Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T cells

Human Gene Therapy

Volumn 14, Issue 4, 2003, Pages 341-351

  Kolen, Sebastianus ^a   Weijtens, Mo ^b   Hagenbeek, Anton ^b   Van Spronsen, Anke ^b   Smulders, Saskia ^b   De Weger, Roel ^b   De Witte, Theo ^a   Dolstra, Harry ^a   Van De Wiel Van Kemenade, Elly ^a   Martens, Anton ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GANCICLOVIR; GENOMIC DNA; MESSENGER RNA; RETROVIRUS VECTOR; THYMIDINE KINASE; VIRUS VECTOR;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENETIC TRANSDUCTION; GRAFT VERSUS HOST REACTION; HERPES SIMPLEX VIRUS; IMMUNOHISTOCHEMISTRY; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RAT; SUICIDE GENE; SUICIDE GENE THERAPY; T LYMPHOCYTE; VIRAL GENE THERAPY;

ANIMALS; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; GRAFT VS HOST DISEASE; IMMUNOMAGNETIC SEPARATION; MOLONEY MURINE LEUKEMIA VIRUS; RATS; RATS, INBRED BN; RECEPTOR, NERVE GROWTH FACTOR; SIMPLEXVIRUS; T-LYMPHOCYTES; THYMIDINE KINASE; TRANSDUCTION, GENETIC;

ANIMALIA; MOLONEY MURINE LEUKEMIA VIRUS; ONCOVIRINAE; SIMPLEXVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0037337917     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403321208943     Document Type: Article

References (33)

1. BONINI, C., FERRARI, G., VERZELETTI, S., SERVIDA, P., ZAPPONE, E., RUGGIERI, L., PONZONI, M., ROSSINI, S., MAVILIO, F., TRAVERSARI, C., and BORDIGNON, C. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724.
2. BORDIGNON, C., BONINI, C., VERZELETTI, S., NOBILI, N., MAGGIONI, D., TRAVERSARI, C., GIAVAZZI, R., SERVIDA, P., ZAPPONE, E., BENAZZI, E., BERNARDI, M., PORTA, F., FERRARI, G., MAVILIO, F., ROSSINI, S., BLAESE, R.F., and CANDOTTI, F. (1995). Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation. Hum. Gene Ther. 6, 813-819.
3. BORDIGNON, C., CARLO-STELLA, C., COLOMBO, M.P., DE VINCENTIIS, A., LANATA, L., LEMOLI, R.M., LOCATELLI, F., OLIVIERI A., RONDELLI, D., ZANON P., and TURA, S. (1999). Cell therapy: Achievements and perspectives. Haematologica 84, 1110-1149.
4. 1. Proc. Natl. Acad. Sci. U.S.A. 95, 12516-12521.
5. HEID, C.A., STEVENS, J., LIVAK, K.J., and WILLIAMS, P.M. (1996). Real time quantitative PCR. Genome Res. 6, 986-994.
6. HIGUCHI, R., FOCKLER, C., DOLLINGER, G., and WATSON, R. (1993). Kinetic PCR analysis: Real-time monitoring of DNA amplification reactions. Biotechnology 11, 1026-1030.
7. HOLLAND, P.M., ABRAMSON, R.D., WATSON, R., and GELFAND, D.H. (1991). Detection of specific polymerase chain reaction product by utilizing the 5′ → 3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 88, 7276-7280.
8. KERNAN, N.A., BARTSCH, G., ASH, R.C., BEATTY, P.G., CHAMPLIN, R., FILIPOVICH, A., GAJEWSKI, J., HANSEN, J.A., HENSLEE-DOWNEY, J., MCCULLOUGH, J., MCGLAVE, P., PERKINS, H.A., PHILLIPS, G.L., SANDERS, J., STRONCEK, D., THOMAS, E.D., and BLUME, K.G. (1993). Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N. Engl. J. Med. 328, 593-602.
9. KINSELLA, T.M., and NOLAN, G.P. (1996). Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7, 1405-1413.
10. KLOOSTERMAN, T.C., TIELEMANS, M.J., MARTENS, A.C., VAN BEKKUM, D.W., and HAGENBEEK, A. (1994). Quantitative studies on graft-versus-leukemia after allogeneic bone marrow transplantation in rat models for acute myelocytic and lymphocytic leukemia. Bone Marrow Transplant. 14, 15-22.
11. KLOOSTERMAN, T.C., MARTENS, A.C., VAN BEKKUM, D.W., and HAGENBEEK, A. (1995). Graft-versus-leukemia in rat MHC-mismatched bone marrow transplantation is merely an allogeneic effect. Bone Marrow Transplant. 15, 583-590.
12. LINK, C.J., JR., BURT, R.K., TRAYNOR, A.E., DROBYSKI, W.R., SEREGINA, T., LEVY, J.P., GORDON, L., ROSEN, S.T., BURNS, W.H., CAMITTA B., CASPER, J., HOROWITZ, M., JUCKETT, M., LAWTON, C., MARGOLIS, D., PIETRYGA, D., ROWLINGS, P., TAYLOR, C., FURTADO, M., STEFKA, J., GUPTA-BURT, S., KAISER, H., and VESOLE, D.H. (1998). Adoptive immunotherapy for leukemia: Donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103. Hum. Gene Ther. 9, 115-134.
13. LIVAK, K.J., FLOOD, S.J., MARMARO, J., GIUSTI, W., and DEETZ, K. (1995). Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods Appl. 4, 357-362.
14. LONG, Z., LU, P., GROOMS, T., MYCHKOVSKY, I., WESTLEY, T., FITZGERALD, T., SHARMA-CHIBBER, S., SHAND, N., MCGARRITY, G., and OTTO, E. (1999). Molecular evaluation of biopsy and autopsy specimens from patients receiving in vivo retroviral gene therapy. Hum. Gene Ther. 10, 733-740.
15. MADDENS, S., TIBERGHIEN, P., CONTASSOT, E., CERTOUX, J.M., CHALMERS, D., OTTO, E., HERVE, P., and FERRAND, C. (2000). Development of a competitive PCR method for in vitro and in vivo quantification of herpes simplex virus thymidine kinase and neomycin resistance-expressing cells used in a clinical trial. J. Hematother. Stem Cell Res. 9, 225-236.
16. MAURY, S., SALOMON B., KLATZMANN, D., and COHEN, J.L. (2001). Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice. Blood 98, 3156-3158.
17. PAQUIN, A., JAALOUK, D.E., and GALIPEAU, J. (2001). Retrovector encoding a green fluorescent protein-herpes simplex virus thymidine kinase fusion protein serves as a versatile suicide/reporter for cell and gene therapy applications. Hum. Gene Ther. 12, 13-23.
18. RANGA, U., WOFFENDIN, C., VERMA, S., XU, L., JUNE, C.H., BISHOP, D.K., and NABEL, G.J. (1998). Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals. Proc. Natl. Acad. Sci. U.S.A. 95, 1201-1206.
19. REIFFERS, J., GASPARD, M.H., MARANINCHI, D., MICHALLET, M., MARIT, G., STOPPA, A.M., CORRONT, B., DAVID, B., GASTAUT, J.A., SOTTO, J.J., BROUSET, A., CARCASONNE, Y., and HOLLARD, D. (1989). Comparison of allogeneic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukaemia in first remission: A prospective controlled trial. Br. J. Haematol. 72, 57-63.
20. RIDDELL, S.R., ELLIOTT, M., LEWINSOHN, D.A., GILBERT, M.J., WILSON, L., MANLEY, S.A., LUPTON, S.D., OVERELL, R.W., REYNOLDS, T.C., COREY, L., and GREENBERG, P.D. (1996). T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat. Med. 2, 216-223.
21. ROONEY, C.M., SMITH, C.A., NG, C.Y., LOFTIN, S., LI, C., KRANCE, R.A., BRENNER, M.K., and HESLOP, H.E. (1995). Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 345, 9-13.
22. ROSENBERG, S.A., AEBERSOLD, P., CORNETTA, K., KASID, A., MORGAN, R.A., MOEN, R., KARSON, E.M., LOTZE, M.T., YANG, J.C., TOPALIAN, S.L., MERINO, M.J., CULVER, K., MILLER., A.D., BLAESE, R.M., and ANDERSON, W.F. (1990). Gene transfer into humans - immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med. 323, 570-578.
23. SARGENT, T.D., YANG, M., and BONNER, J. (1981). Nucleotide sequence of cloned rat serum albumin messenger RNA. Proc. Natl. Acad. Sci. U.S.A. 78, 243-246.
24. SEROOGY, C.M., and FATHMAN, C.G. (2000). The application of gene therapy in autoimmune diseases. Gene Ther. 7, 9-13.
25. SYKES, M. (1993). Novel approaches to the control of graft versus host disease. Curr. Opin. Immunol. 5, 774-781.
26. TAN, R., XU, X., OGG, G.S., HANSASUTA, P., DONG, T., ROSTRON, T., LUZZI, G., CONLON, C.P., SCREATON, G.R., MCMICHAEL, A.J., and ROWLAND-JONES, S. (1999). Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome. Blood 93, 1506-1510.
27. TIBERGHIEN, P., CAHN, J.Y., BRION, A., DECONINCK, E., RACADOT, E., HERVE, P., MILPIED, N., LIOURE, B., GLUCKMAN, E., BORDIGONI, P., JACOB, W., CHIANG, Y., MARCUS, S., REYNOLDS, C., and LONGO, D. (1997). Use of donor T-lymphocytes expressing herpes-simplex thymidine kinase in allogeneic bone marrow transplantation: A phase I-II study. Hum. Gene Ther. 8, 615-624.
28. TIBERGHIEN, P., FERRAND, C., LIOURE, B., MILPIED, N., ANGONIN, R., DECONINCK, E., CERTOUX, J.M., ROBINET, E., SAAS, P., PETRACCA, B., JUTTNER, C., REYNOLDS, C.W., LONGO, D.L., HERVE, P., and CAHN, J.Y. (2001). Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97, 63-72.
29. VERZELETTI, S., BONINI, C., MARKTEL, S., NOBILI, N., CICERI, F., TRAVERSARI, C., and BORDIGNON, C. (1998). Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors. Hum. Gene Ther. 9, 2243-2251.
30. VOGELSANG, G.B., and HESS, A.D. (1994) Graft-versus-host disease: New directions for a persistent problem. Blood 84, 2061-2067.
31. WEIJTENS, M.E., WILLEMSEN, R.A., HART, E.H., and BOLHUIS, R.L. (1998). A retroviral vector system "STITCH" in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes. Gene Ther. 5, 1195-1203.
32. WEIJTENS, M.E, VAN SPRONSEN, A., HAGENBEEK, A., BRAAKMAN, E., and MARTENS, A.C.M. (2002). Reduced graft-versus-host disease-inducing capacity of T cells after activation, culturing, and magnetic cell sorting selection in an allogeneic bone marrow transplantation model in rats. Hum. Gene Ther. 13, 187-198.
33. WONG-STAAL, F., POESCHLA, E.M., and LOONEY, D.J. (1998). A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum. Gene Ther. 9, 2407-2425.