Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 3, 2003, Pages 1188-1193

  Halpern, John H ^a,b   Sholar, Michelle B ^a   Glowacki, Julie ^b   Mello, Nancy K ^a   Mendelson, Jack H ^a   Siegel, Arthur J ^a  

^a MCLEAN HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COCAINE; CORTICOSTEROID; CORTICOTROPIN; HYDROCORTISONE; INTERLEUKIN 6; PLACEBO; POLYPEPTIDE; PRASTERONE;

ADULT; ANTIGEN BINDING; ARTICLE; BLOOD SAMPLING; CATHETERIZATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL TRIAL; COCAINE DEPENDENCE; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE MODEL; DRUG ABUSE; FEMALE; GENDER; HOST SUSCEPTIBILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMORAL IMMUNITY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSTIMULATION; INDWELLING CATHETER; INFECTION RATE; INFECTION RISK; INFLAMMATION; INTERMETHOD COMPARISON; MALE; MENSTRUAL CYCLE; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; STEROID RELEASE; TIME; TWO TAILED T TEST; VEIN BLOOD FLOW;

ADRENOCORTICOTROPIC HORMONE; ADULT; COCAINE; DEHYDROEPIANDROSTERONE; FEMALE; HUMANS; HYDROCORTISONE; INJECTIONS, INTRAVENOUS; INTERLEUKIN-6; MALE; MENSTRUAL CYCLE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0037338811     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020804     Document Type: Article

References (48)

1. Calogero AE, Gallucci WT, Kling MA, Chrousos GP, Gold PW 1989 Cocaine stimulates rat hypothalamic corticotropin-releasing hormone secretion in vitro. Brain Res 505:7-11
2. River C, Vale W 1987 Cocaine stimulates adrenocorticotropin (ACTH) secretion through a corticotropin-releasing factor (CRF)-mediated mechanism. Brain Res 422:403-406
3. Sholar MB, Mendelson JH, Mello NK, Siegel AJ, Kaufman MJ, Levin JM, Renshaw PF, Cohen BM 1998 Concurrent pharmacokinetic analysis of plasma cocaine and adrenocorticotropic hormone in men. J Clin Endocrinol Metab 83:966-968
4. Sarnyai Z, Biro E, Penke B, Telegdy G 1992 The cocaine-induced elevation of plasma corticosterone is mediated by endogenous corticotropin-releasing factor (CRF) in rats. Brain Res 589:154-156
5. Teoh SK, Sarnyai Z, Mendelson JH, Mello NK, Springer SA, Sholar JW, Wapler M, Kuehnle JC, Gelles H 1994 Cocaine effects on pulsatile secretion of ACTH in men. J Pharmacol Exp Ther 270:1134-1138
6. Mendelson JH, Mello NK, Sholar MB, Siegel AJ, Mutschler N, Halpern J 2002 Temporal concordance of cocaine effects on mood states and neuroendocrine hormones. Psychoneuroendocrinology 27:71-82
7. Mendelson JH, Mello NK, Teoh SK, Lukas SE, Phipps W, Ellingboe J, Palmieri SL, Schiff I 1992 Human studies on the biological basis of reinforcement: a neuroendocrine perspective, in: O'Brien CP, Jaffe JH, eds. Addictive states. New York: Raven Press; 131-151
8. Goeders NE 1997 A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology 22:237-259
9. Goeders NE 2001 The HPA axis and cocaine reinforcement. Psychoneuroendocrinology 27:13-33
10. Mendelson JH, Sholar MB, Siegel AJ, Mello NK 2001 Effects of cocaine on luteinizing hormone in women during the follicular and luteal phases of the menstrual cycle and in men. J Pharmacol Exp Ther 296:972-979
11. Mello NK, Mendelson JH 1997 Cocaine's effects on neuroendocrine systems: clinical and preclinical studies. Pharmacol Biochem Behav 57:571-599
12. Delafuente JC, DeVane CL 1991 Immunologic effects of cocaine and related alkaloids. Immunopharmacol Immunotoxicol 13:11-23
13. Shen HM, Sha LX, Wiederhold MD, Ou DW 1995 Suppression of macrophage reactive intermediates by cocaine. Int J Immunopharmacol 17:419-423
14. Mao JT, Huang M, Wang J, Sharma S, Tashkin DP, Dubinett SM 1996 Cocaine down-regulates IL-2 induced peripheral blood lymphocyte IL-8 and IFN-γ production. Cell Immunol 172:217-223
15. Chaisson RE, Bacchetti P, Osmond D, Brodie B, Sande MA, Moss AR 1989 Cocaine use and HIV infection in intravenous drug users in San Francisco. JAMA 261:561-565
16. Chaisson MA, Stoneburner RL, Hildebrandt DS, Ewing WE, Telzak EE, Jaffe HW 1991 Heterosexual transmission of HIV-1 associated with the use of smokable freebase cocaine (crack). AIDS 5:1121-1126
17. Caiaffa WT, Vlahov D, Graham NM, Astemborski J, Solomon L, Nelson KE, Munoz A 1994 Drug smoking, Pneumocystis carnii pneumonia, and immunosuppression increase risk of bacterial pneumonia in human immunodeficiency virus-seropositive injection drug users. Am J Respir Crit Care Med 150:1493-1498
18. Turnbull AV, Rivier C 1995 Regulation of the HPA axis by cytokines. Brain Behav Immun 9:253-275
19. De Kloet ER, Oitzl MS, Schöbitz B 1994 Cytokines and the brain corticosteroid receptor balance: relevance to pathophysiology of neuroendocrine-immune communication. Psychoneuroendocrinology 19:121-134
20. Jones TH, Kennedy RL 1993 Cytokines and hypothalamic-pituitary function. Cytokine 5:531-538
21. Rivest S 2001 How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology 26:761-788
22. Chikanza IC, Grossman AB 2000 Reciprocal interactions between the neuroendocrine and immune systems during inflammation. Rheum Dis Clin North Am 26:693-711
23. Kronfol Z, Remick DG 2000 Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 157:683-694
24. Papanicolaou DA (moderator) 1998 The pathophysiologic roles of interleukin-6 in human disease. NIH Conference. Arm Intern Med 128:127-137
25. Hirano G, Akira S, Taga T, Kishimoto T 1990 Biological and clinical aspects of interleukin 6. Immunol Today 11:443-449
26. Wilder RL 1998 Interleukin-6 in autoimmune and inflammatory diseases. Ann Intern Med 128:130-132
27. Lyson K, McCann SM 1991 The effect of interleukin-6 on pituitary hormone release in vivo and in vitro. Neuroendocrinology 54:262-266
28. Zhou D, Kusnecov AW, Shurin MR, DePaoli M, Rabin BS 1993 Exposure to physical and psychological stressors elevates plasma intedeukin-6: relationship to the activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 133:2523-2530
29. Goebel MU, Mills PJ, Irwin MR, Ziegler MG 2000 Interleukin-6 and tumor necrosis factor-α after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways. Psychosom Med 62:591-598
30. Pedersen BK 2000 Special feature for the Olympics: effects of exercise on the immune system: exercise and cytokines. Immunol Cell Biol 78:532-535
31. Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM 2001 The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 15:43-58
32. + T cells by antigen-specific stimulation. Cell Immunol 164:57-64
33. Shen H-M, Kennedy JL, Ou DW 1994 Inhibition of cytokine release by cocaine. Int J Immunopharmacol 16:295-300
34. Chen G-J, Radhakrishna P, Erickson JR, Martinez F, Estrada AL, Watson RR 1991 Cocaine immunotoxicity: abnormal cytokine production in Hispanic drug users. Toxicol Lett 59:81-88
35. Gudmundsson A, Ershler WB, Goodman B, Lent SJ, Barczi S, Carnes M 1997 Serum concentrations of interleukin-6 are increased when sampled through an indwelling catheter. Clin Chem 43:2199-2201
36. Tallarida RJ, Murray RB 1991 Manual of pharmacologic calculations with computer programs, 2nd Ed. New York: Springer-Verlag
37. Lokensgard JR, Gekker G, Ehrlich LC, Hu S, Chao CC, Peterson PK 1997 Proinflammatory cytokines inhibit HIV-1sf162 expression in acutely infected human brain cell cultures. J Immunol 158:2449-2455
38. Fiala M, Stins MF, Gan X-H, Kermani V, Diagne A, Chappelli F, Kung MA, Martinez O, Way D, Graves M, Witte M, Shapshak P, Kim KS 1996 Abused drugs, cytokines, and the blood-brain barrier (BBB) in AIDS dementia. J Neuroimmunol 69:47-48
39. Baldwin GC, Tashkin DP, Buckley DM, Park AN, Dubinett SM, Roth MD 1997 Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am J Respir Crit Care Med 156:1606-1613
40. Papanicolaou DA, Tsigos C, Oldfield EH, Chrousos GP 1996 Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: does the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency? J Clin Endocrinol Metab 81:2303-2306
41. Crofford LJ, Kalogeras KT, Mastorakos G, Magiakou MA, Wells J, Kanik KS, Gold PW, Chrousos GP, Wilder RL 1997 Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab 82:1279-1283
42. Hagan P, Poole S, Bristow AF 1992 Immunosuppressive activity of corticotrophin-releasing factor. Biochem J 281:251-254
43. Wilder RL 1995 Neuroendocrine-immune system interactions and autoimmunity. Annu Rev Immunol 13:307-388
44. Hagan P, Poole S, Bristow AF 1992 Immunosuppressive activity of corticotrophin-releasing factor. Biochem J 281:251-254
45. Rohleder N, Kudielka BM, Helhammer DH, Wolf JM, Kirschbaum C 2002 Age and sex steroid-related changes in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress. J Neuroimmunol 126:69-77
46. Mello NK, Mendelson JH 2002 Cocaine, hormones and behavior: clinical and preclinical studies. In: Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE, Rubin RT, eds. Hormones, brain and behavior, vol 5. San Diego: Academic Press; 665-745
47. Mendelson JH, Mello NK, Sholar MB, Siegal AJ, Kaufman MJ, Levin JM, Renshaw PF, Cohen BM 1999 Cocaine pharmacokinetics in men and in women during the follicular and luteal phases of the menstrual cycle. Neuropsycho-pharmacology 21:294-303
48. Lansky A, Fleming PL, Byers RH, Karon JM, Wortley PM 2001 A method for classification of HIV exposure category for women without HIV risk information. MMWR 50:31-40