Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR

Chemical Research in Toxicology

Volumn 15, Issue 1, 2002, Pages 48-62

  Mutlib, Abdul E ^a   Shockcor, John ^a   Chen, Shiang Yuan ^a   Espina, Robert J ^a   Pinto, Donald J ^a   Orwat, Michael J ^a   Prakash, Shimoga R ^a   Gan, Liang Shang ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (AMINOMETHYL)PHENYL] N [3 FLUORO 2' (METHYLSULFONYL) 1,1' BIPHENYL 4 YL] 3 (TRIFLUOROMETHYL) 1H PYRAZOLE 5 CARBOXAMIDE; ALDEHYDE; AMIDE; AMINE OXIDASE (FLAVIN CONTAINING); BENZYL ALCOHOL; BENZYLAMINE; CARBOXYLIC ACID; GLUCURONIDE; OXIME; PHENOL DERIVATIVE; SEMICARBAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; CHIMPANZEE; DOG; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; REACTION ANALYSIS; RHESUS MONKEY; SPECIES DIFFERENCE;

ADULT; AGED; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FACTOR XA; FIBRINOLYTIC AGENTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; MIDDLE AGED; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; SULFONES;

CANIS FAMILIARIS; MACACA MULATTA; ORYCTOLAGUS CUNICULUS; PAN TROGLODYTES; RODENTIA;

EID: 0036153976     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0101191     Document Type: Article

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