Reduced graft-versus-host disease-inducing capacity of T cells after activation, culturing, and magnetic cell sorting selection in an allogeneic bone marrow transplantation model in rats

Human Gene Therapy

Volumn 13, Issue 2, 2002, Pages 187-198

  Weijtens, Mo ^a   Van Spronsen, Anke ^a   Hagenbeek, Anton ^a   Braakman, Eric ^b   Martens, Anton ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RECURRENCE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; DRUG EFFECT; GENETIC TRANSDUCTION; GRAFT VERSUS HOST REACTION; HERPES SIMPLEX VIRUS; LEUKEMIA; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; MALE; NONHUMAN; RAT; SUICIDE GENE; SURVIVAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; BODY WEIGHT; BONE MARROW TRANSPLANTATION; CELL CULTURE TECHNIQUES; CELL LINE; DISEASE MODELS, ANIMAL; GANCICLOVIR; GRAFT VS HOST DISEASE; IMMUNOMAGNETIC SEPARATION; LYMPHOCYTE ACTIVATION; RATS; RATS, INBRED BN; SIMPLEXVIRUS; T-LYMPHOCYTES; THYMIDINE KINASE; TRANSDUCTION, GENETIC;

ANIMALIA; SIMPLEXVIRUS;

EID: 0036170566     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340252769725     Document Type: Article

References (40)

1. Mechanisms of the graft-versus-leukemia reaction
2. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia
3. Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation
4. Immunobiology of bone marrow transplantation as treatment for hematologic malignancies
5. Prevention of graft-versus-host disease in mice using a suicide gene expressed in T lymphocytes
6. In vivo alloreactive potential of ex vivo-expanded primary T lymphocytes
7. Ganciclovir-sensitive acute graft-versus-host disease in mice receiving herpes simplex virus-thymidine kinase-expressing donor T cells in a bone marrow transplantation setting
8. Ex vivo anti-CD3 antibody-activated donor T cells have a reduced ability to cause lethal murine graft-versus-host disease but retain their ability to facilitate alloengraftment
9. Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene
10. Retrovirus-mediated gene transfer in primary T lymphocytes: Influence of the transduction/selection process and of ex vivo expansion on the T cell receptor beta chain hypervariable region repertoire
11. Graft-versus-host disease
12. Mechanisms of lymphocyte traffic and cell targeting
13. Migration of activated lymphocytes
14. Graft-versus-leukemia reactions after bone marrow transplantation
15. Human gene transfer: Characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man
16. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
17. Quantitative studies on graft-versus-leukemia after allogeneic bone marrow transplantation in rat models for acute myelocytic and lymphocytic leukemia
18. Preemptive control of graft-versus-host disease in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes
19. Inhibition of graft-versus-host disease. Use of a T cell-controlled suicide gene
20. Adoptive immunotherapy for leukemia: Donor lymphocytes transduced with the herpes simplex thymidine kinase gene for remission induction. HGTRI 0103
21. Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset composition
22. T-cell depletion of HLA-identical transplants in leukemia
23. BN acute myelocytic leukemia (BNML). A rat model for studying human acute leukemia (AML)
24. The role of donor lymphoid cells in allogeneic marrow engraftment
25. Peripheral blood lymphocytes as target of retroviral vector-mediated gene transfer
26. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
27. Retrovirus-mediated gene transfer into T cells: 95% Transduction efficiency without further in vitro selection
28. High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragment
29. The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells
30. The role of adhesion and costimulation molecules in graft-versus-host disease
31. Evaluation of membrane physiology following fluorescence activated or magnetic cell separation
32. Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information
33. IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity
34. Allorecognition and graft-versus-host disease
35. Use of donor T-lymphocytes expressing herpes-simplex thymidine kinase in allogeneic bone marrow transplantation: A phase I-II study
36. Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: An approach for specific in vivo donor T-cell depletion after bone marrow transplantation?
37. Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
38. Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow
39. Herpes simplex virus thymidine kinase transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors
40. A retroviral vector system STITCH in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes