Intravesical capsaicin for treatment of severe bladder pain: A randomized placebo controlled study

Journal of Urology

Volumn 156, Issue 3, 1996, Pages 947-952

  Lazzeri, M ^a   Beneforti, P ^a   Benaim, G ^a   Maggi, C A ^a   Lecci, A ^a   Turini, D ^a  

^a NONE

Author keywords

bladder diseases; capsaicin; pain

Indexed keywords

CAPSAICIN; PLACEBO;

ADULT; ANALGESIA; ARTICLE; BLADDER DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; INTRAVESICAL DRUG ADMINISTRATION; MALE; MICTURITION DISORDER; NOCTURIA; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT OUTCOME;

EID: 0029776444     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)65669-6     Document Type: Article

References (28)

1. Baskin, L. S. and Tanagho, E. A.: Pelvic pain without pelvic organs J. Urol., 147: 683, 1992.
2. Duke, W.: Elusive ulcer of the bladder. Surg., Gynec. & Obst., 35: 759, 1922.
3. Fister, G. M.: Similarity of interstitial cystitis (Hunner ulcer) to lupus erythematosus. J. Urol., 40: 37, 1938.
4. Kreutzmann, H. A. R.: The treatment of Hunner's ulcer with deep x-ray therapy. J. Urol., 46: 907, 1941.
5. Guerrier, H. P., Roberts, J. B. M. and Slade, N.: Antiinflammatory agents in the management of interstitial cystitis. Brit. J. Urol., 37: 88, 1965.
6. Simmons, J. L. and Bunce, P. L.: On the use of antihistamine in the treatment of interstitial cystitis. Amer. Surg., 24: 664, 1958.
7. Weaver, R. G., Dougherty, T. F. and Natoli, C. A.: Recent concepts of interstitial cystitis. J. Urol., 89: 377, 1963.
8. Messing, E. M. and Stamey, T. A.: Interstitial cystitis: early diagnosis, pathology, and treatment. Urology, 12: 381, 1978.
9. Fall, M., Carlsson, C.-A. and Erlandson, B.-E.: Electrical stimulation in interstitial cystitis. J. Urol., 123: 192, 1980.
10. Chahl, L. A., Lembeck, F. and Szolcsanyi, J.: Antidromic Vasodilatation and Neurogenic Inflammation. Budapest: Akadem'emiai Kiad'o, 1984.
11. Craft, R. M. and Porreca, F.: Treatment parameters of desensitization to capsaicin. Life Sci., 51: 1767, 1992.
12. Fowler, C. J., Jewkes, D., McDonald, W. I., Lynn, B. and de Groat, W. C.: Intravesical capsaicin for neurogenic bladder dysfunction. Lancet, 339: 1239, 1992.
13. Fowler, C. J., Beck, R. O., Gerrard, S., Betts, C. D. and Fowler, C. G.: Intravesical capsaicin for treatment of detrusor hyperreflexia J. Neurol. Neurosurg. Psychiatr., 57: 169, 1994.
14. Barbanti, G., Maggi, C. A., Beneforti, P., Baroldi, P. and Turini, D.: Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract. Brit. J. Urol., 71: 686, 1993.
15. Koziol, J. A., Clark, D. C., Gittes, R. F. and Tan, E. M.: The natural history of interstitial cystitis: a survey of 374 patients J. Urol., 149: 465, 1993.
16. Friedman, M.: The use of ranks to avoid the assumption of normality implicit in the analysis of variance. J. Amer. Stat. Ass., 32: 675, 1937.
17. Newman, D.: The distribution of range in samples from a normal population, expressed in terms of an independent estimate of standard deviation. Biometrika, 31: 20, 1939.
18. Keuls, M.: The use of "studentized range" in connection with an analysis of variance. Euphytica, 1: 112, 1952.
19. Clarke, I. M. C.: Peppering pain. Lancet, 342: 1130, 1993.
20. Albelli, L., Conte, B., Somma, V., Maggi, C. A., Giuliani, S. and Meli, A.: A method for studying pain arising from the urinary bladder in conscious, freely-moving rats. J. Urol., 141: 148, 1989.
21. Giuliani, S., Maggi, C. A. and Meli, A.: Capsaicin-sensitive afferents in the rat urinary bladder activate a spinal sympathetic cardiovascular reflex. Naunyn. Schmiedebergs Arch. Pharmacol., 338: 411, 1988.
22. Maggi, C. A., Santicioli, P., Geppetti, P., Parlani, M., Astolfi, M., Del Bianco, E., Patacchini, R., Giuliani, S. and Meli, A.: The effect of calcium free medium and nifedipine on the release of substance P-like immunoreactivity and contractions induced by capsaicin in the isolated guinea-pig and rat bladder. Gen. Pharmacol., 20: 445, 1989.
23. Holzer, P.: Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience, 24: 739, 1988.
24. Maggi, C. A., Lecci, A., Abelli, L. and Giuliani, S.: The role of capsaicin-sensitive afferents in the genesis of vesical pain and inflammation. In: New Trends in Referred Pain and Hyperalgesia. Edited by L. Vecchiet, D. Albe-Fessard, U. Lindblom and M. A. Giamberardino. New York: Elsevier Science Publishing
25. Turner, J. A., Deyo, R. A., Loeser, J. D., Von Korff, M. and Fordyce, W. E.: The importance of placebo effects in pain treatment and research. J.A.M.A., 271: 1609, 1994.
26. Dymond, E. C., Kittle, C. F. and Crocket, J. E.: Comparison of internal mammary ligation and sham operation for angina pectoris. Amer. J. Cardiol., 5: 483, 1960.
27. Buckalew, L. W. and Coffield, K. E.: An investigation of drug expectancy as a function of capsule color and size and preparation form. J. Clin. Psychopharmacol., 2: 245, 1982.
28. Blackwell, B., Bloomfield, S. S. and Buncher, C. R.: Demonstration to medical students of placebo responses and non-drug factors. Lancet, 1: 1279, 1972.