A link between c-Myc-mediated transcriptional repression and neoplastic transformation

Journal of Clinical Investigation

Volumn 97, Issue 7, 1996, Pages 1687-1695

  Lee, Linda A ^a   Dolde, Christine ^a   Barrett, John ^a   Wu, Chyi S ^a   Dang, Chi V ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

basic helix loop helix; bHLH; Burkitt lymphoma; transrepression

Indexed keywords

CIS ACTING ELEMENT; ONCOPROTEIN; PHENYLALANINE; TRANSCRIPTION FACTOR;

ADENOVIRUS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; FIBROBLAST; GENETIC TRANSCRIPTION; LYMPHOMA; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; RAT; START CODON; TRANSACTIVATION;

EID: 0029912395     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118595     Document Type: Article

References (56)

1. Kato, G J , and C.V. Dang. 1992 Function of the c-Myc oncoprotein. FASEB J. 6 3065-3072.
2. Kato, G.J., J. Barrett, M. Villa-Garcia, and C.V. Dang 1990. An amino terminal c-myc domain required for neoplastic transformation activates transcription. Mol. Cell. Biol. 10:5914-5920.
3. Dang, C.V , J Barrett, M. Villa-Garcia, L M.S. Resar, G.J. Kato, and E.R. Fearon. 1991. Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization. Mol. Cell. Biol. 11.954-962.
4. Prendergast, G.C., D. Lawe, and E B. Ziff. 1991. Association of Myn. the murine homolog of Max with c-myc stimulates methylation-sensitive DNA-binding and ras cotransformation. Cell. 65:395-407
5. Stone, J., T. de Lange, G. Ramsay, E. Jokobovits, J.M. Bishop, H.E. Varmus, and W.M.F. Lee. 1987. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell. Biol 7:1697-1709.
6. Sarid, J., T.D. Halazonetis, W. Murphy, and P. Leder. 1987. Evolutionary conserved regions of the human c-Myc protein can be uncoupled from transforming activity. Proc. Natl. Acad. Sci. USA. 84:170-173.
7. Amati, B., M.W. Brooks, N. Levy, T.D. Littlewood, G.I. Evan, and H. Land 1993. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell. 72:233-245.
8. Blackwell, T.K., J. Huang, A. Ma, L. Kretzner, F.W. Alt, R.N. Eisenman, and H. Weintraub. 1993 Binding of Myc proteins to canonical and noncanonical DNA sequences. Mol. Cell. Biol. 13:5216-5224.
9. Blackwood, E.M., and R.N. Eisenman. 1991. Max. a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science (Wash. DC). 251:1211-1217.
10. Reddy, C.D., P. Dasgupta, P. Saikumar, H. Dudek, F.J. Rauscher III, and E.P. Reddy. 1992. Mutational analysis of Max: role of basic, helix-loop-helix/leucine zipper domains in DNA binding, dimerization and regulation of Myc-mediated transcriptional activation. Oncogene. 7:2085-2092.
11. Kretzner, L., E.M. Blackwood, and R.N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature (Lond ). 359:426-429.
12. Gu, W., K. Cechova, V. Tassi, and R. Dalla-Favera. 1993. Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc. Natl Acad. Sci USA. 90:2935-2939.
13. Amin, C., A. Wagner, and N. Hay. 1993. Sequence-specific transcriptional activation by Myc and repression by Max. Mol Cell. Biol 13:383-390.
14. Bello-Femandez, C., G. Packham, and J.L Cleveland. 1993. The ornithinc decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. USA. 90:7804-7808.
15. Berberich, S., N. Hyde-DeRuyscher, P Espenshade, and M. Cole. 1992. Max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. Oncogene. 7:775-779.
16. Kato, G.J., W.M.F. Lee, L. Chen, and C.V. Dang. 1992. Max: functional domains and interaction with c-Myc. Genes Dev. 6:81-92.
17. Ayer, D.E., L. Kretzner, and R.N. Eisenman. 1993 Mad: a heterodimeric partner for Max that antagonizes Myc transeriptional activity. Cell. 72:211-222.
18. Zervos, A., J. Gyuris, and R. Brent. 1993. Mxil, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell. 72:223-232.
19. Lahoz, E.G , L. Xu, N. Schreiber-Agus, and R.A DePinho. 1994. Suppression of Myc but not E1A transformation activity by Max-associated proteins. Mad and Mxi-1. Proc Natl. Acad. Sci. USA. 91:5503-5507.
20. Schreiber-Agus, N., R. Torres, J. Horner, A. Lau, M. Jamnch, and R.A. DePinho 1993 Comparative analysis of the expression and oncogenic activities of Xenopus c-. N-. and L-myc homologs. Mol. Cell Biol. 13:2456-2468.
21. Blackwood, E.M., B. Luscher, and R.N. Eisenman. 1992 Myc and Max associate in vivo. Genes Dev. 6:71-80.
22. Wagner, A., M.M. Le Beau, M.O. Diaz, and N Hay. 1992. Expression, regulation and chromosomal localization of the Max gene. Proc. Natl. Acad Sci USA. 89:3111-3115.
23. Ayer, D.E , and R.N. Eisenman. 1993. A switch from Myc-Max to Mad: Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7:2110-2119.
24. Maheswaran, S., H. Lee, and G. Sonenshein. 1994 Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein. Mol. Cell. Biol. 14:1147-1152.
25. Hateboer, G., H.T.M. Timmers, A.K. Rustgi, M. Billaud, L.J. van't Veer, and R. Bernards. 1993. TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein Proc. Natl. Acad. Sci. USA. 90:8489-8493
26. Beijersbergen, R.L , E.M. Hijmans, and R. Bernards. 1994. Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO (Eur Mol. Biol. Organ.) J. 13:4080-4086.
27. Shrivastava, A., S. Saleque, G.V. Kalpana, S. Artandi, S.P. Goff, and K. Calame. 1993. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science (Wash DC). 262.1889-1892.
28. Roy, A.L., C. Carruthers, T. Gutjahr, and R.G. Roeder. 1993. Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature (Lond.). 365.359-361.
29. Van Antwerp, M.E., D.G Chen, C. Chang, and E V. Prochownik. 1992. A point mutation in the MyoD basic domain imparts c-Myc-like properties. Proc. Natl. Acad. Sci. USA. 89:9010-9014.
30. Kaddurah-Daouk, R., J.M. Greene, A.S. Baldwin, Jr., and R.E. Kingston. 1987. Activation and repression of mammalian gene expression by the c-myc protein. Genes Dev. 1:347-357.
31. Lee, L.A., L M.S. Resar, and C.V Dang. 1994 Cell density and paradoxical transcriptional properties of c-Myc and Max in cultured mouse fibroblasts. J. Clin. Invest. 95:900-904.
32. Roy, B., J. Beamon, F., Balint, and D. Reisman. 1994. Transactivatton of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors. Mol. Cell Biol. 14:7805-7815.
33. Yang, B.-S., T.J. Geddes, R.J. Pogulis, B. de Crombrugghe, and S.O. Freytag. 1991. Transcriptional suppression of cellular gene expression by c-Myc Mol. Cell. Biol. 11.2291-2295.
34. Jansen-Durr, P., A. Mcichle, P. Steiner, M. Pagano, D. Finke, J. Botz, J. Wessbechcr, G. Draetta, and M. Eilers. 1993. Differential modulation of cyclin gene expression by MYC. Proc Natl. Acad Sci. USA. 90:3685-3689.
35. Corden, J., B Wasylyk, A. Buchwalder, P. Sassone-Corsi, C. Kedinger, and P. Chambon. 1980. Promoter sequences of eukaryotic protein-encoding genes. Science (Wash. DC). 209:1405-1414.
36. Smale, S.T., and D. Baltimore. 1989. The "initiator" as a transcription control element Cell 57:103-113.
37. Li, L.-H., C. Nerlov, G. Prendergast, D. MacGregor, and E.B. Ziff. 1994 c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box O. EMBO (Eur. Mol. Biol. Organ.) J. 13. 4070-4079.
38. Philipp, A., A. Schneider, I. Vasrik, K. Finke, Y. Xiong, D. Beach, K. Alitalo, and M. Eilers. 1994. Repression of cyclin D1: a novel function of myc. Mol. Cell. Biol. 14:4032-4043.
39. Mai, S., and I.-L. Mårtensson. 1995. The c-myc protein represses λ5 and TdT initiators. Nucleic Acids Res. 23 1-9.
40. Clark, H.M., T. Yano, T. Otsuki, E.S. Jaffe, D. Shibata, and M. Raffeld. 1994. Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas. Cancer Res. 54:3383-3386.
41. Ausabel, F.M., R. Brent R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1987. Introduction of DNA into mammalian cells. In Current Protocols in Molecular Biology. Vol. 1. John Wiley & Sons Inc., New York. 9.0.1-9.5.5.
42. Seed, B., and J.Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene. 67:271-277.
43. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254.
44. Hoang, A.T., K.J. Cohen, J.F. Barrett, D.A. Bergstrom, and C.V. Dang. 1994. Participation of cyclin A in Myc-induced apoptosis. Proc. Natl. Acad. Sci. USA 91:6875-6879.
45. Laemmli, U K 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature (Lond.) 227:680-685.
46. Evan, G.I., G.K. Lewis, G. Ransay, and J.M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell. Biol. 5:3610-3616.
47. Roy, A.L., M. Meisterernst, P Pogenec, and R.G. Roeder. 1991. Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF Nature (Lond ). 354:245-248.
48. Du, H., A.L. Roy, and R.G. Roeder. 1993. Human transcription factor USF stimulates transcription through the initiator element of the HIV-1 and the adML promoters. EMBO (Eur. Mol. Biol Organ.) J. 12:501-511.
49. Bhatia, K., K. Huppi, G. Spangler, D Siwarski, R. Iyer, and I. Magrath. 1993. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytoma. Nat. Genet. 5:56-61.
50. Yano, T , C. Sander, H. Clark, M. Dolezal, E. Jaffe, and M. Raffeld. 1993. Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma. Oncogene. 8:2741-2748.
51. Gu, W., K. Bhatia, I.T. Magrath, C.V. Dang, and R. Dalla-Favera. 1994. Binding and suppression of the Myc transcriptional activation domain by p107. Science (Wash. DC). 264:251-254.
52. Hoang, A., B. Lutterbach, B C Lewis, T. Yano, T. Chou, J. Barrett, M. Raffeld, S.R. Hann and C.V. Dang. 1995. A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol. Cell. Biol. 15:4031-4042.
53. Dang, C.V., M. McGuire, M. Buckmire, and W.M.F. Lee. 1989. Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein. Nature (Lond.). 337:664-666.
54. Usheva, A., and T. Shenk 1994 TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA Cell. 76:1115-1121.
55. Mukherjee, B., S D. Morgenbesser, and R.A. DePinho. 1992. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes Dev. 6.1480-1492.
56. Eilers, M., S. Schirm, and J.M. Bishop 1991. The MYC protein activates transcription of the alpha-prothymosin gene EMBO (Eur. Mol. Biol. Organ.) J 10:133-141.