rosmond R. Visceral obesity and diabetes. Drugs 1999; 58(Suppl. 1): 13-18.
48. Seidell JC. Obesity, insulin resistance and diabetes - a worldwide epidemic. Br J Nutr 2000; 83(Suppl. 1): S5-S8.
49. Reaven GM. Non-insulin-dependent diabetes mellitus, abnormal lipoprotein metabolism, and atherosclerosis. Metabolism 1987; 36(Suppl. 1): 1-8.
50. Larsen JL. Dyslipidemia in diabetes: a comprehensive analysis. Adv Nurse Pract 1998; 6(4): 36-43.
51. Haffner SM. Management of dyslipidemia in adults with diabetes. Diabetes Care 1998; 21(1): 160-178.
52. Corominola H, Conner LJ, Beavers LS, et al. Identification of novel genes differentially expressed in omental fat or obese subjects and obese type 2 diabetic patients. Diabetes 2001; 50(12): 2822-2830.
53. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991; 34: 416-422.
54. Despres JP, Lamarche B, Mauriege P, Cantin B, Lupien PJ, Dagena GR. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952-957.
55. Mitchell BD, Kammerer CK, Mahaney MC, et al. Genetic analysis of the IRS pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscl, Thromb, Vascular Biol 1996; 16(2): 281-288.
56. Allison DB, Heshka S, Heymsfield SB. Evidence of a major with pleiotropic action for a cardiovascular disease risk syndrome in children younger than 14 years. Am J Dis Child 1993; 147: 1298-1302.
57. Carmelli D, Cardon LR, Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet 1994; 55: 566-573.
58. Mahaney MC, Blangero J, Comuzzie AG, Van de Berg JL, Stern MP, MacCluer JW. Plasma HDL cholesterol, triglycerides, and adiposity: a quantitative test of the cojoint trait hypothesis in the San Antonio family heart study. Circulation 1995; 92: 3240-3248.
59. Hong Y, Pedersen NL, Brismar K, de Faire U. Genetic and environmental architecture of features of insulin resistance syndrome. Am J Hum Genet 1997; 60: 143-152.
60. Edwards KL, Newman B, Mayer E, Selby JV, Krauss RM, Austin MA. Heritability of factors of the insulin resistance syndrome in women twins. Genet Epidemiol 1997; 14: 241-253.
61. Duggirala R, Williams K, Arya R, Blangero J, Stern MP. Genetic factors underlying the insulin resistance syndrome in nondiabetic Mexican Americans. Am J Hum Biol 2000; 12(2): 274.