The application of gene therapy in autoimmune diseases

Gene Therapy

Volumn 7, Issue 1, 2000, Pages 9-13

  Seroogy, C M ^a   Fathman, C G ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune disease; CD4+ T cell; Gene therapy

Indexed keywords

CD4 ANTIGEN; REGULATOR PROTEIN; VIRUS VECTOR;

ADOPTIVE IMMUNOTHERAPY; AUTOIMMUNE DISEASE; CLINICAL TRIAL; GENE THERAPY; GENETIC TRANSDUCTION; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RETROVIRUS; SHORT SURVEY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

UNIDENTIFIED RETROVIRUS;

EID: 0033977644     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301111     Document Type: Short Survey

References (35)

1. Evans CH et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996; 7: 1261-1280.
2. Linington C et al. Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody. J Neuroimmunol 1992; 40: 219-224.
3. Kakimoto K et al. Isolation of T cell line capable of protecting mice against collagen-induced arthritis. J Immunol 1988; 140: 78-83.
4. Almawi WY, Tamim H, Azar ST. Clinical review 103: T helper type 1 and 2 cytokines mediate the onset and progression of type I (insulin-dependent) diabetes. Clin Endocrinol Metab 1999; 84: 1497-1502.
5. Calabresi PA et al. Cytokine gene expression in cells derived from CSF of multiple sclerosis. J Neuroimmunol 1998; 89: 198-205.
6. Skapenko A et al. Altered memory T cell differentiation in patients with early rheumatoid arthritis. J Immunol 1999; 163: 491-499.
7. + T cells in the pathogenesis of organ-specific autoimmune diseases (see comments). Immunol Today 1995; 16: 34-38.
8. Khoury SJ, Hancock WW, Weiner HL. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 1992; 176: 1355-1364.
9. Begolka WS et al. Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis. J Immunol 1998; 161: 4437-4446.
10. Mauri C et al. Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur J Immunol 1996; 26: 1511-1518.
11. Ouyang W et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 1998; 9: 745-755.
12. Swain SL. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity 1994; 1: 543-552.
13. Bradley LM, Yoshimoto K, Swain SL. The cytokines I1-4, IFN-gamma and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J Immunol 1995; 155: 1713-1724.
14. Brocke S et al. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 1996; 379: 343-346.
15. Chen Y et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237-1240.
16. Bergerot I et al. Active suppression of diabetes after oral administration of insulin is determined by antigen dosage. Ann NY Acad Sci 1996; 778: 362-367.
17. Nagler-Anderson C et al. Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc Natl Acad Sci USA 1986; 83: 7443-7446.
18. Thompson HS, Staines NA. Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats. Clin Exp Immunol 1986; 64: 581-586.
19. Wang ZY et al. Suppression of experimental autoimmune myasthenia gravis and experimental allergic encephalomyelitis by oral administration of acetylcholine receptor and myelin basic protein: double tolerance. J Neuroimmunol 1995; 63: 79-86.
20. Hafler DA et al. Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Ann NY Acad Sci 1997; 835: 120-131.
21. Trentham DE et al. Effects of oral administration of type II collagen on rheumatoid arthritis (see comments). Science 1993; 261: 1727-1730.
22. McKown KM et al. Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis. Arth Rheum 1999; 42: 1204-1208.
23. Bonini C et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia (see comments). Science 1997; 276: 1719-1724.
24. Anderson WF, McGarrity GJ, Moen RC. Report to the NIH Recombinant DNA Advisory Committee on murine replication-competent retrovirus (RCR) assays (February 17, 1993). Hum Gene Ther 1993; 4: 311-321.
25. Powell SK et al. In vitro analysis of transformation potential associated with retroviral vector insertions. Hum Gene Ther 1999; 10: 2123-2132.
26. Mathisen PM et al. Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J Exp Med 1997; 186: 159-164.
27. Shaw MK et al. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J Exp Med 1997; 185: 1711-1714.
28. Kuchroo VK et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995; 80: 707-718.
29. Chen LZ et al. Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1. Proc Natl Acad Sci USA 1998; 95: 12516-12521.
30. Moritani M et al. Prevention of adoptively transferred diabetes in nonobese diabetes with IL-10-transduced islet-specific Th1 lymphocytes. J Clin Invest 1996; 98: 1851-1859.
31. Moritani M et al. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int Immunol 1994; 6: 1927-1936.
32. Wogensen L, Lee MS, Sarvetnick N. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice. J Exp Med 1994; 179: 1379-1384.
33. Costa G et al. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. J Immunol (submitted).
34. + T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Med 1999; 5: 843-847.
35. Kashara N, Dozy AM, Kan YW. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions (see comments). Science 1994; 266: 1373-1376.