The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol

Journal of Neuroscience

Volumn 21, Issue 14, 2001, Pages 5297-5303

  Wand, Gary ^a   Levine, Michael ^a   Zweifel, Larry ^a   Schwindinger, William ^c   Abel, Ted ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WEIS CENTER FOR RESEARCH   (United States)

Author keywords

Adenylyl cyclase; Alcohol; Alcoholism; cAMP; Protein kinase A; Sedation

Indexed keywords

ADENYLATE CYCLASE; ALCOHOL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DISRUPTION; LIMBIC SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEDATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0035879273     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-14-05297.2001     Document Type: Article

References (30)

1. Positive and negative regulatory mechanisms that mediate long-term memory storage
2. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
3. Memory suppressor genes: Inhibitory constraints on the storage of long-term memory
4. 2+ channel by coexpression of G(alpha s) in Xenopus oocytes
5. Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors
6. A genetic study of platelet adenylate cyclase activity: Evidence for a single major locus effect in fluoride-stimulated activity
7. Genetics of alcoholism: A review of recent studies in human and animal models
8. Adenylyl cyclase signal transduction and alcohol-induced sedation
9. Nucleoside transport in lymphocytes from alcoholics and non-alcoholics
10. The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins
11. Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon
12. Ethanol and guanine nucleotide binding proteins: A selective interaction
13. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
14. Cyclic AMP-dependent protein kinase decreases gamma-aminobutyric acidA receptor-mediated 36Cl- uptake by brain microsacs
15. Effects of abstinence and family history for alcoholism on platelet adenylyl cyclase activity
16. Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway
17. cFos induction during conditioned taste aversion expression varies with aversion strength
18. Platelet adenylyl cyclase activity in alcoholics and subtypes of alcoholics
19. The 1994 Isaacson Award Lecture: A prospective study of sons of alcoholics
20. Genetics of the risk for alcoholism
21. Targeted disruption of Gnas in embryonic stem cells
22. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
23. The dopamine hypothesis of reward: Past and current status
24. Differences in platelet enzyme activity between alcoholics and nonalcoholics
25. Ethanol consumption and resistance are inversely related to neuropeptide Y levels
26. High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice
27. Enhanced expression of the inhibitory protein Gi2 alpha and decreased activity of adenylyl cyclase in lymphocytes of abstinent alcoholics
28. Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism
29. Molecular and functional diversity of the expanding GABA-A receptor gene family
30. Native 5-HT1B receptors expressed in OK cells display dual coupling to elevation of intracellular calcium concentrations and inhibition of adenylate cyclase