Antiallodynic effects of a CCK(B) antagonist in rats with nerve ligation injury: Role of endogenous enkephalins

Neuroscience Letters

Volumn 215, Issue 3, 1996, Pages 161-164

  Nichols, Michael L ^a   Bian, Di ^a   Ossipov, Michael H ^a   Malan Jr , T Philip ^a   Porreca, Frank ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Allodynia; Antisera; Cholecystokinin; Na ltrindole; Nerve injury; Neuropathic pain; Thiorphan; Leu5 enkephalin

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; ENKEPHALIN; NALTRINDOLE; OPIATE ANTAGONIST; THIORPHAN; CHOLECYSTOKININ RECEPTOR; DRUG DERIVATIVE; NALTREXONE; NARCOTIC ANTAGONIST;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRATHECAL DRUG ADMINISTRATION; MALE; NERVE LIGATION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; PAIN; PERIPHERAL NERVOUS SYSTEM; SPRAGUE DAWLEY RAT;

ANIMALS; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; PAIN; PERIPHERAL NERVOUS SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHOLECYSTOKININ; THIORPHAN;

EID: 85047675957     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12964-5     Document Type: Article

References (29)

1. [1] Amer, S. and Meyerson, B.A., Lack of analgesic effect on neuropathic and idiopathic forms of pain. Pain, 33 (1988) 11-23.
2. [2] Arvidsson, U., Dado, R.J., Riedl, M., Lee, J.-H., Law, P.J., Loh, H.H., Elde, R. and Wessondorf, M.W., δ Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J. Neurosci., 15 (1995) 1215-1235.
3. [3] Besse, D., Lombard, M.C., Zajac, J.M., Roques, B.P. and Besson, J.M., Pre-and post-synaptic distribution of μ. κ and δ opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord, Brain Res., 521 (1990) 15-22.
4. [4] Chaillet, P., Marcais-Collado, H., Costentin, J., Yi, C.-C., De La Baume, S. and Schwartz, J.-C., Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an amino peptidase inhibitor. Eur. J. Pharmacol., 86 (1983) 329-336.
5. [5] Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M. and Yaksh, T.L., Quantitative assessment of tactile allodynia in the rat paw, J. Neurosci. Methods, 53 (1994) 55-63.
6. [6] Dado, R.J., Law, P.Y., Loh, H.H. and Elde, R., Immunoflourescent identification of a delta opioid receptor on primary afferent nerve terminals, NeuroReport, 5 (1993) 341-344.
7. B-receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat, Eur. J. Pharmacol., 176 (1990) 35-44.
8. [8] Evans, D.A. and Mathre, D.J., Asymmetric synthesis of the enkephalinase inhibitor thiorphan, J. Org. Chem., 50 (1985) 1830-1835.
9. [9] Faris, P.L., Komisaruk, B.R., Watkins, L.R. and Mayer, D.J., Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia. Science, 219 (1983) 310-312.
10. [10] Hughes, J., Hunter, J.C. and Woodruff, G.N., Neurochemical actions of CCK underlying the therapeutic potential of CCK-B antagonists, Neuropeptides, 19 (1991) 85-89.
11. [11] Kim, S.H. and Chung, J.M., An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain, 50 (1992) 355-363.
12. [12] Nichols, M.L., Bian, D., Ossipov, M.H., Lai, J. and Porreca, F., Regulation of opioid antiallodynic efficacy by cholecystokinin in a model of neuropathic pain in rats. J. Pharmacol. Exp. Ther., 275 (1995) 1339-1345.
13. Bantagonist in the rat, Neurosci. Lett., 181 (1995) 9-12.
14. [14] Payne, R., Neuropathic pain syndromes, with special reference to causalgia and reflex sympathetic dystrophy, Can. J. Pain, 2 (1986) 59-73.
15. [15] Roques, B.P., Fournie-Zaluski, M.C., Soroca, E., Lecomte, J.M., Malfroy, B., Llorens, C. and Schwartz, J.-C., The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice, Nature, 288 (1980) 286-288.
16. [16] Stanfa, L., Dickenson, A., Xu, X.-J. and Weisenfeld-Hallin, Z., Cholecystokinin and morphine analgesia, Trends Pharmacol. Sci., 15 (1994) 65-66.
17. [17] Stengaard-Pedersen, K. and Larsson, L.-I., Localization and opiate receptor binding of enkephalin, CCK and ACTH/b-endorphin in the rat central nervous system, Peptides, 2 (1981) 3-19.
18. [18] Stewart, P.E. and Hammond, D.L., Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat, J. Pharmacol. Exp. Ther., 268 (1994) 701-708.
19. [19] Suh, H.H. and Tseng, L.F., Differential effects of sulfated cholecystokinin octapeptide and proglumide injected intrathecally on antinociception induced by β-endorphin and morphine administered intracerebroventricularly in mice, Eur. J. Pharmacol., 179 (1990) 329-338.
20. [20] Tasker, R.R., Buda, T. and Hawryltshin, P., Clinical neurophysiological investigation of deaffenentation pain. In J.J. Bonica, U. Linblom and A. Iggo (Eds.), Advances in Pain Research and Therapy, Vol. 5, Raven Press/New Press, New York, 1983, pp. 713-738.
21. [21] Twycross, R.G., Morphine and diamorphine in the terminally ill patient, Acta Anesthesiol. Scand. (Suppl.), 74 (1982) 128-134.
22. B antagonist is mediated via opioid delta receptors, J. Pharmacol. Exp. Ther., 278 (1996) 212-219.
23. 5]enkephalin antiserum-sensitive enhancement of morphine antinociception, NeuroReport, 5 (1994) 2601-2605.
24. [24] Vanderah, T.W., Wild, K.D., Takemori, A.E., Sultana, M., Portoghese, P.S., Bowen, W.D., Mosberg, H.I. and Porreca, F., Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors, J. Pharmacol. Exp. Ther., 267 (1993) 449-455.
25. [25] Verge, V.M.K., Weisenfeld-Hallin, Z. and Hokfell, T., Cholecystokinin in mammalian primary sensory neurons and spinal cord: in situ hybridization studies in rat and monkey, Eur. J. Neurosci., 5 (1993) 240-250.
26. [26] Watkins, L.R., Kinchek, I.B., Kaufman, E.F.S., Miller, J., Frenk, H. and Mayer, D.J., Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates. Brain Res., 327 (1985) 181-190.
27. [27] Xu, X.-J., Puke, M.J.C., Verge, V.M.K., Weisenfeld-Hallin, Z.W., Hughes, J. and Hokfelt, T., Up-regulation of cholecystokinin in primary sensory neurons is associated with morphine insensitivity in experimental neuropathic pain in the rat, Neurosci. Lett., 152 (1993) 129-132.
28. [28] Yaksh, T.L., Pogrel, J.W., Lee, Y.W. and Chaplan, S.R., Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists, J. Pharmacol. Exp. Ther., 272 (1995) 207-214.
29. [29] Yaksh, T.L. and Rudy, T.A., Chronic catheterization of the spinal subarachnoid space, Physiol. Behav., 17 (1976) 1031-1036.