Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: Identification, molecular cloning and effects on cell migration

Biochemical Journal

Volumn 370, Issue 2, 2003, Pages 537-549

  Zannettino, Andrew C W ^a   Roubelakis, Maria ^b,c   Welldon, Katie J ^a   Jackson, Denise E ^a   Simmons, Paul J ^d   Benball, Linda J ^e   Henniker, Anthony ^e   Harrison, Kate L ^a   Niutta, Silvana ^a   Brabstock, Kenneth F ^e   Watt, Suzanne M ^b  

^a HANSON INSTITUTE   (Australia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

CD34+; Genomic structure; Immunoglobulin superfamily; Src homology phosphatase (SHP); Stem cells

Indexed keywords

CELLS; CLONING; GENES; MONOCLONAL ANTIBODIES;

MOLECULAR CLONING;

BIOCHEMISTRY;

CD34 ANTIGEN; CD38 ANTIGEN; GLYCOPROTEIN; ISOPROTEIN; MONOCLONAL ANTIBODY; TYROSINE;

ARTICLE; CELL MIGRATION; CHROMOSOME 1Q; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENDOTHELIUM CELL; FIBROBLAST; GENETIC TRANSCRIPTION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MESENCHYME CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; STEM CELL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CARRIER PROTEINS; CELL MOVEMENT; ENDOTHELIUM; HEMATOPOIETIC STEM CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; MESODERM; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN ISOFORMS; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 0037335855     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020935     Document Type: Article

References (45)

1. Fauman, E. B. and Saper, M. A. (1996) Structure and function of the protein tyrosine phosphatases. Trends Biochem. Sci. 21, 413-417
2. Oh, E. S., Gu, H., Saxton, T. M., Timms, J. F., Hausdorff, S., Frevert, E. U., Kahn, B. B., Pawson, T., Neel, B. G. and Thomas, S. M. (1999) Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol. Cell. Biol. 19, 3205-3215
3. Tonks, N. K. and Neel, B. G. (1996) From form to function: signalling by protein tyrosine phosphatases. Cell (Cambridge, Mass.) 87, 365-368
4. Huyer, G. and Alexander, D. R. (1999) Immune signalling: SHP-2 docks at multiple ports. Curr. Biol. 9, R129-R132
5. Klingmuller, U. (1997) The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells - signals emanating from the erythropoietin receptor. Eur. J. Biochem. 249, 637-647
6. Qu, C. K., Shi, Z. Q., Shen, R., Tsai, F. Y., Orkin, S. H. and Feng, G. S. (1997) A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol. Cell. Biol. 17, 5499-5507
7. Kim, C. H., Qu, C. K., Hangoc, G., Cooper, S., Anzai, N., Feng, G. S. and Broxmeyer, H. E. (1999) Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphalase SHP-1 in chemokine responses. J. Exp. Med. 190, 681-690
8. Frearson, J. A. and Alexander, D. R. (1997) The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction. BioEssays 15, 414-427
9. Yokoyama, W. M. (1997) What goes up must come down: the emerging spectrum of inhibitory receptors. J. Exp. Med. 186, 1803-1808
10. Frearson, J. A. and Alexander, D. R. (1998) The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J. Exp. Med. 187, 1417-1426
11. Feng, G. S. (1999) Shp-2 tyrosine phosphatase: signaling one cell or many. Exp. Cell. Res. 253, 47-54
12. Plas, D. R. and Thomas, M. L. (1998) Negative regulation of antigen receptor signaling in lymphocytes. J. Mol. Med. 76, 589-595
13. Saxton, T. M., Henkemeyer, M., Gasca, S., Shen, R., Rossi, D. J., Shalaby, F., Feng, G. S. and Pawson, T. (1997) Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 16, 2352-2364
14. 2-terminal mitogen-activated protein kinases. J. Biol. Chem. 273, 4904-4908
15. Raabe, T., Riesgo-Escovar, J., Liu, X., Bausenwein, B. S., Deak, P., Maroy, P. and Hafen, E. (1996) DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell (Cambridge, Mass.) 85, 911-920
16. Vivier, E. and Daeron, M. (1997) Immunoreceptor tyrosine-based inhibition motifs. Immunol. Today 18, 286-291
17. Zhao, Z. J. and Zhao, R. (1998) Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2. J. Biol. Chem. 273, 29367-29372
18. Zhao, R. and Zhao, Z. J. (2000) Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. J. Biol. Chem. 275, 5453-5459
19. Chan, J. Y., Prudhoe, J. E., Jorgensen, B., Doyonnas, R., Zannettino, A. C. W., Buckle, V. J., Ward, C. J., Simmons, P. J. and Watt, S. M. (2001) Relationship between novel isoforms, functionally important domains, and subcellular distribution of novel CD164/endolyn. Blood 276, 2139-2152
20. Watt, S. M., Bulter, L., Tavian, M., Burhing, H.-J., Rapppold, I., Simmons, P. J., Zannettino, A. C. W., Buck, D., Fuchs, A., Doyonnas, R. et al. (2000) Functionally defined CD164 epitopes are expressed on CD34+ cells throughout onogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues. Blood 95, 3113-3124
21. Watt, S. M., Buhring, H. J., Rappold, I., Chan, J. Y., Lee-Prudhoe, J., Jones, T., Zannettino, A. C., Simmons, P. J., Diyonnas, R., Sheer, D. and Bulter, L. H. (1998) CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Blood 92, 849-866
22. Ford, A. M., Watt, S. M., Furley, A. J., Molgaard, H. V. and Greaves, M. F. (1988) Cell lineage specificity of chromatin configuration around the immunoglobulin heavy chain enhancer. EMBO J. 7, 2393-2399
23. Zannettino, A. C. W., Buhring, H.-J., Niutta, S., Watt, S. M., Benton, M. A. and Simmons, P. J. (1998) The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as potential negative regulator of hematopoiesis. Blood 92, 2613-2628
24. Simmons, P. J., Przepiorka, D., Thomas, E. D. and Torok-Storb, B. (1987) Host origin of marrow stromal cells following allogeneic bone marrow transplantation. Nature (London) 328, 429-432
25. Haylock, D. N., To, L. B., Dowse, T. L., Jutter, C. A. and Simmons, P. J. (1992) Ex-vivo expansion and maturation of peripheral blood CD34+ cells into myeloid lineage. Blood 80, 1405-1412
26. Cole, S. R., Ashman, L. K. and Ey, P. L. (1987) Biotinylation: an alternative to radioiodination for the identification of cell surface antigens in immunoprecipitates. Mol. Immunol. 24, 699-705
27. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680-685
28. Zannettino, A. C. W., Rayner, J. R., Ashman, L. K. G. T. J. and Simmons, P. J. (1996) A powerfull new technique for isolating genes encoding cell surface antigen using retroviral expression cloning. J. Immunol. 156, 611-620
29. Chiu, R. W., Murphy, M. F., Fidler, C., Wainscoat, J. S. and Lo, Y. M. (2001) Technical optimization of RhD zygosity determination by real-time quantitative polymerase chain reaction: implication for fetal RhD status determination by maternal plasma. Ann. N. Y. Acad. Sci. 945, 156-160
30. Yu, D. H., Qu, C. K., Henegariu, O., Lu, X. and Feng, G. S. (1998) Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273, 21125-21131
31. Zhao, R., Guerrah, A., Tang, H. and Zhao, Z. J. (2001) Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling. J. Biol. Chem. 277, 7882-7888
32. Fournier, N., Chalus, L., Durand, I., Garcia, E., Pin, J. J., Churakova, T., Patel, S., Zlot, C., Gorman, D., Zurawski, S. et al. (2000) FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J. Immunol. 165, 1197-1209
33. Xu, M., Zhao, R., Sui, X., Xu, F. and Zhao, Z. J. (2000) Tyrosine phosphorylation of myelin P(0) and its implication in signal transduction. Biochem. Biophys. Res. Commun. 267, 820-825
34. Xu, W., Shy, M., Kamholz, J., Elferink, L., Xu, G., Lilien, J. and Balsamo, J. (2001) Mutations in the cytoplasmic domain of P0 reveal a role for PKC- mediated phosphorylation in adhesion and myelination. J. Cell. Biol. 155, 439-446
35. 2-terminal kinase activation in B cells. J. Immunol. 165, 1344-1351
36. Qu, C. K., Yu, W. M., Azzarelli, B., Cooper, S., Broxmeyer, H. E. and Feng, G. S. (1998) Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol. Cell. Biol. 18, 6075-6082
37. Burdon, T., Stracey, C., Chambers, I., Nichols, J. and Smith, A. (1999) Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 210, 30-43
38. Yu, C., Jin, Y. and Burakoff, S. (2000) Cytosolic tyrosine dephosphorylation of STATS potential role of SHP-2 in STAT-5 regulation. J. Biol. Chem. 275, 599-604
39. Tang, T. L., Freeman, R. M. Jr, O'Reilly, A. M., Neel, B. G. and Sokol, S. Y. (1995) The SH2-containing protein-tyrosine phosphatase SH-PTP2 is iequired upstream of MAP kinase for early Xenopus development. Cell (Cambridge, Mass.) 80, 473-483
40. Kharitonenkov, A., Chen, Z., Sures, I., Wang, H., Schilling, J. and Ullrich, A. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature (London) 386, 181-186
41. Fujioka, Y., Matozaki, T., Noguchi, T., Iwamatsu, A., Yamao, T., Takahashi, N., Tsuda, M., Takada, T. and Kasuga, M. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16, 6887-6899
42. Seiffert, M., Brossart, P., Cant, C., Cella, M., Colonna, M., Brugger, W., Kanz, L., Ullrich, A. and Buhring, H. J. (2001) Signal-regulatory protein α (SIRPα) but not SIRPβ is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells. Blood 97, 2741-2749
43. Tomasello, E., Cant, C., Buhring, H. J., Vely, F., Andre, P., Seiffert, M., Ullrich, A. and Vivier, E. (2000) Association of signal-regulatory proteins β with KARAP/DAP-12. Eur. J. Immunol. 30, 2147-2156
44. Takada, T., Matozaki, T., Takeda, H., Fukunaga, K., Noguchi, T., Fujioka, Y., Okazaki, I., Tsuda, M., Yamao, T., Ochi, F. and Kasuga, M. (1998) Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. J. Biol. Chem. 273, 9234-9242
45. Tomasello, E., Olcese, L., Vely, F., Geourgeon, C., Blery, M., Moqrich, A., Gautheret, D., Djabali, M., Mattei, M. G. and Vivier, E. (1998) Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12. J. Biol. Chem. 273, 34115-34119