Bone anabolic effects of Sonic/Indian hedgehog are mediated by BMP-2/4-dependent pathways in the neonatal rat metatarsal model

Endocrinology

Volumn 142, Issue 2, 2001, Pages 940-947

  Krishnan, V ^a   Ma, Y L ^a   Moseley, J M ^a   Geiser, A G ^a   Friant, S ^a   Frolik, C A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; MESSENGER RNA; NOGGIN; PARATHYROID HORMONE RELATED PROTEIN; SONIC HEDGEHOG PROTEIN;

ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BONE METABOLISM; BONE MINERALIZATION; CONTROLLED STUDY; DOSE RESPONSE; ENCHONDRAL OSSIFICATION; METATARSAL BONE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TARGETING; RAT;

EID: 0035106438     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.2.7922     Document Type: Article

References (31)

1. OP-1 (BMP-7) affects mRNA expression of type 1, II, X collagen, and matrix Gla protein in ossifying long bones in vitro
2. Cloning, expression and chromosomal localization of Shh and Ihh, two human homologues of the Drosophila segment polarity gene hedgehog
3. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
4. The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
5. Interaction of Ihh and BMP Noggin signaling during cartilage differentiation
6. PTHrP and Ihh control the pace of cartilage differentiation
7. Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related protein-dependent and -independent pathways
8. Natriuretic peptide regulation of endochondral ossification
9. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
10. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein-4
11. Intermittent on/off prostaglandin E2 and risedronate are equally anabolic as daily PGE2 alone treatment in cortical bone of ovariectomized rats
12. Characterisation of an osteoblast-like clonal cell line which responds to bone parathyroid hormone and calcitonin
13. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
14. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation
15. Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells
16. Runt homology domain proteins in osteoblast differentiation: AML3/Cbfa1 is a major component of a bone specific complex
17. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair
18. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
19. Genetic control of cell differentiation in the skeleton
20. Developmental patterning in chondrocytic cultures by morphogenic gradients: BMP induces expression of Indian hedgehog and noggin
21. Common molecular pathways in skeletal morphogenesis and repair
22. Expression of Indian hedgehog in osteoblasts and its posttranscriptional regulation by transforming growth factor-β
23. Maturational disturbance of chondrocytes in Cbfa1-deficient mice
24. Cbfa1 in bone development
25. Regulation of chondrocyte differentiation by Cbfa1
26. Sonic hedgehog mediates the polarizing activity of the ZPA
27. The long and short of hedgehog signaling
28. Noggin acts downstream of Wnt and sonic hedgehog to antagonize BMP4 in avian somite patterning
29. Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite
30. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development